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DOI | 10.1126/science.aat8923 |
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex | |
Gong, Hongri1,2; Li, Jun3,4; Xu, Ao1,2,5; Tang, Yanting1,2; Ji, Wenxin5,6; Gao, Ruogu5,6; Wang, Shuhui3,4; Yu, Lu7; Tian, Changlin7,8,9; Li, Jingwen10; Yen, Hsin-Yung10,11; Lam, Sin Man12; Shui, Guanghou12; Yang, Xiuna3,4; Sun, Yuna5; Li, Xuemei5; Jia, Minze5; Yang, Cheng1,2; Jiang, Biao3; Lou, Zhiyong13; Robinson, Carol V.10; Wong, Luet-Lok14; Guddat, Luke W.15; Sun, Fei5,6; Wang, Quan5; Rao, Zihe1,2,3,4,5,13 | |
2018-11-30 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6418页码:1020-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; England; Australia |
英文摘要 | We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451609000036 |
WOS关键词 | CYTOCHROME-C-OXIDASE ; CU,ZN SUPEROXIDE-DISMUTASE ; BEAM-INDUCED MOTION ; PARACOCCUS-DENITRIFICANS ; CRYSTAL-STRUCTURE ; SUPRAMOLECULAR ORGANIZATION ; CORYNEBACTERIUM-GLUTAMICUM ; TERMINAL OXIDASE ; COMPLEX ; TUBERCULOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200198 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300353, Peoples R China; 2.Nankai Univ, Coll Life Sci, Tianjin 300353, Peoples R China; 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China; 6.Univ Chinese Acad Sci, Beijing, Peoples R China; 7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China; 8.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China; 9.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China; 10.Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, South Parks Rd, Oxford OX1 3QZ, England; 11.OMass Technol, Begbroke Sci Pk,Woodstock Rd, Yarnton OX5 1PF, Kidlington, England; 12.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China; 13.Tsinghua Univ, Lab Struct Biol, Beijing 100084, Peoples R China; 14.Univ Oxford, Inorgan Chem Lab, Dept Chem, South Parks Rd, Oxford OX1 3QR, England; 15.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia |
推荐引用方式 GB/T 7714 | Gong, Hongri,Li, Jun,Xu, Ao,et al. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex[J]. SCIENCE,2018,362(6418):1020-+. |
APA | Gong, Hongri.,Li, Jun.,Xu, Ao.,Tang, Yanting.,Ji, Wenxin.,...&Rao, Zihe.(2018).An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE,362(6418),1020-+. |
MLA | Gong, Hongri,et al."An electron transfer path connects subunits of a mycobacterial respiratory supercomplex".SCIENCE 362.6418(2018):1020-+. |
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