中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共35条，第1-10条 帮助

限定条件                    
已选(0)清除 条数/页：   排序方式：
Wafer-scale heterostructured piezoelectric bio-organic thin films 期刊论文
Science, 2021
作者:  Fan Yang;  Jun Li;  Yin Long;  Ziyi Zhang;  Linfeng Wang;  Jiajie Sui;  Yutao Dong;  Yizhan Wang;  Rachel Taylor;  Dalong Ni;  Weibo Cai;  Ping Wang;  Timothy Hacker;  Xudong Wang
收藏  |  浏览/下载：17/0  |  提交时间：2021/07/27
Long-term nitrogen input alters plant and soil bacterial, but not fungal beta diversity in a semiarid grassland 期刊论文
Global Change Biology, 2021
作者:  Weixing Liu;  Lingli Liu;  Xian Yang;  Meifeng Deng;  Zhou Wang;  Pandeng Wang;  Sen Yang;  Ping Li;  Ziyang Peng;  Lu Yang;  Lin Jiang
收藏  |  浏览/下载：9/0  |  提交时间：2021/06/07
A widespread pathway for substitution of adenine by diaminopurine in phage genomes 期刊论文
Science, 2021
作者:  Yan Zhou;  Xuexia Xu;  Yifeng Wei;  Yu Cheng;  Yu Guo;  Ivan Khudyakov;  Fuli Liu;  Ping He;  Zhangyue Song;  Zhi Li;  Yan Gao;  Ee Lui Ang;  Huimin Zhao;  Yan Zhang;  Suwen Zhao
收藏  |  浏览/下载：14/0  |  提交时间：2021/05/07
Stabilizing black-phase formamidinium perovskite formation at room temperature and high humidity 期刊论文
Science, 2021
作者:  Wei Hui;  Lingfeng Chao;  Hui Lu;  Fei Xia;  Qi Wei;  Zhenhuang Su;  Tingting Niu;  Lei Tao;  Bin Du;  Deli Li;  Yue Wang;  He Dong;  Shouwei Zuo;  Bixin Li;  Wei Shi;  Xueqin Ran;  Ping Li;  Hui Zhang;  Zhongbin Wu;  Chenxin Ran;  Lin Song;  Guichuan Xing;  Xingyu Gao;  Jing Zhang;  Yingdong Xia;  Yonghua Chen;  Wei Huang
收藏  |  浏览/下载：22/0  |  提交时间：2021/04/06
Role of iodine oxoacids in atmospheric aerosol nucleation 期刊论文
Science, 2021
作者:  Xu-Cheng He;  Yee Jun Tham;  Lubna Dada;  Mingyi Wang;  Henning Finkenzeller;  Dominik Stolzenburg;  Siddharth Iyer;  Mario Simon;  Andreas Kürten;  Jiali Shen;  Birte Rörup;  Matti Rissanen;  Siegfried Schobesberger;  Rima Baalbaki;  Dongyu S. Wang;  Theodore K. Koenig;  Tuija Jokinen;  Nina Sarnela;  Lisa J. Beck;  João Almeida;  Stavros Amanatidis;  António Amorim;  Farnoush Ataei;  Andrea Baccarini;  Barbara Bertozzi;  Federico Bianchi;  Sophia Brilke;  Lucía Caudillo;  Dexian Chen;  Randall Chiu;  Biwu Chu;  António Dias;  Aijun Ding;  Josef Dommen;  Jonathan Duplissy;  Imad El Haddad;  Loïc Gonzalez Carracedo;  Manuel Granzin;  Armin Hansel;  Martin Heinritzi;  Victoria Hofbauer;  Heikki Junninen;  Juha Kangasluoma;  Deniz Kemppainen;  Changhyuk Kim;  Weimeng Kong;  Jordan E. Krechmer;  Aleksander Kvashin;  Totti Laitinen;  Houssni Lamkaddam;  Chuan Ping Lee;  Katrianne Lehtipalo;  Markus Leiminger;  Zijun Li;  Vladimir Makhmutov;  Hanna E. Manninen;  Guillaume Marie;  Ruby Marten;  Serge Mathot;  Roy L. Mauldin;  Bernhard Mentler;  Ottmar Möhler;  Tatjana Müller;  Wei Nie;  Antti Onnela;  Tuukka Petäjä;  Joschka Pfeifer;  Maxim Philippov;  Ananth Ranjithkumar;  Alfonso Saiz-Lopez;  Imre Salma;  Wiebke Scholz;  Simone Schuchmann;  Benjamin Schulze;  Gerhard Steiner;  Yuri Stozhkov;  Christian Tauber;  António Tomé;  Roseline C. Thakur;  Olli Väisänen;  Miguel Vazquez-Pufleau;  Andrea C. Wagner;  Yonghong Wang;  Stefan K. Weber;  Paul M. Winkler;  Yusheng Wu;  Mao Xiao;  Chao Yan;  Qing Ye;  Arttu Ylisirniö;  Marcel Zauner-Wieczorek;  Qiaozhi Zha;  Putian Zhou;  Richard C. Flagan;  Joachim Curtius;  Urs Baltensperger;  Markku Kulmala;  Veli-Matti Kerminen;  Theo Kurtén;  Neil M. Donahue;  Rainer Volkamer;  Jasper Kirkby;  Douglas R. Worsnop;  Mikko Sipilä
收藏  |  浏览/下载：11/0  |  提交时间：2021/02/17
Control of long-distance motion of single molecules on a surface 期刊论文
Science, 2020
作者:  Donato Civita;  Marek Kolmer;  Grant J. Simpson;  An-Ping Li;  Stefan Hecht;  Leonhard Grill
收藏  |  浏览/下载：3/0  |  提交时间：2020/11/24
Rational synthesis of atomically precise graphene nanoribbons directly on metal oxide surfaces 期刊论文
Science, 2020
作者:  Marek Kolmer;  Ann-Kristin Steiner;  Irena Izydorczyk;  Wonhee Ko;  Mads Engelund;  Marek Szymonski;  An-Ping Li;  Konstantin Amsharov
收藏  |  浏览/下载：1/0  |  提交时间：2020/08/09
Metalens-array–based high-dimensional and multiphoton quantum source 期刊论文
Science, 2020
作者:  Lin Li;  Zexuan Liu;  Xifeng Ren;  Shuming Wang;  Vin-Cent Su;  Mu-Ku Chen;  Cheng Hung Chu;  Hsin Yu Kuo;  Biheng Liu;  Wenbo Zang;  Guangcan Guo;  Lijian Zhang;  Zhenlin Wang;  Shining Zhu;  Din Ping Tsai
收藏  |  浏览/下载：14/0  |  提交时间：2020/06/29
Giant thermopower of ionic gelatin near room temperature 期刊论文
Science, 2020
作者:  Cheng-Gong Han;  Xin Qian;  Qikai Li;  Biao Deng;  Yongbin Zhu;  Zhijia Han;  Wenqing Zhang;  Weichao Wang;  Shien-Ping Feng;  Gang Chen;  Weishu Liu
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/09
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.