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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载：17/0  |  提交时间：2021/04/06
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
Science, 2020
作者:  Lu Zhang;  Yao Zhao;  Yan Gao;  Lijie Wu;  Ruogu Gao;  Qi Zhang;  Yinan Wang;  Chengyao Wu;  Fangyu Wu;  Sudagar S. Gurcha;  Natacha Veerapen;  Sarah M. Batt;  Wei Zhao;  Ling Qin;  Xiuna Yang;  Manfu Wang;  Yan Zhu;  Bing Zhang;  Lijun Bi;  Xian’en Zhang;  Haitao Yang;  Luke W. Guddat;  Wenqing Xu;  Quan Wang;  Jun Li;  Gurdyal S. Besra;  Zihe Rao
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/16
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载：16/0  |  提交时间：2020/05/20
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Future haze events in Beijing, China: When climate warms by 1.5 and 2.0 degrees C 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Liu, Cuiping;  Zhang, Feng;  Miao, Lijuan;  Lei, Yadong;  Yang, Quan
收藏  |  浏览/下载：13/0  |  提交时间：2020/02/17
1  5 degrees C  2  0 degrees C  China  CMIP5  global warming  haze  
Different contributions of Arctic sea ice anomalies from different regions to North China summer ozone pollution 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Yin, Zhicong;  Yuan, Dongmin;  Zhang, Xinyu;  Yang, Quan;  Xia, Shuwei
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
Arctic sea ice  Eurasia teleconnection  ozone pollution  photochemical reaction  west Pacific pattern  
Large-area graphene-nanomesh/carbon-nanotube hybrid membranes for ionic and molecular nanofiltration 期刊论文
SCIENCE, 2019, 364 (6445) : 1057-+
作者:  Yang, Yanbing;  Yang, Xiangdong;  Liang, Ling;  Gao, Yuyan;  Cheng, Huanyu;  Li, Xinming;  Zou, Mingchu;  Cao, Anyuan;  Ma, Renzhi;  Yuan, Quan;  Duan, Xiangfeng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex 期刊论文
SCIENCE, 2018, 362 (6418) : 1020-+
作者:  Gong, Hongri;  Li, Jun;  Xu, Ao;  Tang, Yanting;  Ji, Wenxin;  Gao, Ruogu;  Wang, Shuhui;  Yu, Lu;  Tian, Changlin;  Li, Jingwen;  Yen, Hsin-Yung;  Lam, Sin Man;  Shui, Guanghou;  Yang, Xiuna;  Sun, Yuna;  Li, Xuemei;  Jia, Minze;  Yang, Cheng;  Jiang, Biao;  Lou, Zhiyong;  Robinson, Carol V.;  Wong, Luet-Lok;  Guddat, Luke W.;  Sun, Fei;  Wang, Quan;  Rao, Zihe
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
Ground-to-satellite quantum teleportation 期刊论文
NATURE, 2017, 549 (7670) : 70-+
作者:  Ren, Ji-Gang;  Xu, Ping;  Yong, Hai-Lin;  Zhang, Liang;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Yang, Meng;  Li, Li;  Yang, Kui-Xing;  Han, Xuan;  Yao, Yong-Qiang;  Li, Ji;  Wu, Hai-Yan;  Wan, Song;  Liu, Lei;  Liu, Ding-Quan;  Kuang, Yao-Wu;  He, Zhi-Ping;  Shang, Peng;  Guo, Cheng;  Zheng, Ru-Hua;  Tian, Kai;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Lu, Chao-Yang;  Shu, Rong;  Chen, Yu-Ao;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Anthropogenic pollution elevates the peak height of new particle formation from planetary boundary layer to lower free troposphere 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (14)
作者:  Quan, Jiannong;  Liu, Yangang;  Liu, Quan;  Jia, Xingcan;  Li, Xia;  Gao, Yang;  Ding, Deping;  Li, Jie;  Wang, Zifa
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09