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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody 期刊论文
Science, 2021
作者:  C. Garrett Rappazzo;  Longping V. Tse;  Chengzi I. Kaku;  Daniel Wrapp;  Mrunal Sakharkar;  Deli Huang;  Laura M. Deveau;  Thomas J. Yockachonis;  Andrew S. Herbert;  Michael B. Battles;  Cecilia M. O’Brien;  Michael E. Brown;  James C. Geoghegan;  Jonathan Belk;  Linghang Peng;  Linlin Yang;  Yixuan Hou;  Trevor D. Scobey;  Dennis R. Burton;  David Nemazee;  John M. Dye;  James E. Voss;  Bronwyn M. Gunn;  Jason S. McLellan;  Ralph S. Baric;  Lisa E. Gralinski;  Laura M. Walker
收藏  |  浏览/下载:22/0  |  提交时间:2021/02/22
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载:19/0  |  提交时间:2020/12/22
Broad neutralization of SARS-related viruses by human monoclonal antibodies 期刊论文
Science, 2020
作者:  Anna Z. Wec;  Daniel Wrapp;  Andrew S. Herbert;  Daniel P. Maurer;  Denise Haslwanter;  Mrunal Sakharkar;  Rohit K. Jangra;  M. Eugenia Dieterle;  Asparouh Lilov;  Deli Huang;  Longping V. Tse;  Nicole V. Johnson;  Ching-Lin Hsieh;  Nianshuang Wang;  Juergen H. Nett;  Elizabeth Champney;  Irina Burnina;  Michael Brown;  Shu Lin;  Melanie Sinclair;  Carl Johnson;  Sarat Pudi;  Robert Bortz;  Ariel S. Wirchnianski;  Ethan Laudermilch;  Catalina Florez;  J. Maximilian Fels;  Cecilia M. O’Brien;  Barney S. Graham;  David Nemazee;  Dennis R. Burton;  Ralph S. Baric;  James E. Voss;  Kartik Chandran;  John M. Dye;  Jason S. McLellan;  Laura M. Walker
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
WHY HEALTHY ARTERIES MIGHT HELP KIDS AVOID COVID COMPLICATIONS 期刊论文
NATURE, 2020, 582 (7812) : 324-325
作者:  Niu, Jixiao;  Sun, Yang;  Chen, Baoen;  Zheng, Baohui;  Jarugumilli, Gopala K.;  Walker, Sarah R.;  Hata, Aaron N.;  Mino-Kenudson, Mari;  Frank, David A.;  Wu, Xu
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03
Validation of SAGE III/ISS Solar Occultation Ozone Products With Correlative Satellite and Ground-Based Measurements 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (11)
作者:  Wang, H. J. Ray;  Damadeo, Robert;  Flittner, David;  Kramarova, Natalya;  Taha, Ghassan;  Davis, Sean;  Thompson, Anne M.;  Strahan, Susan;  Wang, Yuhang;  Froidevaux, Lucien;  Degenstein, Doug;  Bourassa, Adam;  Steinbrecht, Wolfgang;  Walker, Kaley A.;  Querel, Richard;  Leblanc, Thierry;  Godin-Beekmann, Sophie;  Hurst, Dale;  Hall, Emrys
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/18
Transparent ferroelectric crystals with ultrahigh piezoelectricity 期刊论文
NATURE, 2020, 577 (7790) : 350-+
作者:  Qiu, Chaorui;  Wang, Bo;  Zhang, Nan;  Zhang, Shujun;  Liu, Jinfeng;  Walker, David;  Wang, Yu;  Tian, Hao;  Shrout, Thomas R.;  Xu, Zhuo;  Chen, Long-Qing;  Li, Fei
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Transparent piezoelectrics are highly desirable for numerous hybrid ultrasound-optical devices ranging from photoacoustic imaging transducers to transparent actuators for haptic applications(1-7). However, it is challenging to achieve high piezoelectricity and perfect transparency simultaneously because most high-performance piezoelectrics are ferroelectrics that contain high-density light-scattering domain walls. Here, through a combination of phase-field simulations and experiments, we demonstrate a relatively simple method of using an alternating-current electric field to engineer the domain structures of originally opaque rhombohedral Pb(Mg1/3Nb2/3)O-3-PbTiO3 (PMN-PT) crystals to simultaneously generate near-perfect transparency, an ultrahigh piezoelectric coefficient d(33) (greater than 2,100 picocoulombs per newton), an excellent electromechanical coupling factor k(33) (about 94 per cent) and a large electro-optical coefficient gamma(33) (approximately 220 picometres per volt), which is far beyond the performance of the commonly used transparent ferroelectric crystal LiNbO3. We find that increasing the domain size leads to a higher d(33) value for the [001]-oriented rhombohedral PMN-PT crystals, challenging the conventional wisdom that decreasing the domain size always results in higher piezoelectricity(8-10). This work presents a paradigm for achieving high transparency and piezoelectricity by ferroelectric domain engineering, and we expect the transparent ferroelectric crystals reported here to provide a route to a wide range of hybrid device applications, such as medical imaging, self-energy-harvesting touch screens and invisible robotic devices.


  
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis 期刊论文
NATURE, 2020, 578 (7793) : 166-+
作者:  Qiu, Chaorui;  Wang, Bo;  Zhang, Nan;  Zhang, Shujun;  Liu, Jinfeng;  Walker, David;  Wang, Yu;  Tian, Hao;  Shrout, Thomas R.;  Xu, Zhuo;  Chen, Long-Qing;  Li, Fei
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03

Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment(1,2). Recent studies have shown that increases in neuronal activity have an important role in the proliferation and progression of glioblastoma(3,4). Whether there is reciprocal crosstalk between glioblastoma and neurons remains poorly defined, as the mechanisms that underlie how these tumours remodel the neuronal milieu towards increased activity are unknown. Here, using a native mouse model of glioblastoma, we develop a high-throughput in vivo screening platform and discover several driver variants of PIK3CA. We show that tumours driven by these variants have divergent molecular properties that manifest in selective initiation of brain hyperexcitability and remodelling of the synaptic constituency. Furthermore, secreted members of the glypican (GPC) family are selectively expressed in these tumours, and GPC3 drives gliomagenesis and hyperexcitability. Together, our studies illustrate the importance of functionally interrogating diverse tumour phenotypes driven by individual, yet related, variants and reveal how glioblastoma alters the neuronal microenvironment.


Glioblastoma tumours expressing oncogenic PIK3CA variants secrete the glycan GPC3, which promotes the formation of neural synapses, brain synaptic hyperexcitability and gliomagenesis.


  
Rapid, large-volume, thermally controlled 3D printing using a mobile liquid interface 期刊论文
SCIENCE, 2019, 366 (6463) : 360-+
作者:  Walker, David A.;  Hedrick, James L.;  Mirkin, Chad A.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Amazon forest response to CO2 fertilization dependent on plant phosphorus acquisition 期刊论文
NATURE GEOSCIENCE, 2019, 12 (9) : 736-+
作者:  Fleischer, Katrin;  Rammig, Anja;  De Kauwe, Martin G.;  Walker, Anthony P.;  Domingues, Tomas F.;  Fuchslueger, Lucia;  Garcia, Sabrina;  Goll, Daniel S.;  Grandis, Adriana;  Jiang, Mingkai;  Haverd, Vanessa;  Hofhansl, Florian;  Holm, Jennifer A.;  Kruijt, Bart;  Leung, Felix;  Medlyn, Belinda E.;  Mercado, Lina M.;  Norby, Richard J.;  Pak, Bernard;  von Randow, Celso;  Quesada, Carlos A.;  Schaap, Karst J.;  Valverde-Barrantes, Oscar J.;  Wang, Ying-Ping;  Yang, Xiaojuan;  Zaehle, Sonke;  Zhu, Qing;  Lapola, David M.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27