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Assessments of the factors controlling latent heat flux and the coupling degree between an alpine wetland and the atmosphere on the Qinghai-Tibetan Plateau in summer 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Chen, Jinlei;  Wen, Jun;  Kang, Shichang;  Meng, Xianhong;  Tian, Hui;  Ma, Xin;  Yuan, Yuan
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Wetlands  Latent heat  Coupling  Control factor  CLM  
Coherent Interannual Variations of Springtime Surface Temperature and Temperature Extremes Between Central-Northern Europe and Northeast Asia 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (11)
作者:  Chen, Shangfeng;  Wu, Renguang;  Chen, Wen;  Yao, Shuailei;  Yu, Bin
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
spring temperature  coherent variation  central-northern Europe and Northeast Asia  atmospheric teleconnection  synoptic-scale eddy forcing  North Atlantic SST forcing  
Marine organic matter in the remote environment of the Cape Verde islands - an introduction and overview to the MarParCloud campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 6921-6951
作者:  van Pinxteren, Manuela;  Fomba, Khanneh Wadinga;  Triesch, Nadja;  Stolle, Christian;  Wurl, Oliver;  Bahlmann, Enno;  Gong, Xianda;  Voigtlaender, Jens;  Wex, Heike;  Robinson, Tiera-Brandy;  Barthel, Stefan;  Zeppenfeld, Sebastian;  Hoffmann, Erik Hans;  Roveretto, Marie;  Li, Chunlin;  Grosselin, Benoit;  Daele, Veronique;  Senf, Fabian;  van Pinxteren, Dominik;  Manzi, Malena;  Zabalegui, Nicolas;  Frka, Sanja;  Gasparovic, Blazenka;  Pereira, Ryan;  Li, Tao;  Wen, Liang;  Li, Jiarong;  Zhu, Chao;  Chen, Hui;  Chen, Jianmin;  Fiedler, Bjoern;  Von Tuempling, Wolf;  Read, Katie Alana;  Punjabi, Shalini;  Lewis, Alastair Charles;  Hopkins, James Roland;  Carpenter, Lucy Jane;  Peeken, Ilka;  Rixen, Tim;  Schulz-Bull, Detlef;  Monge, Maria Eugenia;  Mellouki, Abdelwahid;  George, Christian;  Stratmann, Frank;  Herrmann, Hartmut
收藏  |  浏览/下载:23/0  |  提交时间:2020/08/18
Global Model of Whistler Mode Chorus in the Near-Equatorial Region (|lambda(m)|< 18 degrees) 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Meredith, Nigel P.;  Horne, Richard B.;  Shen, Xiao-Chen;  Li, Wen;  Bortnik, Jacob
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/25
whistler mode chorus  wave-particle interactions  radiation belts  
Sustainable production of value-added carbon nanomaterials from biomass pyrolysis 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Zhang, Shun;  Jiang, Shun-Feng;  Huang, Bao-Cheng;  Shen, Xian-Cheng;  Chen, Wen-Jing;  Zhou, Tian-Pei;  Cheng, Hui-Yuan;  Cheng, Bin-Hai;  Wu, Chang-Zheng;  Li, Wen-Wei;  Jiang, Hong;  Yu, Han-Qing
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/20
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
Contrasting frontal and warm-sector heavy rainfalls over South China during the early-summer rainy season 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Wu, Naigeng;  Ding, Xi;  Wen, Zhiping;  Chen, Guixing;  Meng, Zhiyong;  Lin, Liangxun;  Min, Jinzhong
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Warm-sector heavy rainfall  Frontal heavy rainfall  Monsoon  Land-sea breeze  Diurnal variation  Early-summer rainy season  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Insight Into Major Active Faults in Central Myanmar and the Related Geodynamic Sources 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (8)
作者:  Mon, Chit Thet;  Gong, Xuan;  Wen, Yun;  Jiang, Mingming;  Chen, Qi-Fu;  Zhang, Miao;  Hou, Guangbing;  Thant, Myo;  Sein, Kyaing;  He, Yumei
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
earthquake relocation  Myanmar crustal seismicity  Kabaw Fault Zone  Sagaing Fault  Central Basin  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.