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DOI | 10.1126/science.aao2648 |
Single-stranded DNA and RNA origami | |
Han, Dongran1,2; Qi, Xiaodong3,4; Myhrvold, Cameron1,2; Wang, Bei2,5; Dai, Mingjie1,2; Jiang, Shuoxing3,4; Bates, Maxwell6; Liu, Yan3,4; An, Byoungkwon6; Zhang, Fei3,4; Yan, Hao3,4; Yin, Peng1,2 | |
2017-12-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6369 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Self-folding of an information-carrying polymer into a defined structure is foundational to biology and offers attractive potential as a synthetic strategy. Although multicomponent self-assembly has produced complex synthetic nanostructures, unimolecular folding has seen limited progress. We describe a framework to design and synthesize a single DNA or RNA strand to self-fold into a complex yet unknotted structure that approximates an arbitrary user-prescribed shape. We experimentally construct diverse multikilobase single-stranded structures, including a similar to 10,000-nucleotide (nt) DNA structure and a similar to 6000-nt RNA structure. We demonstrate facile replication of the strand in vitro and in living cells. The work here thus establishes unimolecular folding as a general strategy for constructing complex and replicable nucleic acid nanostructures, and expands the design space and material scalability for bottom-up nanotechnology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417918500033 |
WOS关键词 | CROSSOVER DNA ; FOLDING DNA ; NANOSTRUCTURES ; DESIGN ; ASSEMBLIES ; MOLECULE ; SHAPES ; KNOTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197559 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA; 2.Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA; 3.Biodesign Ctr Mol Design & Biomimet Biodesign Ins, Tempe, AZ 85287 USA; 4.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA; 5.Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China; 6.BioNlano Res Grp, Autodesk Life Sci, Pier 9, San Francisco, CA 94111 USA |
推荐引用方式 GB/T 7714 | Han, Dongran,Qi, Xiaodong,Myhrvold, Cameron,et al. Single-stranded DNA and RNA origami[J]. SCIENCE,2017,358(6369). |
APA | Han, Dongran.,Qi, Xiaodong.,Myhrvold, Cameron.,Wang, Bei.,Dai, Mingjie.,...&Yin, Peng.(2017).Single-stranded DNA and RNA origami.SCIENCE,358(6369). |
MLA | Han, Dongran,et al."Single-stranded DNA and RNA origami".SCIENCE 358.6369(2017). |
条目包含的文件 | 条目无相关文件。 |
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