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Intracontinental deformation of the Tianshan Orogen in response to India-Asia collision 期刊论文
Nature Communications, 2022
作者:  Li, Wei;  Chen, Yun;  Yuan, Xiaohui;  Xiao, Wenjiao;  Windley, Brian F.
收藏  |  浏览/下载：21/0  |  提交时间：2022/07/08
Global cooling induced by biophysical effects of bioenergy crop cultivation 期刊论文
Nature Communications, 2021
作者:  Wang, Jingmeng;  Li, Wei;  Ciais, Philippe;  Li, Laurent Z. X.;  Chang, Jinfeng;  Goll, Daniel;  Gasser, Thomas;  Huang, Xiaomeng;  Devaraju, Narayanappa;  Boucher, Olivier
收藏  |  浏览/下载：19/0  |  提交时间：2022/01/14
PNAS研究分析北极海冰的自然变化趋势 快报文章
资源环境快报，2020年第20期
作者:  王立伟
Microsoft Word(18Kb)  |  收藏  |  浏览/下载：424/0  |  提交时间：2020/11/02
Arctic  sea ice  ocean warming  
GRID-Arendal发布《北极沿海和近海多年冻土变化评估报告》 快报文章
资源环境快报，2020年第20期
作者:  王立伟
Microsoft Word(20Kb)  |  收藏  |  浏览/下载：437/3  |  提交时间：2020/11/02
Arctic  frozen soil  climate change  
Substrate regulation leads to differential responses of microbial ammonia-oxidizing communities to ocean warming 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Zheng, Zhen-Zhen;  Zheng, Li-Wei;  Xu, Min Nina;  Tan, Ehui;  Hutchins, David A.;  Deng, Wenchao;  Zhang, Yao;  Shi, Dalin;  Dai, Minhan;  Kao, Shuh-Ji
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/21
Short-lived climate forcers have long-term climate impacts via the carbon-climate feedback 期刊论文
NATURE CLIMATE CHANGE, 2020
作者:  Fu, Bo;  Gasser, Thomas;  Li, Bengang;  Tao, Shu;  Ciais, Philippe;  Piao, Shilong;  Balkanski, Yves;  Li, Wei;  Yin, Tianya;  Han, Luchao;  Li, Xinyue;  Han, Yunman;  An, Jie;  Peng, Siyuan;  Xu, Jing
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/21
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Increased control of vegetation on global terrestrial energy fluxes 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (4) : 356-+
作者:  Forzieri, Giovanni;  Miralles, Diego G.;  Ciais, Philippe;  Alkama, Ramdane;  Ryu, Youngryel;  Duveiller, Gregory;  Zhang, Ke;  Robertson, Eddy;  Kautz, Markus;  Martens, Brecht;  Jiang, Chongya;  Arneth, Almut;  Georgievski, Goran;  Li, Wei;  Ceccherini, Guido;  Anthoni, Peter;  Lawrence, Peter;  Wiltshire, Andy;  Pongratz, Julia;  Piao, Shilong;  Sitch, Stephen;  Goll, Daniel S.;  Arora, Vivek K.;  Lienert, Sebastian;  Lombardozzi, Danica;  Kato, Etsushi;  Nabel, Julia E. M. S.;  Tian, Hanqin;  Friedlingstein, Pierre;  Cescatti, Alessandro
收藏  |  浏览/下载：15/0  |  提交时间：2020/05/13
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tao, Chunhui;  Seyfried, W. E., Jr.;  Lowell, R. P.;  Liu, Yunlong;  Liang, Jin;  Guo, Zhikui;  Ding, Kang;  Zhang, Huatian;  Liu, Jia;  Qiu, Lei;  Egorov, Igor;  Liao, Shili;  Zhao, Minghui;  Zhou, Jianping;  Deng, Xianming;  Li, Huaiming;  Wang, Hanchuang;  Cai, Wei;  Zhang, Guoyin;  Zhou, Hongwei;  Lin, Jian;  Li, Wei
收藏  |  浏览/下载：19/0  |  提交时间：2020/05/13
古老的南极冰盖融化会使海平面上升超过3米 快报文章
资源环境快报，2020年第4期
作者:  王立伟
Microsoft Word(17Kb)  |  收藏  |  浏览/下载：375/0  |  提交时间：2020/02/29