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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA 期刊论文
NATURE, 2020, 583 (7814) : 139-+
作者:  Muniz, Juan A.;  Barberena, Diego;  Lewis-Swan, Robert J.;  Young, Dylan J.;  Cline, Julia R. K.;  Rey, Ana Maria;  Thompson, James K.
收藏  |  浏览/下载：22/0  |  提交时间：2020/07/03

MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At present, the major parameter that can explain the selection of the target mRNA and the efficiency of translation repression is the base pairing between the '  seed'  region of the miRNA and its counterpart mRNA(1). Here we use R-1 rho relaxation-dispersion nuclear magnetic resonance(2) and molecular simulations(3) to reveal a dynamic switch-based on the rearrangement of a single base pair in the miRNA-mRNA duplex-that elongates a weak five-base-pair seed to a complete seven-base-pair seed. This switch also causes coaxial stacking of the seed and supplementary helix fitting into human Argonaute 2 protein (Ago2), reminiscent of an active state in prokaryotic Ago(4,5). Stabilizing this transient state leads to enhanced repression of the target mRNA in cells, revealing the importance of this miRNA-mRNA structure. Our observations tie together previous findings regarding the stepwise miRNA targeting process from an initial '  screening'  state to an '  active'  state, and unveil the role of the RNA duplex beyond the seed in Ago2.


Repression of a messenger RNA by a cognate microRNA depends not only on complementary base pairing, but also on the rearrangement of a single base pair, producing a conformation that fits better within the human Ago2 protein.


  
Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Amman, Brian R.;  Bird, Brian H.;  Bakarr, Ibrahim A.;  Bangura, James;  Schuh, Amy J.;  Johnny, Jonathan;  Sealy, Tara K.;  Conteh, Immah;  Koroma, Alusine H.;  Foday, Ibrahim;  Amara, Emmanuel;  Bangura, Abdulai A.;  Gbakima, Aiah A.;  Tremeau-Bravard, Alexandre;  Belaganahalli, Manjunatha;  Dhanota, Jasjeet;  Chow, Andrew;  Ontiveros, Victoria;  Gibson, Alexandra;  Turay, Joseph;  Patel, Ketan;  Graziano, James;  Bangura, Camilla;  Kamanda, Emmanuel S.;  Osborne, Augustus;  Saidu, Emmanuel;  Musa, Jonathan;  Bangura, Doris;  Williams, Samuel Maxwell Tom;  Wadsworth, Richard;  Turay, Mohamed;  Edwin, Lavalie;  Mereweather-Thompson, Vanessa;  Kargbo, Dickson;  Bairoh, Fatmata V.;  Kanu, Marilyn;  Robert, Willie;  Lungai, Victor;  Wadoum, Raoul Emeric Guetiya;  Coomber, Moinya;  Kanu, Osman;  Jambai, Amara;  Kamara, Sorie M.;  Taboy, Celine H.;  Singh, Tushar;  Mazet, Jonna A. K.;  Nichol, Stuart T.;  Goldstein, Tracey;  Towner, Jonathan S.;  Lebbie, Aiah
收藏  |  浏览/下载：10/0  |  提交时间：2020/05/13
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes 期刊论文
NATURE, 2019, 571 (7763) : 72-+
作者:  Johnson, Eachan O.;  LaVerriere, Emily;  Office, Emma;  Stanley, Mary;  Meyer, Elisabeth;  Kawate, Tomohiko;  Gomez, James E.;  Audette, Rebecca E.;  Bandyopadhyay, Nirmalya;  Betancourt, Natalia;  Delano, Kayla;  Da Silva, Israel;  Davis, Joshua;  Gallo, Christina;  Gardner, Michelle;  Golas, Aaron J.;  Guinn, Kristine M.;  Kennedy, Sofia;  Korn, Rebecca;  McConnell, Jennifer A.;  Moss, Caitlin E.;  Murphy, Kenan C.;  Nietupski, Raymond M.;  Papavinasasundaram, Kadamba G.;  Pinkham, Jessica T.;  Pino, Paula A.;  Proulx, Megan K.;  Ruecker, Nadine;  Song, Naomi;  Thompson, Matthew;  Trujillo, Carolina;  Wakabayashi, Shoko;  Wallach, Joshua B.;  Watson, Christopher;  Ioerger, Thomas R.;  Lander, Eric S.;  Hubbard, Brian K.;  Serrano-Wu, Michael H.;  Ehrt, Sabine;  Fitzgerald, Michael;  Rubin, Eric J.;  Sassetti, Christopher M.;  Schnappinger, Dirk;  Hung, Deborah T.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Alternatives to genetic affinity as a context for within-species response to climate 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (10) : 787-+
作者:  Smith, Adam B.;  Beever, Erik A.;  Kessler, Aimee E.;  Johnston, Aaron N.;  Ray, Chris;  Epps, Clinton W.;  Lanier, Hayley C.;  Klinger, Rob C.;  Rodhouse, Thomas J.;  Varner, Johanna;  Perrine, John D.;  Seglund, Amy;  Hall, L. Embere;  Galbreath, Kurt;  MacGlover, Chris;  Billman, Peter;  Blatz, Gretchen;  Brewer, Jason;  Vardaro, Jessica Castillo;  Chalfoun, Anna D.;  Collins, Gail;  Craighead, April;  Curlis, Chris;  Daly, Christopher;  Doak, Daniel F.;  East, Mitch;  Edwards, Mark;  Erb, Liesl;  Ernest, Kristina A.;  Fauver, Brian;  Foresman, Kerry R.;  Goehring, Ken;  Hagar, Joan;  Hayes, Charles L.;  Henry, Philippe;  Hersey, Kimberly;  Hilty, Shannon L.;  Jacobson, Jim;  Jeffress, Mackenzie R.;  Manning, Tom;  Masching, Amy;  Maxell, Bryce;  McCollough, Rayo;  McFarland, Corrie;  Miskow, Eric;  Morelli, Toni Lyn;  Moyer-Horner, Lucas;  Mueller, Megan;  Nugent, Martin;  Pratt, Beth;  Rasmussen-Flores, Mary;  Rickman, Tom H.;  Robison, Hillary;  Rodriguez, Arthur;  Rowe, Karen;  Rowe, Kevin;  Russello, Michael A.;  Saab, Vicki;  Schmidt, Angie;  Stewart, Joseph A. E.;  Stuart, James N.;  Svancara, Leona K.;  Thompson, Will;  Timmins, Julie;  Treinish, Gregg;  Waterhouse, Matthew D.;  Westover, Marie L.;  Wilkening, Jennifer;  Yandow, Leah
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Archaeological assessment reveals Earth's early transformation through land use 期刊论文
SCIENCE, 2019, 365 (6456) : 897-+
作者:  Stephens, Lucas;  Fuller, Dorian;  Boivin, Nicole;  Rick, Torben;  Gauthier, Nicolas;  Kay, Andrea;  Marwick, Ben;  Armstrong, Chelsey Geralda Denise;  Barton, C. Michael;  Denham, Tim;  Douglass, Kristina;  Driver, Jonathan;  Janz, Lisa;  Roberts, Patrick;  Rogers, J. Daniel;  Thakar, Heather;  Altaweel, Mark;  Johnson, Amber L.;  Sampietro Vattuone, Maria Marta;  Aldenderfer, Mark;  Archila, Sonia;  Artioli, Gilberto;  Bale, Martin T.;  Beach, Timothy;  Borrell, Ferran;  Braje, Todd;  Buckland, Philip I.;  Jimenez Cano, Nayeli Guadalupe;  Capriles, Jose M.;  Diez Castillo, Agustin;  Cilingiroglu, Ciler;  Cleary, Michelle Negus;  Conolly, James;  Coutros, Peter R.;  Covey, R. Alan;  Cremaschi, Mauro;  Crowther, Alison;  Der, Lindsay;  di Lernia, Savino;  Doershuk, John F.;  Doolittle, William E.;  Edwards, Kevin J.;  Erlandson, Jon M.;  Evans, Damian;  Fairbairn, Andrew;  Faulkner, Patrick;  Feinman, Gary;  Fernandes, Ricardo;  Fitzpatrick, Scott M.;  Fyfe, Ralph;  Garcea, Elena;  Goldstein, Steve;  Goodman, Reed Charles;  Guedes, Jade Dalpoim;  Herrmann, Jason;  Hiscock, Peter;  Hommel, Peter;  Horsburgh, K. Ann;  Hritz, Carrie;  Ives, John W.;  Junno, Aripekka;  Kahn, Jennifer G.;  Kaufman, Brett;  Kearns, Catherine;  Kidder, Tristram R.;  Lanoe, Francois;  Lawrence, Dan;  Lee, Gyoung-Ah;  Levin, Maureece J.;  Lindskoug, Henrik B.;  Antonio Lopez-Saez, Jose;  Macrae, Scott;  Marchant, Rob;  Marston, John M.;  McClure, Sarah;  Mccoy, Mark D.;  Miller, Alicia Ventresca;  Morrison, Michael;  Matuzeviciute, Giedre Motuzaite;  Mueller, Johannes;  Nayak, Ayushi;  Noerwidi, Sofwan;  Peres, Tanya M.;  Peterson, Christian E.;  Proctor, Lucas;  Randall, Asa R.;  Renette, Steve;  Schug, Gwen Robbins;  Ryzewski, Krysta;  Saini, Rakesh;  Scheinsohn, Vivian;  Schmidt, Peter;  Sebillaud, Pauline;  Seitsonen, Oula;  Simpson, Ian A.;  Soltysiak, Arkadiusz;  Speakman, Robert J.;  Spengler, Robert N.;  Steffen, Martina L.;  Storozum, Michael J.;  Strickland, Keir M.;  Thompson, Jessica;  Thurston, T. L.;  Ulm, Sean;  Ustunkaya, M. Cemre;  Welker, Martin H.;  West, Catherine;  Williams, Patrick Ryan;  Wright, David K.;  Wright, Nathan;  Zahir, Muhammad;  Zerboni, Andrea;  Beaudoin, Ella;  Garcia, Santiago Munevar;  Powell, Jeremy;  Thornton, Alexa;  Kaplan, Jed O.;  Gaillard, Marie-Jose;  Goldewijk, Kees Klein;  Ellis, Erle
收藏  |  浏览/下载：56/0  |  提交时间：2019/11/27
Atmospheric Acetaldehyde: Importance of Air-Sea Exchange and a Missing Source in the Remote Troposphere 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (10) : 5601-5613
作者:  Wang, Siyuan;  Hornbrook, Rebecca S.;  Hills, Alan;  Emmons, Louisa K.;  Tilmes, Simone;  Lamarque, Jean-Francois;  Jimenez, Jose L.;  Campuzano-Jost, Pedro;  Nault, Enjamin A.;  Crounse, John D.;  Wennberg, Paul O.;  Kim, Michelle;  Allen, Hannah;  Ryerson, Thomas B.;  Thompson, Chelsea R.;  Peischl, Jeff;  Moore, Fred;  Nance, David;  Hall, Brad;  Elkins, James;  Tanner, David;  Huey, L. Gregory;  Hall, Samuel R.;  Ullmann, Kirk;  Orlando, John J.;  Tyndall, Geoff S.;  Flocke, Frank M.;  Ray, Eric;  Hanisco, Thomas F.;  Wolfe, Glenn M.;  St Clair, Jason;  Commane, Roisin;  Daube, Bruce;  Barletta, Barbara;  Blake, Donald R.;  Weinzierl, Bernadett;  Dollner, Maximilian;  Conley, Andrew;  Vitt, Francis;  Wofsy, Steven C.;  Riemer, Daniel D.;  Apel, Eric C.
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/26
Cavity-mediated collective spin-exchange interactions in a strontium superradiant laser 期刊论文
SCIENCE, 2018, 361 (6399) : 259-262
作者:  Norcia, Matthew A.;  Lewis-Swan, Robert J.;  Cline, Julia R. K.;  Zhu, Bihui;  Rey, Ana M.;  Thompson, James K.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Whole-genome landscapes of major melanoma subtypes 期刊论文
NATURE, 2017, 545 (7653) : 175-180
作者:  Hayward, Nicholas K.;  Wilmott, James S.;  Waddell, Nicola;  Johansson, Peter A.;  Field, Matthew A.;  Nones, Katia;  Patch, Ann-Marie;  Kakavand, Hojabr;  Alexandrov, Ludmil B.;  Burke, Hazel;  Jakrot, Valerie;  Kazakoff, Stephen;  Holmes, Oliver;  Leonard, Conrad;  Sabarinathan, Radhakrishnan;  Mularoni, Loris;  Wood, Scott;  Xu, Qinying;  Waddell, Nick;  Tembe, Varsha;  Pupo, Gulietta M.;  De Paoli-Iseppi, Ricardo;  Vilain, Ricardo E.;  Shang, Ping;  Lau, Loretta M. S.;  Dagg, Rebecca A.;  Schramm, Sarah-Jane;  Pritchard, Antonia;  Dutton-Regester, Ken;  Newell, Felicity;  Fitzgerald, Anna;  Shang, Catherine A.;  Grimmond, Sean M.;  Pickett, Hilda A.;  Yang, Jean Y.;  Stretch, Jonathan R.;  Behren, Andreas;  Kefford, Richard F.;  Hersey, Peter;  Long, Georgina V.;  Cebon, Jonathan;  Shackleton, Mark;  Spillane, Andrew J.;  Saw, Robyn P. M.;  Lopez-Bigas, Nuria;  Pearson, John V.;  Thompson, John F.;  Scolyer, Richard A.;  Mann, Graham J.
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09