GSTDTAP

浏览/检索结果: 共7条,第1-7条 帮助

已选(0)清除 条数/页:   排序方式:
Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming 期刊论文
Global Change Biology, 2021
作者:  Chao Wang;  Yufeng Gong;  Fuchang Deng;  Enmin Ding;  Jie Tang;  Garry Codling;  Jonathan K. Challis;  Derek Green;  Jing Wang;  Qiliang Chen;  Yuwei Xie;  Shu Su;  Zilin Yang;  Jason Raine;  Paul D. Jones;  Song Tang;  John P. Giesy
收藏  |  浏览/下载:13/0  |  提交时间:2021/05/07
The association between maternal exposure to fine particulate matter (PM2.5) and gestational diabetes mellitus (GDM): a prospective birth cohort study in China 期刊论文
Environmental Research Letters, 2021
作者:  Guimin Chen;  Xiaoli Sun;  Jiaqi Wang;  Moran Dong;  Yufeng Ye;  Xin Liu;  Jiufeng Sun;  Jianpeng Xiao;  Guanhao He;  Jianxiong Hu;  Lingchuan Guo;  Xing Li;  Zuhua Rong;  Weilin Zeng;  He Zhou;  Dengzhou Chen;  Jiali Li;  Wenjun Ma;  Maksym Bartashevskyy;  Xiaozhong Wen;  Tao Liu
收藏  |  浏览/下载:12/0  |  提交时间:2021/04/20
Plastic pollution in croplands threatens long‐term food security 期刊论文
Global Change Biology, 2020
作者:  Dan Zhang;  Ee Ling Ng;  Wanli Hu;  Hongyuan Wang;  Pablo Galaviz;  Hude Yang;  Wentao Sun;  Chongxiao Li;  Xingwang Ma;  Bin Fu;  Peiyi Zhao;  Fulin Zhang;  Shuqin Jin;  Mingdong Zhou;  Lianfeng Du;  Chang Peng;  Xuejun Zhang;  Zhiyu Xu;  Bin Xi;  Xiaoxia Liu;  Shiyou Sun;  Zhenhua Cheng;  Lihua Jiang;  Yufeng Wang;  Liang Gong;  Changlin Kou;  Yan Li;  Youhua Ma;  Dongfeng Huang;  Jian Zhu;  Jianwu Yao;  Chaowen Lin;  Song Qin;  Liuqiang Zhou;  Binghui He;  Deli Chen;  Huanchun Li;  Limei Zhai;  Qiuliang Lei;  Shuxia Wu;  Yitao Zhang;  Junting Pan;  Baojing Gu;  Hongbin Liu
收藏  |  浏览/下载:13/0  |  提交时间:2020/05/13
Decoding the development of the human hippocampus 期刊论文
NATURE, 2020, 577 (7791) : 531-+
作者:  Zhong, Suijuan;  Ding, Wenyu;  Sun, Le;  Lu, Yufeng;  Dong, Hao;  Fan, Xiaoying;  Liu, Zeyuan;  Chen, Ruiguo;  Zhang, Shu;  Ma, Qiang;  Tang, Fuchou;  Wu, Qian;  Wang, Xiaoqun
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory(1,2). Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-seq) analysis to illustrate the cell types, cell linage, molecular features and transcriptional regulation of the developing human hippocampus. Using the transcriptomes of 30,416 cells from the human hippocampus at gestational weeks 16-27, we identify 47 cell subtypes and their developmental trajectories. We also identify the migrating paths and cell lineages of PAX6(+) and HOPX+ hippocampal progenitors, and regional markers of CA1, CA3 and dentate gyrus neurons. Multiomic data have uncovered transcriptional regulatory networks of the dentate gyrus marker PROX1. We also illustrate spatially specific gene expression in the developing human prefrontal cortex and hippocampus. The molecular features of the human hippocampus at gestational weeks 16-20 are similar to those of the mouse at postnatal days 0-5 and reveal gene expression differences between the two species. Transient expression of the primate-specific gene NBPF1 leads to a marked increase in PROX1(+) cells in the mouse hippocampus. These data provides a blueprint for understanding human hippocampal development and a tool for investigating related diseases.


Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.


  
The promise and challenge of therapeutic genome editing 期刊论文
NATURE, 2020, 578 (7794) : 229-236
作者:  Zhong, Suijuan;  Ding, Wenyu;  Sun, Le;  Lu, Yufeng;  Dong, Hao;  Fan, Xiaoying;  Liu, Zeyuan;  Chen, Ruiguo;  Zhang, Shu;  Ma, Qiang;  Tang, Fuchou;  Wu, Qian;  Wang, Xiaoqun
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Genome editing, which involves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits, has the potential to both improve our understanding of human genetics and cure genetic disease. Here I discuss the scientific, technical and ethical aspects of using CRISPR (clustered regularly interspaced short palindromic repeats) technology for therapeutic applications in humans, focusing on specific examples that highlight both opportunities and challenges. Genome editing is-or will soon be-in the clinic for several diseases, with more applications under development. The rapid pace of the field demands active efforts to ensure that this breakthrough technology is used responsibly to treat, cure and prevent genetic disease.


  
Effect of government subsidies on renewable energy investments: The threshold effect 期刊论文
ENERGY POLICY, 2019, 132: 156-166
作者:  Yang, Xiaolei;  He, Lingyun;  Xia, Yufei;  Chen, Yufeng
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Government subsidies  Renewable energy investment  Threshold effect  Bank credit  
Structural development and carbon dynamics of Moso bamboo forests in Zhejiang Province, China 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 409: 479-488
作者:  Xu, Lin;  Shi, Yongjun;  Zhou, Guomo;  Xu, Xiaojun;  Liu, Enbing;  Zhou, Yufeng;  Zhang, Feng;  Li, Chong;  Fang, Huiyun;  Chen, Liang
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Carbon dynamics  Structural development  Carbon sequestration  Aboveground carbon stock  Phyllostachys pubescent