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Convergent genes shape budding yeast pericentromeres 期刊论文
NATURE, 2020
作者:  Yin, Xuefan;  Jin, Jicheng;  Soljacic, Marin;  Peng, Chao;  Zhen, Bo
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

The three-dimensional structure of pericentromeres in budding yeast is defined by convergent genes, which mark pericentromere borders and trap cohesin complexes loaded at centromeres, generating an architecture that allows correct chromosome segregation.


The three-dimensional architecture of the genome governs its maintenance, expression and transmission. The cohesin protein complex organizes the genome by topologically linking distant loci, and is highly enriched in specialized chromosomal domains surrounding centromeres, called pericentromeres(1-6). Here we report the three-dimensional structure of pericentromeres in budding yeast (Saccharomyces cerevisiae) and establish the relationship between genome organization and function. We find that convergent genes mark pericentromere borders and, together with core centromeres, define their structure and function by positioning cohesin. Centromeres load cohesin, and convergent genes at pericentromere borders trap it. Each side of the pericentromere is organized into a looped conformation, with border convergent genes at the base. Microtubule attachment extends a single pericentromere loop, size-limited by convergent genes at its borders. Reorienting genes at borders into a tandem configuration repositions cohesin, enlarges the pericentromere and impairs chromosome biorientation during mitosis. Thus, the linear arrangement of transcriptional units together with targeted cohesin loading shapes pericentromeres into a structure that is competent for chromosome segregation. Our results reveal the architecture of the chromosomal region within which kinetochores are embedded, as well as the restructuring caused by microtubule attachment. Furthermore, we establish a direct, causal relationship between the three-dimensional genome organization of a specific chromosomal domain and cellular function.


  
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tang, Bai-Lu;  Yang, Jie;  Chen, Xiu-Lan;  Wang, Peng;  Zhao, Hui-Lin;  Su, Hai-Nan;  Li, Chun-Yang;  Yu, Yang;  Zhong, Shuai;  Wang, Lei;  Lidbury, Ian;  Ding, Haitao;  Wang, Min;  McMinn, Andrew;  Zhang, Xi-Ying;  Chen, Yin;  Zhang, Yu-Zhong
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (38) : 9592-9597
作者:  Burnett, Richard;  Chen, Hong;  Szyszkowicz, Mieczyslaw;  Fann, Neal;  Hubbell, Bryan;  Pope, C. Arden;  Apte, Joshua S.;  Brauer, Michael;  Cohen, Aaron;  Weichenthal, Scott;  Coggins, Jay;  Di, Qian;  Brunekreef, Bert;  Frostad, Joseph;  Lim, Stephen S.;  Kan, Haidong;  Walker, Katherine D.;  Thurston, George D.;  Hayes, Richard B.;  Lim, Chris C.;  Turner, Michelle C.;  Jerrett, Michael;  Krewski, Daniel;  Gapstur, Susan M.;  Diver, W. Ryan;  Ostro, Bart;  Goldberg, Debbie;  Crouse, Daniel L.;  Martin, Randall V.;  Peters, Paul;  Pinault, Lauren;  Tjepkema, Michael;  van Donkelaar, Aaron;  Villeneuve, Paul J.;  Miller, Anthony B.;  Yin, Peng;  Zhou, Maigeng;  Wang, Lijun;  Janssen, Nicole A. H.;  Marra, Marten;  Atkinson, Richard W.;  Tsang, Hilda;  Thuan Quoc Thach;  Cannon, John B.;  Allen, Ryan T.;  Hart, Jaime E.;  Laden, Francine;  Cesaroni, Giulia;  Forastiere, Francesco;  Weinmayr, Gudrun;  Jaensch, Andrea;  Nagel, Gabriele;  Concin, Hans;  Spadaro, Joseph V.
收藏  |  浏览/下载:53/0  |  提交时间:2019/11/27
mortality  exposure  risk  concentration  fine particulate matter  
Single-stranded DNA and RNA origami 期刊论文
SCIENCE, 2017, 358 (6369)
作者:  Han, Dongran;  Qi, Xiaodong;  Myhrvold, Cameron;  Wang, Bei;  Dai, Mingjie;  Jiang, Shuoxing;  Bates, Maxwell;  Liu, Yan;  An, Byoungkwon;  Zhang, Fei;  Yan, Hao;  Yin, Peng
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Ground-to-satellite quantum teleportation 期刊论文
NATURE, 2017, 549 (7670) : 70-+
作者:  Ren, Ji-Gang;  Xu, Ping;  Yong, Hai-Lin;  Zhang, Liang;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Yang, Meng;  Li, Li;  Yang, Kui-Xing;  Han, Xuan;  Yao, Yong-Qiang;  Li, Ji;  Wu, Hai-Yan;  Wan, Song;  Liu, Lei;  Liu, Ding-Quan;  Kuang, Yao-Wu;  He, Zhi-Ping;  Shang, Peng;  Guo, Cheng;  Zheng, Ru-Hua;  Tian, Kai;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Lu, Chao-Yang;  Shu, Rong;  Chen, Yu-Ao;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27