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Ion complexation waves emerge at the curved interfaces of layered minerals 期刊论文
Nature Communications, 2022
作者:  Whittaker, Michael L.;  Ren, David;  Ophus, Colin;  Zhang, Yugang;  Waller, Laura;  Gilbert, Benjamin;  Banfield, Jillian F.
收藏  |  浏览/下载:9/0  |  提交时间:2022/06/24
Extreme heat increases stomatal conductance and drought-induced mortality risk in vulnerable plant species 期刊论文
Global Change Biology, 2021
作者:  René;  e M. Marchin;  Diana Backes;  Alessandro Ossola;  Michelle R. Leishman;  Mark G. Tjoelker;  David S. Ellsworth
收藏  |  浏览/下载:7/0  |  提交时间:2021/11/23
Artificial selection of stable rhizosphere microbiota leads to heritable plant phenotype changes 期刊论文
Ecology Letters, 2021
作者:  Samuel Jacquiod;  Aymé;  Spor;  Shaodong Wei;  Victoria Munkager;  David Bru;  ;  ren J. Sø;  rensen;  Christophe Salon;  Laurent Philippot;  Manuel Blouin
收藏  |  浏览/下载:6/0  |  提交时间:2021/11/15
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome 期刊论文
Science, 2021
作者:  Pramod R. Bhatt;  Alain Scaiola;  Gary Loughran;  Marc Leibundgut;  Annika Kratzel;  Romane Meurs;  René Dreos;  Kate M. O’Connor;  Angus McMillan;  Jeffrey W. Bode;  Volker Thiel;  David Gatfield;  John F. Atkins;  Nenad Ban
收藏  |  浏览/下载:11/0  |  提交时间:2021/06/24
3D genomics across the tree of life reveals condensin II as a determinant of architecture type 期刊论文
Science, 2021
作者:  Claire Hoencamp;  Olga Dudchenko;  Ahmed M. O. Elbatsh;  Sumitabha Brahmachari;  Jonne A. Raaijmakers;  Tom van Schaik;  Ángela Sedeño Cacciatore;  Vinícius G. Contessoto;  Roy G. H. P. van Heesbeen;  Bram van den Broek;  Aditya N. Mhaskar;  Hans Teunissen;  Brian Glenn St Hilaire;  David Weisz;  Arina D. Omer;  Melanie Pham;  Zane Colaric;  Zhenzhen Yang;  Suhas S. P. Rao;  Namita Mitra;  Christopher Lui;  Weijie Yao;  Ruqayya Khan;  Leonid L. Moroz;  Andrea Kohn;  Judy St. Leger;  Alexandria Mena;  Karen Holcroft;  Maria Cristina Gambetta;  Fabian Lim;  Emma Farley;  Nils Stein;  Alexander Haddad;  Daniel Chauss;  Ayse Sena Mutlu;  Meng C. Wang;  Neil D. Young;  Evin Hildebrandt;  Hans H. Cheng;  Christopher J. Knight;  Theresa L. U. Burnham;  Kevin A. Hovel;  Andrew J. Beel;  Pierre-Jean Mattei;  Roger D. Kornberg;  Wesley C. Warren;  Gregory Cary;  José Luis Gómez-Skarmeta;  Veronica Hinman;  Kerstin Lindblad-Toh;  Federica Di Palma;  Kazuhiro Maeshima;  Asha S. Multani;  Sen Pathak;  Liesl Nel-Themaat;  Richard R. Behringer;  Parwinder Kaur;  René H. Medema;  Bas van Steensel;  Elzo de Wit;  José N. Onuchic;  Michele Di Pierro;  Erez Lieberman Aiden;  Benjamin D. Rowland
收藏  |  浏览/下载:12/0  |  提交时间:2021/06/07
Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:24/0  |  提交时间:2021/04/06
Inferring the effectiveness of government interventions against COVID-19 期刊论文
Science, 2021
作者:  Jan M. Brauner;  Sören Mindermann;  Mrinank Sharma;  David Johnston;  John Salvatier;  Tomáš Gavenčiak;  Anna B. Stephenson;  Gavin Leech;  George Altman;  Vladimir Mikulik;  Alexander John Norman;  Joshua Teperowski Monrad;  Tamay Besiroglu;  Hong Ge;  Meghan A. Hartwick;  Yee Whye Teh;  Leonid Chindelevitch;  Yarin Gal;  Jan Kulveit
收藏  |  浏览/下载:10/0  |  提交时间:2021/02/22
Tree mode of death and mortality risk factors across Amazon forests 期刊论文
Nature Communications, 2020
作者:  Adriane Esquivel-Muelbert;  Oliver L. Phillips;  Roel J. W. Brienen;  Sophie Fauset;  Martin J. P. Sullivan;  Timothy R. Baker;  Kuo-Jung Chao;  Ted R. Feldpausch;  Emanuel Gloor;  Niro Higuchi;  Jeanne Houwing-Duistermaat;  Jon Lloyd;  Haiyan Liu;  Yadvinder Malhi;  Beatriz Marimon;  Ben Hur Marimon Junior;  Abel Monteagudo-Mendoza;  Lourens Poorter;  Marcos Silveira;  Emilio Vilanova Torre;  Esteban Alvarez Dá;  vila;  Jhon del Aguila Pasquel;  Everton Almeida;  Patricia Alvarez Loayza;  Ana Andrade;  Luiz E. O. C. Aragã;  o;  Alejandro Araujo-Murakami;  Eric Arets;  Luzmila Arroyo;  Gerardo A. Aymard C.;  Michel Baisie;  Christopher Baraloto;  Plí;  nio Barbosa Camargo;  Jorcely Barroso;  Lilian Blanc;  Damien Bonal;  Frans Bongers;  René;  Boot;  Foster Brown;  Benoit Burban;  José;  Luí;  s Camargo;  Wendeson Castro;  Victor Chama Moscoso;  Jerome Chave;  James Comiskey;  Fernando Cornejo Valverde;  Antonio Lola da Costa;  Nallaret Davila Cardozo;  Anthony Di Fiore;  Auré;  lie Dourdain;  Terry Erwin;  Gerardo Flores Llampazo;  Ima Cé;  lia Guimarã;  es Vieira;  Rafael Herrera;  Eurí;  dice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Eliana Jimenez-Rojas;  Timothy Killeen;  Susan Laurance;  William Laurance;  Aurora Levesley;  Simon L. Lewis;  Karina Liana Lisboa Melgaç;  o Ladvocat;  Gabriela Lopez-Gonzalez;  Thomas Lovejoy;  Patrick Meir;  Casimiro Mendoza;  Paulo Morandi;  David Neill;  Adriano José;  Nogueira Lima;  Percy Nuñ;  ez Vargas;  Edmar Almeida de Oliveira;  Nadir Pallqui Camacho;  Guido Pardo;  Julie Peacock;  Marielos Peñ;  a-Claros;  Maria Cristina Peñ;  uela-Mora;  Georgia Pickavance;  John Pipoly;  Nigel Pitman;  Adriana Prieto;  Thomas A. M. Pugh;  Carlos Quesada;  Hirma Ramirez-Angulo;  Simone Matias de Almeida Reis;  Maxime Rejou-Machain;  Zorayda Restrepo Correa;  Lily Rodriguez Bayona;  Agustí;  n Rudas;  Rafael Salomã;  o;  Julio Serrano;  Javier Silva Espejo;  Natalino Silva;  James Singh;  Clement Stahl;  Juliana Stropp;  Varun Swamy;  Joey Talbot;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Marisol Toledo;  Armando Torres-Lezama;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Meer;  Peter van der Hout;  Rodolfo Vasquez Martinez;  Simone Aparecida Vieira;  Jeanneth Villalobos Cayo;  Vincent Vos;  Roderick Zagt;  Pieter Zuidema;  David Galbraith
收藏  |  浏览/下载:25/0  |  提交时间:2020/11/20
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.