中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共15条，第1-10条 帮助

限定条件                
已选(0)清除 条数/页：   排序方式：
The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia 期刊论文
Science, 2021
作者:  Zengzhang Zheng;  Wanyan Deng;  Yang Bai;  Rui Miao;  Shenglin Mei;  Zhibin Zhang;  Youdong Pan;  Yi Wang;  Rui Min;  Fan Deng;  Zeyu Wu;  Wu Li;  Pengcheng Chen;  Tianchi Ma;  Xiwen Lou;  Judy Lieberman;  Xing Liu
收藏  |  浏览/下载：11/0  |  提交时间：2021/07/27
Reversing extinction in China's Père David's deer 期刊论文
Science, 2021
作者:  Yuanyuan Zhang;  Jiade Bai;  Annah Zhu;  Ruishan Chen;  Dayuan Xue;  Zhenyu Zhong;  Zhibin Cheng
收藏  |  浏览/下载：10/0  |  提交时间：2021/02/17
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Interspecific synchrony of seed rain shapes rodent-mediated indirect seed-seed interactions of sympatric tree species in a subtropical forest 期刊论文
ECOLOGY LETTERS, 2019
作者:  Yang, Xifu;  Yan, Chuan;  Gu, Haifeng;  Zhang, Zhibin
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Apparent competition  apparent mutualism  apparent predation  masting  rodents  scatter-hoarding  seed dispersal effectiveness  seed rain  seed traits  
Biochar application as a tool to decrease soil nitrogen losses (NH3 volatilization, N2O emissions, and N leaching) from croplands: Options and mitigation strength in a global perspective 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (6) : 2077-2093
作者:  Liu, Qi;  Liu, Benjuan;  Zhang, Yanhui;  Hu, Tianlong;  Lin, Zhibin;  Liu, Gang;  Wang, Xiaojie;  Ma, Jing;  Wang, Hui;  Jin, Haiyang;  Ambus, Per;  Amonette, James E.;  Xie, Zubin
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
biochar  machine learning  N leaching  N2O  NH3  spatial variability  
Historical and genomic data reveal the influencing factors on global transmission velocity of plague during the Third Pandemic 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (24) : 11833-11838
作者:  Xu, Lei;  Stige, Leif C.;  Leirs, Herwig;  Neerinckx, Simon;  Gage, Kenneth L.;  Yang, Ruifu;  Liu, Qiyong;  Bramanti, Barbara;  Dean, Katharine R.;  Tang, Hui;  Sun, Zhe;  Stenseth, Nils Chr.;  Zhang, Zhibin
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
Yersinia pestis  Third Pandemic  climate change  global transmission velocity  historical and genomic data  
An autoimmune disease variant of IgG1 modulates B cell activation and differentiation 期刊论文
SCIENCE, 2018, 362 (6415) : 700-+
作者:  Chen, Xiangjun;  Sun, Xiaolin;  Yang, Wei;  Yang, Bing;  Zhao, Xiaozhen;  Chen, Shuting;  He, Lili;  Chen, Hui;  Yang, Changmei;  Xiao, Le;  Chang, Zai;  Guo, Jianping;  He, Jing;  Zhang, Fuping;  Zheng, Fang;  Hu, Zhibin;  Yang, Zhiyong;  Lou, Jizhong;  Zheng, Wenjie;  Qi, Hai;  Xu, Chenqi;  Zhang, Hong;  Shan, Hongying;  Zhou, Xu-jie;  Wang, Qingwen;  Shi, Yi;  Lai, Luhua;  Li, Zhanguo;  Liu, Wanli
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems 期刊论文
SCIENCE, 2017, 355 (6325)
作者:  Barnosky, Anthony D.;  Hadly, Elizabeth A.;  Gonzalez, Patrick;  Head, Jason;  Polly, P. David;  Lawing, A. Michelle;  Eronen, Jussi T.;  Ackerly, David D.;  Alex, Ken;  Biber, Eric;  Blois, Jessica;  Brashares, Justin;  Ceballos, Gerardo;  Davis, Edward;  Dietl, Gregory P.;  Dirzo, Rodolfo;  Doremus, Holly;  Fortelius, Mikael;  Greene, Harry W.;  Hellmann, Jessica;  Hickler, Thomas;  Jackson, Stephen T.;  Kemp, Melissa;  Koch, Paul L.;  Kremen, Claire;  Lindsey, Emily L.;  Looy, Cindy;  Marshall, Charles R.;  Mendenhall, Chase;  Mulch, Andreas;  Mychajliw, Alexis M.;  Nowak, Carsten;  Ramakrishnan, Uma;  Schnitzler, Jan;  Das Shrestha, Kashish;  Solari, Katherine;  Stegner, Lynn;  Stegner, M. Allison;  Stenseth, Nils Chr;  Wake, Marvalee H.;  Zhang, Zhibin
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems 期刊论文
Science, 2017, 355 (6325) : ) as they drag bone-laden carnivore scat and raptor pellets into their middens are particularly useful in sampling the vertebrate and plant community with high fidelity to taxonomic composition and relative abundance (46–48)
作者:  Anthony D. Barnosky;  Elizabeth A. Hadly;  Patrick Gonzalez;  Jason Head;  P. David Polly;  A. Michelle Lawing;  Jussi T. Eronen;  David D. Ackerly;  Ken Alex;  Eric Biber;  Jessica Blois;  Justin Brashares;  Gerardo Ceballos;  Edward Davis;  Gregory P. Dietl;  Rodolfo Dirzo;  Holly Doremus;  Mikael Fortelius;  Harry W. Greene;  Jessica Hellmann;  Thomas Hickler;  Stephen T. Jackson;  Melissa Kemp;  Paul L. Koch;  Claire Kremen;  Emily L. Lindsey;  Cindy Looy;  Charles R. Marshall;  Chase Mendenhall;  Andreas Mulch;  Alexis M. Mychajliw;  Carsten Nowak;  Uma Ramakrishnan;  Jan Schnitzler;  Kashish Das Shrestha;  Katherine Solari;  Lynn Stegner;  M. Allison Stegner;  Nils Chr. Stenseth;  Marvalee H. Wake;  Zhibin Zhang
收藏  |  浏览/下载：13/0  |  提交时间：2020/04/17
Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems 期刊论文
Science, 2017, 355 (6325) : ) as they drag bone-laden carnivore scat and raptor pellets into their middens are particularly useful in sampling the vertebrate and plant community with high fidelity to taxonomic composition and relative abundance (46–48)
作者:  Anthony D. Barnosky;  Elizabeth A. Hadly;  Patrick Gonzalez;  Jason Head;  P. David Polly;  A. Michelle Lawing;  Jussi T. Eronen;  David D. Ackerly;  Ken Alex;  Eric Biber;  Jessica Blois;  Justin Brashares;  Gerardo Ceballos;  Edward Davis;  Gregory P. Dietl;  Rodolfo Dirzo;  Holly Doremus;  Mikael Fortelius;  Harry W. Greene;  Jessica Hellmann;  Thomas Hickler;  Stephen T. Jackson;  Melissa Kemp;  Paul L. Koch;  Claire Kremen;  Emily L. Lindsey;  Cindy Looy;  Charles R. Marshall;  Chase Mendenhall;  Andreas Mulch;  Alexis M. Mychajliw;  Carsten Nowak;  Uma Ramakrishnan;  Jan Schnitzler;  Kashish Das Shrestha;  Katherine Solari;  Lynn Stegner;  M. Allison Stegner;  Nils Chr. Stenseth;  Marvalee H. Wake;  Zhibin Zhang
收藏  |  浏览/下载：24/0  |  提交时间：2020/04/17