The promise and challenge of therapeutic genome editing

doi:10.1038/s41586-020-1978-5

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-1978-5
	The promise and challenge of therapeutic genome editing
	Zhong, Suijuan 1,10; Ding, Wenyu 2,10; Sun, Le 1,3,4,10; Lu, Yufeng 1,4,10; Dong, Hao 1,4; Fan, Xiaoying 5; Liu, Zeyuan 1,4; Chen, Ruiguo 1,4; Zhang, Shu 5; Ma, Qiang 1,4; Tang, Fuchou 5,6,7; Wu, Qian 2,8; Wang, Xiaoqun 1,3,4,9
	2020
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	578 期号:7794 页码:229-236
文章类型	Review
语种	英语
国家	USA
英文关键词	Genome editing, which involves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits, has the potential to both improve our understanding of human genetics and cure genetic disease. Here I discuss the scientific, technical and ethical aspects of using CRISPR (clustered regularly interspaced short palindromic repeats) technology for therapeutic applications in humans, focusing on specific examples that highlight both opportunities and challenges. Genome editing is-or will soon be-in the clinic for several diseases, with more applications under development. The rapid pace of the field demands active efforts to ensure that this breakthrough technology is used responsibly to treat, cure and prevent genetic disease.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000513110500019
WOS关键词	CAS9 RIBONUCLEOPROTEIN ; HEMATOPOIETIC STEM ; GENE MUTATION ; DELIVERY ; CRISPR ; DNA ; RNA ; PLATFORM ; NANOPARTICLES ; REPAIR
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281337
专题	地球科学资源环境科学气候变化
作者单位	1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Biophys,Inst Brain Intelligence Technol Shan, Beijing, Peoples R China; 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China; 3.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.Peking Univ, Coll Life Sci, Beijing Adv Innovat Ctr Genom, Beijing, Peoples R China; 6.Biomed Inst Pioneering Investigat Via Convergence, Beijing, Peoples R China; 7.Ctr Reprod Med, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing, Peoples R China; 8.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China; 9.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China; 10.Beijing Inst Brain Disorders, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Suijuan,Ding, Wenyu,Sun, Le,et al. The promise and challenge of therapeutic genome editing[J]. NATURE,2020,578(7794):229-236.
APA	Zhong, Suijuan.,Ding, Wenyu.,Sun, Le.,Lu, Yufeng.,Dong, Hao.,...&Wang, Xiaoqun.(2020).The promise and challenge of therapeutic genome editing.NATURE,578(7794),229-236.
MLA	Zhong, Suijuan,et al."The promise and challenge of therapeutic genome editing".NATURE 578.7794(2020):229-236.