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Dietary modifications for enhanced cancer therapy 期刊论文
NATURE, 2020, 579 (7800) : 507-517
作者:  Keller, Matthew D.;  Ching, Krystal L.;  Liang, Feng-Xia;  Dhabaria, Avantika;  Tam, Kayan;  Ueberheide, Beatrix M.;  Unutmaz, Derya;  Torres, Victor J.;  Cadwell, Ken
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/03

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host'  s diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.


  
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (vol 551, pg 629, 2017) 期刊论文
NATURE, 2020, 580 (7802) : E5-E5
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/03
Nightside condensation of iron in an ultrahot giant exoplanet 期刊论文
NATURE, 2020, 580 (7805) : 597-+
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载：57/0  |  提交时间：2020/07/03

Ultrahot giant exoplanets receive thousands of times Earth'  s insolation(1,2). Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry(3-5). Daysides are predicted to be cloud-free, dominated by atomic species(6) and much hotter than nightsides(5,7,8). Atoms are expected to recombine into molecules over the nightside(9), resulting in different day and night chemistries. Although metallic elements and a large temperature contrast have been observed(10-14), no chemical gradient has been measured across the surface of such an exoplanet. Different atmospheric chemistry between the day-to-night ('  evening'  ) and night-to-day ('  morning'  ) terminators could, however, be revealed as an asymmetric absorption signature during transit(4,7,15). Here we report the detection of an asymmetric atmospheric signature in the ultrahot exoplanet WASP-76b. We spectrally and temporally resolve this signature using a combination of high-dispersion spectroscopy with a large photon-collecting area. The absorption signal, attributed to neutral iron, is blueshifted by -11 +/- 0.7 kilometres per second on the trailing limb, which can be explained by a combination of planetary rotation and wind blowing from the hot dayside(16). In contrast, no signal arises from the nightside close to the morning terminator, showing that atomic iron is not absorbing starlight there. We conclude that iron must therefore condense during its journey across the nightside.


Absorption lines of iron in the dayside atmosphere of an ultrahot giant exoplanet disappear after travelling across the nightside, showing that the iron has condensed during its travel.


  
AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate 期刊论文
SCIENCE, 2019, 363 (6431) : 1085-+
作者:  Gu, Qilin;  Yang, Xiaojie;  Lv, Jie;  Zhang, Jiaxiong;  Xia, Bo;  Kim, Jun-dae;  Wang, Ruoyu;  Xiong, Feng;  Meng, Shu;  Clements, Thomas P.;  Tandon, Bhavna;  Wagner, Daniel S.;  Diaz, Miguel F.;  Wenzel, Pamela L.;  Miller, Yury I.;  Traver, David;  Cooke, John P.;  Li, Wenbo;  Zon, Leonard I.;  Chen, Kaifu;  Bai, Yongping;  Fang, Longhou
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder 期刊论文
SCIENCE, 2018, 362 (6420) : 1265-+
作者:  Gandal, Michael J.;  Zhang, Pan;  Hadjimichael, Evi;  Walker, Rebecca L.;  Chen, Chao;  Liu, Shuang;  Won, Hyejung;  van Bakel, Harm;  Varghese, Merina;  Wang, Yongjun;  Shieh, Annie W.;  Haney, Jillian;  Parhami, Sepideh;  Belmont, Judson;  Kim, Minsoo;  Losada, Patricia Moran;  Khan, Zenab;  Mleczko, Justyna;  Xia, Yan;  Dai, Rujia;  Wang, Daifeng;  Yang, Yucheng T.;  Xu, Min;  Fish, Kenneth;  Hof, Patrick R.;  Warrell, Jonathan;  Fitzgerald, Dominic;  White, Kevin;  Jaffe, Andrew E.;  Peters, Mette A.;  Gerstein, Mark;  Liu, Chunyu;  Iakoucheva, Lilia M.;  Pinto, Dalila;  Geschwind, Daniel H.
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
A high-energy-density lithium-oxygen battery based on a reversible four-electron conversion to lithium oxide 期刊论文
SCIENCE, 2018, 361 (6404) : 777-781
作者:  Xia, C.;  Kwok, C. Y.;  Nazar, L. F.
收藏  |  浏览/下载：2/0  |  提交时间：2019/11/27
Co-regulatory networks of human serum proteins link genetics to disease 期刊论文
SCIENCE, 2018, 361 (6404) : 769-773
作者:  Emilsson, Valur;  Ilkov, Marjan;  Lamb, John R.;  Finkel, Nancy;  Gudmundsson, Elias F.;  Pitts, Rebecca;  Hoover, Heather;  Gudmundsdottir, Valborg;  Horman, Shane R.;  Aspelund, Thor;  Shu, Le;  Trifonov, Vladimir;  Sigurdsson, Sigurdur;  Manolescu, Andrei;  Zhu, Jun;  Olafsson, Orn;  Jakobsdottir, Johanna;  Lesley, Scott A.;  To, Jeremy;  Zhang, Jia;  Harris, Tamara B.;  Launer, Lenore J.;  Zhang, Bin;  Eiriksdottir, Gudny;  Yang, Xia;  Orth, Anthony P.;  Jennings, Lori L.;  Gudnason, Vilmundur
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Chiral Majorana fermion modes in a quantum anomalous Hall insulator-superconductor structure 期刊论文
SCIENCE, 2017, 357 (6348) : 294-299
作者:  He, Qing Lin;  Pan, Lei;  Stern, Alexander L.;  Burks, Edward C.;  Che, Xiaoyu;  Yin, Gen;  Wang, Jing;  Lian, Biao;  Zhou, Quan;  Choi, Eun Sang;  Murata, Koichi;  Kou, Xufeng;  Chen, Zhijie;  Nie, Tianxiao;  Shao, Qiming;  Fan, Yabin;  Zhang, Shou-Cheng;  Liu, Kai;  Xia, Jing;  Wang, Kang L.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27