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Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载：143/0  |  提交时间：2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Facilitation promotes invasions in plant-associated microbial communities 期刊论文
ECOLOGY LETTERS, 2019, 22 (1) : 149-158
作者:  Li, Mei;  Wei, Zhong;  Wang, Jianing;  Jousset, Alexandre;  Friman, Ville-Petri;  Xu, Yangchun;  Shen, Qirong;  Pommier, Thomas
收藏  |  浏览/下载：18/0  |  提交时间：2019/04/09
Antagonism  community ecology  facilitation  invasion resistance  microbe-microbe-plant interactions  rhizosphere  
Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II 期刊论文
SCIENCE, 2018, 360 (6393) : 1109-1112
作者:  Pan, Xiaowei;  Ma, Jun;  Su, Xiaodong;  Cao, Peng;  Chang, Wenrui;  Liu, Zhenfeng;  Zhang, Xinzheng;  Li, Mei
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex 期刊论文
SCIENCE, 2017, 357 (6353) : 816-+
作者:  Su, Xiaodong;  Ma, Jun;  Wei, Xuepeng;  Cao, Peng;  Zhu, Dongjie;  Chang, Wenrui;  Liu, Zhenfeng;  Zhang, Xinzheng;  Li, Mei
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27