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Conserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies 期刊论文
Nature Communications, 2021
作者:  Chazot, Nicolas;  Condamine, Fabien L.;  Dudas, Gytis;  Peñ;  a, Carlos;  Kodandaramaiah, Ullasa;  Matos-Maraví;  , Pá;  vel;  Aduse-Poku, Kwaku;  Elias, Marianne;  Warren, Andrew D.;  Lohman, David J.;  Penz, Carla M.;  DeVries, Phil;  Fric, Zdenek F.;  Nylin, Soren;  Mü;  ller, Chris;  Kawahara, Akito Y.;  Silva-Brandã;  o, Karina L.;  Lamas, Gerardo;  Kleckova, Irena;  Zubek, Anna;  Ortiz-Acevedo, Elena;  Vila, Roger;  Vane-Wright, Richard I.;  Mullen, Sean P.;  Jiggins, Chris D.;  Wheat, Christopher W.;  Freitas, Andre V. L.;  Wahlberg, Niklas
收藏  |  浏览/下载：10/0  |  提交时间：2021/10/07
Seasonal Arctic sea ice forecasting with probabilistic deep learning 期刊论文
Nature Communications, 2021
作者:  Andersson, Tom R.;  Hosking, J. Scott;  Pé;  rez-Ortiz, Marí;  a;  Paige, Brooks;  Elliott, Andrew;  Russell, Chris;  Law, Stephen;  Jones, Daniel C.;  Wilkinson, Jeremy;  Phillips, Tony;  Byrne, James;  Tietsche, Steffen;  Sarojini, Beena Balan;  Blanchard-Wrigglesworth, Eduardo;  Aksenov, Yevgeny;  Downie, Rod;  Shuckburgh, Emily
收藏  |  浏览/下载：12/0  |  提交时间：2021/08/30
Continental-Scale Geographic Trends in Barometric-Pumping Efficiency Potential: A North American Case Study 期刊论文
Geophysical Research Letters, 2021
作者:  Sofia T. Avendañ;  o;  Dylan Harp;  Sudarshan Kurwadkar;  John P. Ortiz;  Philip H. Stauffer
收藏  |  浏览/下载：13/0  |  提交时间：2021/08/17
Long-term increases in pathogen seroprevalence in polar bears (Ursus maritimus) influenced by climate change 期刊论文
Global Change Biology, 2021
作者:  Nicholas W. Pilfold;  Evan S. Richardson;  John Ellis;  Emily Jenkins;  W. Brad Scandrett;  Adriá;  n Herná;  ndez-Ortiz;  Kayla Buhler;  David McGeachy;  Batol Al-Adhami;  Kelly Konecsni;  Vladislav A. Lobanov;  Megan A. Owen;  Bruce Rideout;  Nicholas J. Lunn
收藏  |  浏览/下载：18/0  |  提交时间：2021/07/27
Host genetics influence the gut microbiome 期刊论文
Science, 2021
作者:  Liliana Cortes-Ortiz;  Katherine R. Amato
收藏  |  浏览/下载：6/0  |  提交时间：2021/07/27
Seagrass (Halophila stipulacea) invasion enhances carbon sequestration in the Mediterranean Sea 期刊论文
Global Change Biology, 2021
作者:  Marlene Wesselmann;  Nathan R. Geraldi;  Carlos M. Duarte;  Jordi Garcia‐;  Orellana;  Rubé;  n Dí;  az‐;  Rú;  a;  Ariane Arias‐;  Ortiz;  Iris E. Hendriks;  Eugenia T. Apostolaki;  Nú;  ria Marbà
收藏  |  浏览/下载：16/0  |  提交时间：2021/04/20
Tracking subsurface active weathering processes in serpentinite 期刊论文
Geophysical Research Letters, 2021
作者:  Masako Tominaga;  Estefania Ortiz;  Joshua Franz Einsle;  Noah Francis Ryoichi Vento;  Matthew O Schrenk;  Iris Buisman;  Isra S. Ezad;  Dawn Cardace
收藏  |  浏览/下载：5/0  |  提交时间：2021/01/28
Seagrass losses since mid‐20th century fuelled CO2 emissions from soil carbon stocks 期刊论文
Global Change Biology, 2020
作者:  Cristian Salinas;  Carlos M. Duarte;  Paul S. Lavery;  Pere Masque;  Ariane Arias‐;  Ortiz;  Javier X. Leon;  David Callaghan;  Gary A. Kendrick;  Oscar Serrano
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/09
Compound climate risks in the COVID-19 pandemic 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (7) : 586-588
作者:  Phillips, Carly A.;  Caldas, Astrid;  Cleetus, Rachel;  Dahl, Kristina A.;  Declet-Barreto, Juan;  Licker, Rachel;  Merner, L. Delta;  Ortiz-Partida, J. Pablo;  Phelan, Alexandra L.;  Spanger-Siegfried, Erika;  Talati, Shuchi;  Trisos, Christopher H.;  Carlson, Colin J.
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/20
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.