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Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity 期刊论文
Science, 2021
作者:  Wei Hui;  Lingfeng Chao;  Hui Lu;  Fei Xia;  Qi Wei;  Zhenhuang Su;  Tingting Niu;  Lei Tao;  Bin Du;  Deli Li;  Yue Wang;  He Dong;  Shouwei Zuo;  Bixin Li;  Wei Shi;  Xueqin Ran;  Ping Li;  Hui Zhang;  Zhongbin Wu;  Chenxin Ran;  Lin Song;  Guichuan Xing;  Xingyu Gao;  Jing Zhang;  Yingdong Xia;  Yonghua Chen;  Wei Huang
收藏  |  浏览/下载:22/0  |  提交时间:2021/04/06
Depth‐dependent soil organic carbon dynamics of croplands across the Chengdu Plain of China from the 1980s to the 2010s 期刊论文
Global Change Biology, 2020
作者:  Qiquan Li;  Aiwen Li;  Tianfei Dai;  Zemeng Fan;  Youlin Luo;  Shan Li;  Dagang Yuan;  Bin Zhao;  Qi Tao;  Changquan Wang;  Bing Li;  Xuesong Gao;  Yiding Li;  Huanxiu Li;  John P. Wilson
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Anomalous Sound Velocities of Antigorite at High Pressure and Implications for Detecting Serpentinization at Mantle Wedges 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (10) : 5153-5160
作者:  Wang, Duojun;  Liu, Tao;  Chen, Ting;  Qi, Xintong;  Li, Baosheng
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
Snow Hydrology in the Upper Yellow River Basin Under Climate Change: A Land Surface Modeling Perspective 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (22) : 12676-12691
作者:  Liu, Wenbin;  Wang, Lei;  Sun, Fubao;  Li, Zehua;  Wang, Hong;  Liu, Jiahong;  Yang, Tao;  Zhou, Jing;  Qi, Jia
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Observed Variation of Three-Dimensional Return Stroke Speeds Along the Channel in Rocket-Triggered Lightning 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (22) : 12569-12575
作者:  Li, Yun;  Qiu, Shi;  Shi, Lihua;  Wang, Tao;  Zhang, Qi;  Lei, Qi;  Sun, Zheng
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Resonant Scattering of Near-Equatorially Mirroring Electrons by Landau Resonance With H+ Band EMIC Waves 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (20) : 10866-10873
作者:  Fu, Song;  Ni, Binbin;  Lou, Yuequn;  Bortnik, Jacob;  Ge, Yasong;  Tao, Xin;  Cao, Xing;  Gu, Xudong;  Xiang, Zheng;  Zhang, Wenxun;  Zhang, Yang;  Wang, Qi
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Stratosphere Perturbed by the 2011 Mw9.0 Tohoku Earthquake 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (19) : 10050-10056
作者:  Yan, Xiangxiang;  Sun, Yangyi;  Yu, Tao;  Liu, Jann-Yenq;  Qi, Yifan;  Xia, Chunliang;  Zuo, Xiaomin;  Yang, Na
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
Precipitation characteristics over the steep slope of the Himalayas in rainy season observed by TRMM PR and VIRS 期刊论文
CLIMATE DYNAMICS, 2018, 51: 1971-1989
作者:  Fu, Yunfei;  Pan, Xiao;  Xian, Tao;  Liu, Guosheng;  Zhong, Lei;  Liu, Qi;  Li, Rui;  Wang, Yu;  Ma, Ming
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Precipitation  Steep Himalayas  Elevation  Relief  TRMM merged data