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Contrasting effects of emission control on air pollution in Central China during the 2019 Military World Games based on satellite and ground observations 期刊论文
Atmospheric Research, 2021
作者:  Minghui Tao, Haijun Huang, Nan Chen, Fengfei Ma, ... Lu Gui
收藏  |  浏览/下载:6/0  |  提交时间:2021/05/07
Estimation of Urban Ecosystem Services Value: A Case Study of Chengdu, Southwestern China 科技报告
来源:Institute for Global Environmental Strategies. 出版年: 2021
作者:  Xiaoai, Dai;  Johnson, Brian;  Luo, Penglan;  Yang, Kai;  Dong, Linxin;  Wang, Qiang;  Liu, Chao;  Li, Naiwen;  Lu, Heng;  Ma, Lei;  Yang, Zhengli;  Yao, Yuanzhi
收藏  |  浏览/下载:14/0  |  提交时间:2021/01/22
Global modeling of heterogeneous hydroxymethanesulfonate chemistry 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Shaojie Song, Tao Ma, Yuzhong Zhang, Lu Shen, Pengfei Liu, Ke Li, Shixian Zhai, Haotian Zheng, Meng Gao, Fengkui Duan, Kebin He, and Michael B. McElroy
收藏  |  浏览/下载:20/0  |  提交时间:2020/08/09
Spatially coherent clusters of summer precipitation extremes in the Tibetan Plateau: Where is the moisture from? 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Ma, Yingzhao;  Lu, Mengqian;  Bracken, Cameron;  Chen, Haonan
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
Model bias in simulating major chemical components of PM2.5 in China 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ruqian Miao, Qi Chen, Yan Zheng, Xi Cheng, Yele Sun, Paul I. Palmer, Manish Shrivastava, Jianping Guo, Qiang Zhang, Yuhan Liu, Zhaofeng Tan, Xuefei Ma, Shiyi Chen, Limin Zeng, Keding Lu, and Yuanhang Zhang
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Decoding the development of the human hippocampus 期刊论文
NATURE, 2020, 577 (7791) : 531-+
作者:  Zhong, Suijuan;  Ding, Wenyu;  Sun, Le;  Lu, Yufeng;  Dong, Hao;  Fan, Xiaoying;  Liu, Zeyuan;  Chen, Ruiguo;  Zhang, Shu;  Ma, Qiang;  Tang, Fuchou;  Wu, Qian;  Wang, Xiaoqun
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory(1,2). Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-seq) analysis to illustrate the cell types, cell linage, molecular features and transcriptional regulation of the developing human hippocampus. Using the transcriptomes of 30,416 cells from the human hippocampus at gestational weeks 16-27, we identify 47 cell subtypes and their developmental trajectories. We also identify the migrating paths and cell lineages of PAX6(+) and HOPX+ hippocampal progenitors, and regional markers of CA1, CA3 and dentate gyrus neurons. Multiomic data have uncovered transcriptional regulatory networks of the dentate gyrus marker PROX1. We also illustrate spatially specific gene expression in the developing human prefrontal cortex and hippocampus. The molecular features of the human hippocampus at gestational weeks 16-20 are similar to those of the mouse at postnatal days 0-5 and reveal gene expression differences between the two species. Transient expression of the primate-specific gene NBPF1 leads to a marked increase in PROX1(+) cells in the mouse hippocampus. These data provides a blueprint for understanding human hippocampal development and a tool for investigating related diseases.


Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.


  
The promise and challenge of therapeutic genome editing 期刊论文
NATURE, 2020, 578 (7794) : 229-236
作者:  Zhong, Suijuan;  Ding, Wenyu;  Sun, Le;  Lu, Yufeng;  Dong, Hao;  Fan, Xiaoying;  Liu, Zeyuan;  Chen, Ruiguo;  Zhang, Shu;  Ma, Qiang;  Tang, Fuchou;  Wu, Qian;  Wang, Xiaoqun
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Genome editing, which involves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits, has the potential to both improve our understanding of human genetics and cure genetic disease. Here I discuss the scientific, technical and ethical aspects of using CRISPR (clustered regularly interspaced short palindromic repeats) technology for therapeutic applications in humans, focusing on specific examples that highlight both opportunities and challenges. Genome editing is-or will soon be-in the clinic for several diseases, with more applications under development. The rapid pace of the field demands active efforts to ensure that this breakthrough technology is used responsibly to treat, cure and prevent genetic disease.


  
Combining disdrometer, microscopic photography, and cloud radar to study distributions of hydrometeor types, size and fall velocity 期刊论文
ATMOSPHERIC RESEARCH, 2019, 228: 176-185
作者:  Jia, Xingcan;  Liu, Yangang;  Ding, Deping;  Ma, Xincheng;  Chen, Yichen;  Bi, Kai;  Tian, Ping;  Lu, Chunsong;  Quan, Jiannong
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Hydrometeor fall velocity  Hydrometeor size distribution  PARSIVEL disdrometer  Microscope photography  Cloud radar  
Phase-change heterostructure enables ultralow noise and drift for memory operation 期刊论文
SCIENCE, 2019, 366 (6462) : 210-+
作者:  Ding, Keyuan;  Wang, Jiangjing;  Zhou, Yuxing;  Tian, He;  Lu, Lu;  Mazzarello, Riccardo;  Jia, Chunlin;  Zhang, Wei;  Rao, Feng;  Ma, Evan
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27