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Where I work Maria Josefa Verdugo 期刊论文
NATURE, 2020, 580 (7801) : 158-158
作者:  Farquharson, Jamie I.;  Amelung, Falk
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03

Maria Josefa Verdugo ships into the bitter cold of far-northern waters to measure ice-core properties as part of a year-round climate project.


Maria Josefa Verdugo ships into the bitter cold of far-northern waters to measure ice-core properties as part of a year-round climate project.


  
Nuclear force probed at short distances 期刊论文
NATURE, 2020, 578 (7796) : 524-525
作者:  Shukla, Aditi;  Yen, Jenny;  Pagano, Daniel J.;  Dodso, Anne E.;  Fei, Yuhan;  Gorham, Josh;  Seidman, J. G.;  Wickens, Marvin;  Kennedy, Scott
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

The dense soup of matter in the core of neutron stars is hard to model, but particle-accelerator experiments in which energetic electrons scatter off atomic nuclei could help to explore this high-density regime.


A test of effective nucleon-nucleon interactions at short separations.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity 期刊论文
NATURE, 2020, 577 (7792) : 682-+
作者:  Nahas, Y.;  Prokhorenko, S.;  Fischer, J.;  Xu, B.;  Carretero, C.;  Prosandeev, S.;  Bibes, M.;  Fusil, S.;  Dkhil, B.;  Garcia, V.;  Bellaiche, L.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis suppresses the production of inflammatory cytokines by host cells through the host-mediated ubiquitination of a mycobacterial protein, enhancing the interaction of a host signalling inhibitor with another signalling molecule.


Mycobacterium tuberculosis is an intracellular pathogen that uses several strategies to interfere with the signalling functions of host immune molecules. Many other bacterial pathogens exploit the host ubiquitination system to promote pathogenesis(1,2), but whether this same system modulates the ubiquitination of M. tuberculosis proteins is unknown. Here we report that the host E3 ubiquitin ligase ANAPC2-a core subunit of the anaphase-promoting complex/cyclosome-interacts with the mycobacterial protein Rv0222 and promotes the attachment of lysine-11-linked ubiquitin chains to lysine 76 of Rv0222 in order to suppress the expression of proinflammatory cytokines. Inhibition of ANAPC2 by specific short hairpin RNA abolishes the inhibitory effect of Rv0222 on proinflammatory responses. Moreover, mutation of the ubiquitination site on Rv0222 impairs the inhibition of proinflammatory cytokines by Rv0222 and reduces virulence during infection in mice. Mechanistically, lysine-11-linked ubiquitination of Rv0222 by ANAPC2 facilitates the recruitment of the protein tyrosine phosphatase SHP1 to the adaptor protein TRAF6, preventing the lysine-63-linked ubiquitination and activation of TRAF6. Our findings identify a previously unrecognized mechanism that M. tuberculosis uses to suppress host immunity, and provide insights relevant to the development of effective immunomodulators that target M. tuberculosis.


  
Pervasive Arctic lead pollution suggests substantial growth in medieval silver production modulated by plague, climate, and conflict 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (30) : 14910-14915
作者:  McConnell, Joseph R.;  Chellman, Nathan J.;  Wilson, Andrew I.;  Stohl, Andreas;  Arienzo, Monica M.;  Eckhardt, Sabine;  Fritzsche, Diedrich;  Kipfstuhl, Sepp;  Opel, Thomas;  Place, Philip F.;  Steffensen, Jorgen Peder
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
ice core  lead pollution  Arctic  plague  Middle Ages