GSTDTAP

浏览/检索结果: 共30条,第1-10条 帮助

限定条件                
已选(0)清除 条数/页:   排序方式:
Ionospheric topside diffusive flux and the formation of summer nighttime ionospheric electron density enhancement over Millstone Hill 期刊论文
Geophysical Research Letters, 2022
作者:  Yihui Cai;  Xinan Yue;  Wenbin Wang;  Shun-Rong Zhang;  Huixin Liu;  Jiuhou Lei;  Zhipeng Ren;  Yiding Chen;  Feng Ding;  Dexin Ren
收藏  |  浏览/下载:16/0  |  提交时间:2022/02/23
Two types of the East Asian Cold Surge and Their Impacts on El Niño 期刊论文
Geophysical Research Letters, 2022
作者:  Jie Feng;  Tao Lian;  Yihui Ding;  Xichen Li;  Cheng Sun;  Dake Chen
收藏  |  浏览/下载:13/0  |  提交时间:2022/02/16
Impact of Anthropogenic Emission Changes on the Occurrence of Equatorial Plasma Bubbles 期刊论文
Geophysical Research Letters, 2022
作者:  Xu Zhou;  Xinan Yue;  Zhipeng Ren;  Yunbo Liu;  Yihui Cai;  Feng Ding;  Yong Wei
收藏  |  浏览/下载:13/0  |  提交时间:2022/02/16
Wintertime submesoscale offshore events overcoming wind-driven onshore currents in the East China Sea 期刊论文
Geophysical Research Letters, 2021
作者:  Jiliang Xuan;  Ruibin Ding;  Xiaobo Ni;  Daji Huang;  Jianfang Chen;  Feng Zhou
收藏  |  浏览/下载:16/0  |  提交时间:2021/11/23
Increasing difference in interannual summertime surface air temperature between interior East Antarctica and the Antarctic Peninsula under future climate scenarios 期刊论文
Geophysical Research Letters, 2021
作者:  Rui Mao;  Seong-Joong Kim;  Dao-Yi Gong;  Xiaohong Liu;  Xinyu Wen;  Liping Zhang;  Feng Tang;  Qi Zong;  Cunde Xiao;  Minghu Ding;  Sang-Jong Park
收藏  |  浏览/下载:15/0  |  提交时间:2021/08/10
NOx Emission Changes over China during the COVID‐19 Epidemic Inferred from Surface NO2 Observations 期刊论文
Geophysical Research Letters, 2020
作者:  Shuzhuang Feng;  Fei Jiang;  Hengmao Wang;  Haikun Wang;  Weimin Ju;  Yang Shen;  Yanhua Zheng;  Zheng Wu;  Aijun Ding
收藏  |  浏览/下载:7/0  |  提交时间:2020/09/30
Reservoir construction has reduced organic carbon deposition in the East China Sea by half since 2006 期刊论文
Geophysical Research Letters, 2020
作者:  Chenglong Wang;  Zhe Hao;  Jianhua Gao;  Ziyue Feng;  Yongcheng Ding;  Chuchu Zhang;  Xinqing Zou
收藏  |  浏览/下载:8/0  |  提交时间:2020/08/25
Ancient DNA indicates human population shifts and admixture in northern and southern China 期刊论文
Science, 2020
作者:  Melinda A. Yang;  Xuechun Fan;  Bo Sun;  Chungyu Chen;  Jianfeng Lang;  Ying-Chin Ko;  Cheng-hwa Tsang;  Hunglin Chiu;  Tianyi Wang;  Qingchuan Bao;  Xiaohong Wu;  Mateja Hajdinjak;  Albert Min-Shan Ko;  Manyu Ding;  Peng Cao;  Ruowei Yang;  Feng Liu;  Birgit Nickel;  Qingyan Dai;  Xiaotian Feng;  Lizhao Zhang;  Chengkai Sun;  Chao Ning;  Wen Zeng;  Yongsheng Zhao;  Ming Zhang;  Xing Gao;  Yinqiu Cui;  David Reich;  Mark Stoneking;  Qiaomei Fu
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/21
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
Science, 2020
作者:  Zhiwei Zhou;  Huabin He;  Kun Wang;  Xuyan Shi;  Yupeng Wang;  Ya Su;  Yao Wang;  Da Li;  Wang Liu;  Yongliang Zhang;  Lianjun Shen;  Weidong Han;  Lin Shen;  Jingjin Ding;  Feng Shao
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/01
Integrating genomic features for non-invasive early lung cancer detection 期刊论文
NATURE, 2020, 580 (7802) : 245-+
作者:  Wang, Qinyang;  Wang, Yupeng;  Ding, Jingjin;  Wang, Chunhong;  Zhou, Xuehan;  Gao, Wenqing;  Huang, Huanwei;  Shao, Feng;  Liu, Zhibo
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Circulating tumour DNA in blood is analysed to identify genomic features that distinguish early-stage lung cancer patients from risk-matched controls, and these are integrated into a machine-learning method for blood-based lung cancer screening.


Radiologic screening of high-risk adults reduces lung-cancer-related mortality(1,2)  however, a small minority of eligible individuals undergo such screening in the United States(3,4). The availability of blood-based tests could increase screening uptake. Here we introduce improvements to cancer personalized profiling by deep sequencing (CAPP-Seq)(5), a method for the analysis of circulating tumour DNA (ctDNA), to better facilitate screening applications. We show that, although levels are very low in early-stage lung cancers, ctDNA is present prior to treatment in most patients and its presence is strongly prognostic. We also find that the majority of somatic mutations in the cell-free DNA (cfDNA) of patients with lung cancer and of risk-matched controls reflect clonal haematopoiesis and are non-recurrent. Compared with tumour-derived mutations, clonal haematopoiesis mutations occur on longer cfDNA fragments and lack mutational signatures that are associated with tobacco smoking. Integrating these findings with other molecular features, we develop and prospectively validate a machine-learning method termed '  lung cancer likelihood in plasma'  (Lung-CLiP), which can robustly discriminate early-stage lung cancer patients from risk-matched controls. This approach achieves performance similar to that of tumour-informed ctDNA detection and enables tuning of assay specificity in order to facilitate distinct clinical applications. Our findings establish the potential of cfDNA for lung cancer screening and highlight the importance of risk-matching cases and controls in cfDNA-based screening studies.