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Influence of Land Reclamation on Fresh Groundwater Lenses in Oceanic Islands: Laboratory and Numerical Validation 期刊论文
Water Resources Research, 2021
作者:  Chong Sheng;  Jiu Jimmy Jiao;  Hehua Xu;  Yi Liu;  Xin Luo
收藏  |  浏览/下载:15/0  |  提交时间:2021/09/14
Stabilizing perovskite-substrate interfaces for high-performance perovskite modules 期刊论文
Science, 2021
作者:  Shangshang Chen;  Xuezeng Dai;  Shuang Xu;  Haoyang Jiao;  Liang Zhao;  Jinsong Huang
收藏  |  浏览/下载:9/0  |  提交时间:2021/08/25
An Improved Universal Fusion Algorithm for Constructing 3D Multiscale Porous Media 期刊论文
Water Resources Research, 2021
作者:  Shuaibing Song;  Ming Li;  Qingyi Tu;  Anying Yuan;  Zhenhua Jiao;  Pan Li;  Wenxin Qian;  Hewu Liu;  Nan Xu
收藏  |  浏览/下载:12/0  |  提交时间:2021/08/10
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载:37/0  |  提交时间:2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Unconventional CN vacancies suppress iron-leaching in Prussian blue analogue pre-catalyst for boosted oxygen evolution catalysis 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yu, Zi-You;  Duan, Yu;  Liu, Jian-Dang;  Chen, Yu;  Liu, Xiao-Kang;  Liu, Wei;  Ma, Tao;  Li, Yi;  Zheng, Xu-Sheng;  Yao, Tao;  Gao, Min-Rui;  Zhu, Jun-Fa;  Ye, Bang-Jiao;  Yu, Shu-Hong
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
How does urban population density decline over time? An exponential model for Chinese cities with international comparisons 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 183: 59-67
作者:  Xu, Gang;  Jiao, Limin;  Yuan, Man;  Dong, Ting;  Zhang, Boen;  Du, Chunmeng
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Urbanization  Urban population density  Urban expansion  Population growth  China  
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Xu, Xiaojie;  Fan, Zhongyi;  Liang, Chaoyang;  Li, Ling;  Wang, Lili;  Liang, Yingchun;  Wu, Jun;  Chang, Shaohong;  Yan, Zhifeng;  Lv, Zhaohui;  Fu, Jing;  Liu, Yang;  Jin, Shuai;  Wang, Tao;  Hong, Tian;  Dong, Yishan;  Ding, Lihua;  Cheng, Long;  Liu, Rui;  Fu, Shenbo;  Jiao, Shunchang;  Ye, Qinong
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27