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Massive and rapid predominantly volcanic CO2 emission during the end-Permian mass extinction 期刊论文
Proceedings of the National Academy of Science, 2021
作者:  Ying Cui;  Mingsong Li;  Elsbeth E. van Soelen;  Francien Peterse;  Wolfram M. Kürschner
收藏  |  浏览/下载:16/0  |  提交时间:2021/09/14
Atmospheric water budget associated with a local heavy precipitation event near the Central Urban Area of Beijing Metropolitan Region 期刊论文
Atmospheric Research, 2021
作者:  Tingting Lu, Xiaopeng Cui, Qiangli Zou, Huiqi Li
收藏  |  浏览/下载:8/0  |  提交时间:2021/04/06
Seasonal drought events in tropical East Asia over the last 60,000 y 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Jianping Zhang;  Houyuan Lu;  Jiwei Jia;  Caiming Shen;  Shuyun Wang;  Guoqiang Chu;  Luo Wang;  Anning Cui;  Jiaqi Liu;  Naiqin Wu;  Fengjiang Li
收藏  |  浏览/下载:8/0  |  提交时间:2020/11/30
Diurnal and seasonal variations in water-soluble inorganic ions and nitrate dual isotopes of PM2.5: Implications for source apportionment and formation processes of urban aerosol nitrate 期刊论文
Atmospheric Research, 2020
作者:  Qinkai Li, Xiao-Dong Li, Zhou Yang, Gaoyang Cui, Shiyuan Ding
收藏  |  浏览/下载:8/0  |  提交时间:2020/08/18
Recent anthropogenic curtailing of Yellow River runoff and sediment load is unprecedented over the past 500 y 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Yu Liu;  Huiming Song;  Zhisheng An;  Changfeng Sun;  Valerie Trouet;  Qiufang Cai;  Ruoshi Liu;  Steven W. Leavitt;  Yi Song;  Qiang Li;  Congxi Fang;  Weijian Zhou;  Yinke Yang;  Zhao Jin;  Yunqiang Wang;  Junyan Sun;  Xingmin Mu;  Ying Lei;  Lu Wang;  Xuxiang Li;  Meng Ren;  Linlin Cui;  Xueli Zeng
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/09
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10414-10421
作者:  Chen, Song-Can;  Sun, Guo-Xin;  Yan, Yu;  Konstantinidis, Konstantinos T.;  Zhang, Si-Yu;  Deng, Ye;  Li, Xiao-Min;  Cui, Hui-Ling;  Musat, Florin;  Popp, Denny;  Rosen, Barry P.;  Zhu, Yong-Guan
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13
arsenic  detoxification  evolution  oxygen  biogeochemistry  
Accurate compound-specific C-14 dating of archaeological pottery vessels 期刊论文
NATURE, 2020, 580 (7804) : 506-+
作者:  Yin, Yafei;  Lu, J. Yuyang;  Zhang, Xuechun;  Shao, Wen;  Xu, Yanhui;  Li, Pan;  Hong, Yantao;  Cui, Li;  Shan, Ge;  Tian, Bin;  Zhang, Qiangfeng Cliff;  Shen, Xiaohua
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/13

Pottery is one of the most commonly recovered artefacts from archaeological sites. Despite more than a century of relative dating based on typology and seriation(1), accurate dating of pottery using the radiocarbon dating method has proven extremely challenging owing to the limited survival of organic temper and unreliability of visible residues(2-4). Here we report a method to directly date archaeological pottery based on accelerator mass spectrometry analysis of C-14 in absorbed food residues using palmitic (C-16:0) and stearic (C-18:0) fatty acids purified by preparative gas chromatography(5-8). We present accurate compound-specific radiocarbon determinations of lipids extracted from pottery vessels, which were rigorously evaluated by comparison with dendrochronological dates(9,10) and inclusion in site and regional chronologies that contained previously determined radiocarbon dates on other materials(11-15). Notably, the compound-specific dates from each of the C-16:0 and C-18:0 fatty acids in pottery vessels provide an internal quality control of the results(6) and are entirely compatible with dates for other commonly dated materials. Accurate radiocarbon dating of pottery vessels can reveal: (1) the period of use of pottery  (2) the antiquity of organic residues, including when specific foodstuffs were exploited  (3) the chronology of sites in the absence of traditionally datable materials  and (4) direct verification of pottery typochronologies. Here we used the method to date the exploitation of dairy and carcass products in Neolithic vessels from Britain, Anatolia, central and western Europe, and Saharan Africa.


Using lipid residues absorbed in potsherds, the ages of pottery from various archaeological sites are determined and validated using sites for which the dates are well known from other methods.