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Tropical tall forests are more sensitive and vulnerable to drought than short forests 期刊论文
Global Change Biology, 2021
作者:  Liyang Liu;  Xiuzhi Chen;  Philippe Ciais;  Wenping Yuan;  Fabienne Maignan;  Jin Wu;  Shilong Piao;  Ying-Ping Wang;  Jean-Pierre Wigneron;  Lei Fan;  Pierre Gentine;  Xueqin Yang;  Fanxi Gong;  Hui Liu;  Chen Wang;  Xuli Tang;  Hui Yang;  Qing Ye;  Bin He;  Jiali Shang;  Yongxian Su
收藏  |  浏览/下载:16/0  |  提交时间:2021/12/15
Differential effects of altered precipitation regimes on soil carbon cycles in arid versus humid terrestrial ecosystems 期刊论文
Global Change Biology, 2021
作者:  Bin Wang;  Yali Chen;  Yan Li;  Hui Zhang;  Kai Yue;  Xingchang Wang;  Yuandan Ma;  Jian Chen;  Meng Sun;  Zhuo Chen;  Qiqian Wu
收藏  |  浏览/下载:11/0  |  提交时间:2021/10/07
Phosphorus rather than nitrogen regulates ecosystem carbon dynamics after permafrost thaw 期刊论文
Global Change Biology, 2021
作者:  Guibiao Yang;  Yunfeng Peng;  Benjamin W. Abbott;  Christina Biasi;  Bin Wei;  Dianye Zhang;  Jun Wang;  Jianchun Yu;  Fei Li;  Guanqin Wang;  Dan Kou;  Futing Liu;  Yuanhe Yang
收藏  |  浏览/下载:14/0  |  提交时间:2021/08/30
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity 期刊论文
Science, 2021
作者:  Wei Hui;  Lingfeng Chao;  Hui Lu;  Fei Xia;  Qi Wei;  Zhenhuang Su;  Tingting Niu;  Lei Tao;  Bin Du;  Deli Li;  Yue Wang;  He Dong;  Shouwei Zuo;  Bixin Li;  Wei Shi;  Xueqin Ran;  Ping Li;  Hui Zhang;  Zhongbin Wu;  Chenxin Ran;  Lin Song;  Guichuan Xing;  Xingyu Gao;  Jing Zhang;  Yingdong Xia;  Yonghua Chen;  Wei Huang
收藏  |  浏览/下载:22/0  |  提交时间:2021/04/06
Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair 期刊论文
Science, 2021
作者:  Lingjuan He;  Wenjuan Pu;  Xiuxiu Liu;  Zhenqian Zhang;  Maoying Han;  Yi Li;  Xiuzhen Huang;  Ximeng Han;  Yan Li;  Kuo Liu;  Mengyang Shi;  Liang Lai;  Ruilin Sun;  Qing-Dong Wang;  Yong Ji;  Jan S. Tchorz;  Bin Zhou
收藏  |  浏览/下载:33/0  |  提交时间:2021/03/02
Determining structural and chemical heterogeneities of surface species at the single-bond limit 期刊论文
Science, 2021
作者:  Jiayu Xu;  Xiang Zhu;  Shijing Tan;  Yao Zhang;  Bin Li;  Yunzhe Tian;  Huan Shan;  Xuefeng Cui;  Aidi Zhao;  Zhenchao Dong;  Jinlong Yang;  Yi Luo;  Bing Wang;  J. G. Hou
收藏  |  浏览/下载:13/0  |  提交时间:2021/02/22
Chloride-mediated selective electrosynthesis of ethylene and propylene oxides at high current density 期刊论文
Science, 2020
作者:  Wan Ru Leow;  Yanwei Lum;  Adnan Ozden;  Yuhang Wang;  Dae-Hyun Nam;  Bin Chen;  Joshua Wicks;  Tao-Tao Zhuang;  Fengwang Li;  David Sinton;  Edward H. Sargent
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/16
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China 期刊论文
Science, 2020
作者:  Huaiyu Tian;  Yonghong Liu;  Yidan Li;  Chieh-Hsi Wu;  Bin Chen;  Moritz U. G. Kraemer;  Bingying Li;  Jun Cai;  Bo Xu;  Qiqi Yang;  Ben Wang;  Peng Yang;  Yujun Cui;  Yimeng Song;  Pai Zheng;  Quanyi Wang;  Ottar N. Bjornstad;  Ruifu Yang;  Bryan T. Grenfell;  Oliver G. Pybus;  Christopher Dye
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
Depth‐dependent soil organic carbon dynamics of croplands across the Chengdu Plain of China from the 1980s to the 2010s 期刊论文
Global Change Biology, 2020
作者:  Qiquan Li;  Aiwen Li;  Tianfei Dai;  Zemeng Fan;  Youlin Luo;  Shan Li;  Dagang Yuan;  Bin Zhao;  Qi Tao;  Changquan Wang;  Bing Li;  Xuesong Gao;  Yiding Li;  Huanxiu Li;  John P. Wilson
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.