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The impact of global dimming on crop yields is determined by the source–sink imbalance of carbon during grain filling 期刊论文
Global Change Biology, 2020
作者:  Liping Shao;  Zijuan Liu;  Haozheng Li;  Yaling Zhang;  Mingming Dong;  Xuanhe Guo;  Han Zhang;  Baowei Huang;  Rongbing Ni;  Gang Li;  Chuang Cai;  Weiping Chen;  Weihong Luo;  Xinyou Yin
收藏  |  浏览/下载:5/0  |  提交时间:2020/12/07
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase 期刊论文
Science, 2020
作者:  Hai Zheng;  Yilun Qi;  Shibin Hu;  Xuan Cao;  Congling Xu;  Zhinang Yin;  Xizi Chen;  Yan Li;  Weida Liu;  Jie Li;  Jiawei Wang;  Gang Wei;  Kaiwei Liang;  Fei Xavier Chen;  Yanhui Xu
收藏  |  浏览/下载:11/0  |  提交时间:2020/11/30
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail 期刊论文
Science, 2020
作者:  Johanna Hansen;  Alina Baum;  Kristen E. Pascal;  Vincenzo Russo;  Stephanie Giordano;  Elzbieta Wloga;  Benjamin O. Fulton;  Ying Yan;  Katrina Koon;  Krunal Patel;  Kyung Min Chung;  Aynur Hermann;  Erica Ullman;  Jonathan Cruz;  Ashique Rafique;  Tammy Huang;  Jeanette Fairhurst;  Christen Libertiny;  Marine Malbec;  Wen-yi Lee;  Richard Welsh;  Glen Farr;  Seth Pennington;  Dipali Deshpande;  Jemmie Cheng;  Anke Watty;  Pascal Bouffard;  Robert Babb;  Natasha Levenkova;  Calvin Chen;  Bojie Zhang;  Annabel Romero Hernandez;  Kei Saotome;  Yi Zhou;  Matthew Franklin;  Sumathi Sivapalasingam;  David Chien Lye;  Stuart Weston;  James Logue;  Robert Haupt;  Matthew Frieman;  Gang Chen;  William Olson;  Andrew J. Murphy;  Neil Stahl;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/25
Giant thermopower of ionic gelatin near room temperature 期刊论文
Science, 2020
作者:  Cheng-Gong Han;  Xin Qian;  Qikai Li;  Biao Deng;  Yongbin Zhu;  Zhijia Han;  Wenqing Zhang;  Weichao Wang;  Shien-Ping Feng;  Gang Chen;  Weishu Liu
收藏  |  浏览/下载:10/0  |  提交时间:2020/06/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Mott and generalized Wigner crystal states in WSe2/WS2 moire superlattices 期刊论文
NATURE, 2020, 579 (7799) : 359-+
作者:  Yuan, Jie;  Chang, Si-Yuan;  Yin, Shi-Gang;  Liu, Zhi-Yang;  Cheng, Xiu;  Liu, Xi-Juan;  Jiang, Qiang;  Gao, Ge;  Lin, De-Ying;  Kang, Xin-Lei;  Ye, Shi-Wei;  Chen, Zheng;  Yin, Jiang-An;  Hao, Pei;  Jiang, Lubin;  Cai, Shi-Qing
收藏  |  浏览/下载:50/0  |  提交时间:2020/07/03

Strongly correlated insulating Mott and generalized Wigner phases are detected in WSe2/WS2 moire superlattices, and their electrical properties and excited spin states are studied using an optical technique.


Moire superlattices can be used to engineer strongly correlated electronic states in two-dimensional van der Waals heterostructures, as recently demonstrated in the correlated insulating and superconducting states observed in magic-angle twisted-bilayer graphene and ABC trilayer graphene/boron nitride moire superlattices(1-4). Transition metal dichalcogenide moire heterostructures provide another model system for the study of correlated quantum phenomena(5) because of their strong light-matter interactions and large spin-orbit coupling. However, experimental observation of correlated insulating states in this system is challenging with traditional transport techniques. Here we report the optical detection of strongly correlated phases in semiconducting WSe2/WS2 moire superlattices. We use a sensitive optical detection technique and reveal a Mott insulator state at one hole per superlattice site and surprising insulating phases at 1/3 and 2/3 filling of the superlattice, which we assign to generalized Wigner crystallization on the underlying lattice(6-11). Furthermore, the spin-valley optical selection rules(12-14) of transition metal dichalcogenide heterostructures allow us to optically create and investigate low-energy excited spin states in the Mott insulator. We measure a very long spin relaxation lifetime of many microseconds in the Mott insulating state, orders of magnitude longer than that of charge excitations. Our studies highlight the value of using moire superlattices beyond graphene to explore correlated physics.


  
The acclimation of leaf photosynthesis of wheat and rice to seasonal temperature changes in T-FACE environments 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Cai, Chuang;  Li, Gang;  Di, Lijun;  Ding, Yunjie;  Fu, Lin;  Guo, Xuanhe;  Struik, Paul C.;  Pan, Genxing;  Li, Haozheng;  Chen, Weiping;  Luo, Weihong;  Yin, Xinyou
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
climate change  free-air CO2 enrichment  growth temperature  leaf nitrogen content  Oryza sativa L  photosynthesis model  stomatal conductance  Triticum aestivum L  
Shisa7 isa GABA(A) receptor auxiliary subunit controlling benzodiazepine actions 期刊论文
SCIENCE, 2019, 366 (6462) : 246-+
作者:  Han, Wenyan;  Li, Jun;  Pelkey, Kenneth A.;  Pandey, Saurabh;  Chen, Xiumin;  Wang, Ya-Xian;  Wu, Kunwei;  Ge, Lihao;  Li, Tianming;  Castellano, David;  Liu, Chengyu;  Wu, Ling-Gang;  Petralia, Ronald S.;  Lynch, Joseph W.;  McBain, Chris J.;  Lu, Wei
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27