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A noncoding RNA modulator potentiates phenylalanine metabolism in mice 期刊论文
Science, 2021
作者:  Yajuan Li;  Zhi Tan;  Yaohua Zhang;  Zhao Zhang;  Qingsong Hu;  Ke Liang;  Yao Jun;  Youqiong Ye;  Yi-Chuan Li;  Chunlai Li;  Lan Liao;  Jianming Xu;  Zhen Xing;  Yinghong Pan;  Sujash S. Chatterjee;  Tina K. Nguyen;  Heidi Hsiao;  Sergey D. Egranov;  Nagireddy Putluri;  Cristian Coarfa;  David H. Hawke;  Preethi H. Gunaratne;  Kuang-Lei Tsai;  Leng Han;  Mien-Chie Hung;  George A. Calin;  Fares Namour;  Jean-Louis Guéant;  Ania C. Muntau;  Nenad Blau;  V. Reid Sutton;  Manuel Schiff;  François Feillet;  Shuxing Zhang;  Chunru Lin;  Liuqing Yang
收藏  |  浏览/下载：18/0  |  提交时间：2021/08/10
Senolytics reduce coronavirus-related mortality in old mice 期刊论文
Science, 2021
作者:  Christina D. Camell;  Matthew J. Yousefzadeh;  Yi Zhu;  Larissa G. P. Langhi Prata;  Matthew A. Huggins;  Mark Pierson;  Lei Zhang;  Ryan D. O’Kelly;  Tamar Pirtskhalava;  Pengcheng Xun;  Keisuke Ejima;  Ailing Xue;  Utkarsh Tripathi;  Jair Machado Espindola-Netto;  Nino Giorgadze;  Elizabeth J. Atkinson;  Christina L. Inman;  Kurt O. Johnson;  Stephanie H. Cholensky;  Timothy W. Carlson;  Nathan K. LeBrasseur;  Sundeep Khosla;  M. Gerard O’Sullivan;  David B. Allison;  Stephen C. Jameson;  Alexander Meves;  Ming Li;  Y. S. Prakash;  Sergio E. Chiarella;  Sara E. Hamilton;  Tamara Tchkonia;  Laura J. Niedernhofer;  James L. Kirkland;  Paul D. Robbins
收藏  |  浏览/下载：15/0  |  提交时间：2021/07/27
Does the Hook Structure Constrain Future Flood Intensification under Anthropogenic Climate Warming? 期刊论文
Water Resources Research, 2021
作者:  Jiabo Yin;  Shenglian Guo;  Pierre Gentine;  Sylvia C. Sullivan;  Lei Gu;  Shaokun He;  Jie Chen;  Pan Liu
收藏  |  浏览/下载：7/0  |  提交时间：2021/02/17
Latitudinal gradient in the respiration quotient and the implications for ocean oxygen availability 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Allison R. Moreno;  Catherine A. Garcia;  Alyse A. Larkin;  Jenna A. Lee;  Wei-Lei Wang;  J. Keith Moore;  Francois W. Primeau;  Adam C. Martiny
收藏  |  浏览/下载：6/0  |  提交时间：2020/09/08
Corncob cellulose nanosphere as an eco-friendly detergent 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (6) : 448-458
作者:  Liu, Bin;  Li, Tao;  Wang, Wenya;  Sagis, Leonard M. C.;  Yuan, Qipeng;  Lei, Xingen;  Stuart, Martien A. Cohen;  Li, Dan;  Bao, Cheng;  Bai, Jie;  Yu, Zhengquan;  Ren, Fazheng;  Li, Yuan
收藏  |  浏览/下载：12/0  |  提交时间：2020/05/13
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Reversible epitaxial electrodeposition of metals in battery anodes 期刊论文
SCIENCE, 2019, 366 (6465) : 645-+
作者:  Zheng, Jingxu;  Zhao, Qing;  Tang, Tian;  Yin, Jiefu;  Quilty, Calvin D.;  Renderos, Genesis D.;  Liu, Xiaotun;  Deng, Yue;  Wang, Lei;  Bock, David C.;  Jaye, Cherno;  Zhang, Duhan;  Takeuchi, Esther S.;  Takeuchi, Kenneth J.;  Marschilok, Amy C.;  Archer, Lynden A.
收藏  |  浏览/下载：18/0  |  提交时间：2020/02/17
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jiang, Xi;  Hu, Chao;  Ferchen, Kyle;  Nie, Ji;  Cui, Xiaolong;  Chen, Chih-Hong;  Cheng, Liting;  Zuo, Zhixiang;  Seibel, William;  He, Chunjiang;  Tang, Yixuan;  Skibbe, Jennifer R.;  Wunderlich, Mark;  Reinhold, William C.;  Dong, Lei;  Shen, Chao;  Arnovitz, Stephen;  Ulrich, Bryan;  Lu, Jiuwei;  Weng, Hengyou;  Su, Rui;  Huang, Huilin;  Wang, Yungui;  Li, Chenying;  Qin, Xi;  Mulloy, James;  Zheng, Yi;  Diao, Jiajie;  Jin, Jie;  Li, Chong;  Liu, Paul P.;  He, Chuan;  Chen, Yuan;  Chen, Jianjun
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Jones, Greg G.;  del Rio, Isabel Boned;  Sari, Sibel;  Sekerim, Aysen;  Young, Lucy C.;  Hartig, Nicole;  Zubiaur, Itziar Areso;  El-Bahrawy, Mona A.;  Hynds, Rob E.;  Lei, Winnie;  Molina-Arcas, Miriam;  Downward, Julian;  Rodriguez-Viciana, Pablo
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Historical and genomic data reveal the influencing factors on global transmission velocity of plague during the Third Pandemic 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (24) : 11833-11838
作者:  Xu, Lei;  Stige, Leif C.;  Leirs, Herwig;  Neerinckx, Simon;  Gage, Kenneth L.;  Yang, Ruifu;  Liu, Qiyong;  Bramanti, Barbara;  Dean, Katharine R.;  Tang, Hui;  Sun, Zhe;  Stenseth, Nils Chr.;  Zhang, Zhibin
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Yersinia pestis  Third Pandemic  climate change  global transmission velocity  historical and genomic data