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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Validity of managing peatlands with fire (vol 82, pg 237, 2019) 期刊论文
NATURE GEOSCIENCE, 2020, 13 (1) : 94-94
作者:  Marrs, R. H.;  Marsland, E. -L;  Lingard, R.;  Appleby, P. G.;  Piliposyan, G. T.;  Rose, R. J.;  O&;  39;  Reilly, J.;  Milligan, G.;  Allen, K. A.;  Alday, J. G.;  Santana, V.;  Lee, H.;  Halsall, K.;  Chiverrell, R. C.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Establishment and heteroblasty of Acacia koa in canopy gaps 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 453
作者:  Rose, Kyle M. E.;  Friday, James B.;  Jacobs, Douglass F.
收藏  |  浏览/下载：6/0  |  提交时间：2020/02/17
Gap silviculture  Growth-survival trade-off  Heteroblasty  Irradiance  Koa  Rust  Shade tolerance  
"Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe (vol 116, pg17231, 2019) 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (25) : 14610-14611
作者:  Frantz, Laurent A. F.;  Haile, James;  Lin, Audrey T.;  Scheu, Amelie;  Geoerg, Christina;  Benecke, Norbert;  Alexander, Michelle;  Linderholm, Anna;  Mullin, Victoria E.;  Daly, Kevin G.;  Battista, Vincent M.;  Price, Max;  Gron, Kurt J.;  Alexandri, Panoraia;  Arbogast, Rose-Marie;  Arbuckle, Benjamin;  Balasescu, Adrian;  Barnett, Ross;  Bartosiewicz, Laszlo;  Baryshnikov, Gennady;  Bonsall, Clive;  Boric, Dian;  Boroneant, Adina;  Bulatovic, Jelena;  Cakirlar, Canan;  Carreterow, Jose-Miguel;  Chapman, John;  Church, Mike;  Crooijmans, Richard;  De Cupere, Bea;  Detry, Cleia;  Dimitrijevic, Vesna;  Dumitrascu, Valentin;  du Plessis, Louis;  Edwards, Ceiridwen J.;  Erek, Cevdet Merih;  Erim-Ozdogan, Ash;  Ervynck, Anton;  Fulgione, Domenico;  Gligor, Mihai;  Gotherstrom, Anders;  Gourichon, Lionel;  Groenen, Martien A. M.;  Helmer, Daniel;  Hongo, Hitomi;  Horwitz, Liora K.;  Irving-Pease, Evan K.;  Lebrasseur, Ophelie;  Lesur, Josephine;  Malone, Caroline;  Manaseryan, Ninna;  Marciniak, Arkadiusz;  Martlew, Holley;  Mashkour, Marjan;  Matthews, Roger;  Matuzeviciute, Giedre Motuzaite;  Maziar, Sepideh;  Meijaard, Erik;  McGovern, Tom;  Megens, Hendrik-Jan;  Miller, Rebecca;  Mohaseb, Azadeh Fatemeh;  Orschiedt, Jorg;  Orton, David;  Papathanasiou, Anastasia;  Pearson, Mike Parker;  Pinhasi, Ron;  Radmanovic, Darko;  Ricaut, Francois-Xavier;  Richards, Mike;  Sabin, Richard;  Sarti, Lucia;  Schier, Wolfram;  Sheikhi, Shiva;  Stephan, Elisabeth;  Stewart, John R.;  Stoddart, Simon;  Tagliacozzo, Antonio;  Tasic, Nenad;  Trantalidou, Katerina;  Tresset, Anne;  Valdiosera, Cristina;  van den Hurk, Youri;  Van Poucke, Sophie;  Vigne, Jean-Denis;  Yanevich, Alexander;  Zeeb-Lanz, Andrea;  Triantafyllidis, Alexandros;  Gilbert, M. Thomas P.;  Schibler, Jorg;  Rowley-Conwy, Peter;  Zeder, Melinda;  Peters, Joris;  Cucchi, Thomas;  Bradley, Daniel G.;  Dobney, Keith;  Burger, Joachim;  Evin, Allowen;  Girdland-Flink, Linus;  Larson, Greger
收藏  |  浏览/下载：18/0  |  提交时间：2020/02/17
Ozone depletion, ultraviolet radiation, climate change and prospects for a sustainable future 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (7) : 569-579
作者:  Barnes, Paul W.;  Williamson, Craig E.;  Lucas, Robyn M.;  Robinson, Sharon A.;  Madronich, Sasha;  Paul, Nigel D.;  Bornman, Janet F.;  Bais, Alkiviadis F.;  Sulzberger, Barbara;  Wilson, Stephen R.;  Andrady, Anthony L.;  McKenzie, Richard L.;  Neale, Patrick J.;  Austin, Amy T.;  Bernhard, Germar H.;  Solomon, Keith R.;  Neale, Rachel E.;  Young, Paul J.;  Norval, Mary;  Rhodes, Lesley E.;  Hylander, Samuel;  Rose, Kevin C.;  Longstreth, Janice;  Aucamp, Pieter J.;  Ballare, Carlos L.;  Cory, Rose M.;  Flint, Stephan D.;  de Gruijl, Frank R.;  Haeder, Donat-P;  Heikkila, Anu M.;  Jansen, Marcel A. K.;  Pandey, Krishna K.;  Robson, T. Matthew;  Sinclair, Craig A.;  Wangberg, Sten-Ake;  Worrest, Robert C.;  Yazar, Seyhan;  Young, Antony R.;  Zepp, Richard G.
收藏  |  浏览/下载：16/0  |  提交时间：2020/08/19
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Ashraf, Shazia;  Kudo, Hiroki;  Rao, Jia;  Kikuchi, Atsuo;  Widmeier, Eugen;  Lawson, Jennifer A.;  Tan, Weizhen;  Hermle, Tobias;  Warejko, Jillian K.;  Shril, Shirlee;  Airik, Merlin;  Jobst-Schwan, Tilman;  Lovric, Svjetlana;  Braun, Daniela A.;  Gee, Heon Yung;  Schapiro, David;  Majmundar, Amar J.;  Sadowski, Carolin E.;  Pabst, Werner L.;  Daga, Ankana;  van der Ven, Amelie T.;  Schmidt, Johanna M.;  Low, Boon Chuan;  Gupta, Anjali Bansal;  Tripathi, Brajendra K.;  Wong, Jenny;  Campbell, Kirk;  Metcalfe, Kay;  Schanze, Denny;  Niihori, Tetsuya;  Kaito, Hiroshi;  Nozu, Kandai;  Tsukaguchi, Hiroyasu;  Tanaka, Ryojiro;  Hamahira, Kiyoshi;  Kobayashi, Yasuko;  Takizawa, Takumi;  Funayama, Ryo;  Nakayama, Keiko;  Aoki, Yoko;  Kumagai, Naonori;  Iijima, Kazumoto;  Fehrenbach, Henry;  Kari, Jameela A.;  El Desoky, Sherif;  Jalalah, Sawsan;  Bogdanovic, Radovan;  Stajic, Natasa;  Zappel, Hildegard;  Rakhmetova, Assel;  Wassmer, Sharon-Rose;  Jungraithmayr, Therese;  Strehlau, Juergen;  Kumar, Aravind Selvin;  Bagga, Arvind;  Soliman, Neveen A.;  Mane, Shrikant M.;  Kaufman, Lewis;  Lowy, Douglas R.;  Jairajpuri, Mohamad A.;  Lifton, Richard P.;  Pei, York;  Zenker, Martin;  Kure, Shigeo;  Hildebrandt, Friedhelm
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt object 期刊论文
SCIENCE, 2019, 364 (6441) : 649-+
作者:  Stern, S. A.;  Weaver, H. A.;  Spencer, J. R.;  Olkin, C. B.;  Gladstone, G. R.;  Grundy, W. M.;  Moore, J. M.;  Cruikshank, D. P.;  Elliott, H. A.;  McKinnon, W. B.;  Parker, J. Wm.;  Verbiscer, A. J.;  Young, L. A.;  Aguilar, D. A.;  Albers, J. M.;  Andert, T.;  Andrews, J. P.;  Bagenal, F.;  Banks, M. E.;  Bauer, B. A.;  Bauman, J. A.;  Bechtold, K. E.;  Beddingfield, C. B.;  Behrooz, N.;  Beisser, K. B.;  Benecchi, S. D.;  Bernardoni, E.;  Beyer, R. A.;  Bhaskaran, S.;  Bierson, C. J.;  Binzel, R. P.;  Birath, E. M.;  Bird, M. K.;  Boone, D. R.;  Bowman, A. F.;  Bray, V. J.;  Britt, D. T.;  Brown, L. E.;  Buckley, M. R.;  Buie, M. W.;  Buratti, B. J.;  Burke, L. M.;  Bushman, S. S.;  Careich, B.;  Chaikin, A. L.;  Chavez, C. L.;  Cheng, A. F.;  Colwell, E. J.;  Conard, S. J.;  Conner, M. P.;  Conrad, C. A.;  Cook, J. C.;  Cooper, S. B.;  Custodio, O. S.;  Ore, C. M. Dalle;  Deboy, C. C.;  Dharmavaram, P.;  Dhingra, R. D.;  Dunn, G. F.;  Earle, A. M.;  Egan, A. F.;  Eisig, J.;  El-Maarry, M. R.;  Engelbrecht, C.;  Enke, B. L.;  Ercol, C. J.;  Fattig, E. D.;  Ferrell, C. L.;  Finley, T. J.;  Firer, J.;  Fischetti, J.;  Folkner, W. M.;  Fosbury, M. N.;  Fountain, G. H.;  Freeze, J. M.;  Gabasova, L.;  Glaze, L. S.;  Green, J. L.;  Griffith, G. A.;  Guo, Y.;  Hahn, M.;  Hals, D. W.;  Hamilton, D. P.;  Hamilton, S. A.;  Hanley, J. J.;  Harch, A.;  Harmon, K. A.;  Hart, H. M.;  Hayes, J.;  Hersman, C. B.;  Hill, M. E.;  Hill, T. A.;  Hofgartner, J. D.;  Holdridge, M. E.;  Horanyi, M.;  Hosadurga, A.;  Howard, A. D.;  Howett, C. J. A.;  Jaskulek, S. E.;  Jennings, D. E.;  Jensen, J. R.;  Jones, M. R.;  Kang, H. K.;  Katz, D. J.;  Kaufmann, D. E.;  Kavelaars, J. J.;  Keane, J. T.;  Keleher, G. P.;  Kinczyk, M.;  Kochte, M. C.;  Kolmnann, P.;  Krimigis, S. M.;  Kruizinga, G. L.;  Kusnierkiewicz, D. Y.;  Lahr, M. S.;  Lauer, T. R.;  Lawrence, G. B.;  Lee, J. E.;  Lessac-Chenen, E. J.;  Linscott, I. R.;  Lisse, C. M.;  Lunsford, A. W.;  Mages, D. M.;  Mallder, V. A.;  Martin, N. P.;  May, B. H.;  McComas, D. J.;  MeNutt, R. L., Jr.;  Mehoke, D. S.;  Mehoke, T. S.;  Nelson, D. S.;  Nguyen, H. D.;  Nunez, J. I.;  Ocampo, A. C.;  Owen, W. M.;  Oxton, G. K.;  Parker, A. H.;  Patzold, M.;  Pelgrift, J. Y.;  Pelletier, F. J.;  Pineau, J. P.;  Piquette, M. R.;  Porter, S. B.;  Protopapa, S.;  Quirico, E.;  Redfern, J. A.;  Regiec, A. L.;  Reitsema, H. J.;  Reuter, D. C.;  Richardson, D. C.;  Riedel, J. E.;  Ritterbush, M. A.;  Robbins, S. J.;  Rodgers, D. J.;  Rogers, G. D.;  Rose, D. M.;  Rosendal, P. E.;  Runyon, K. D.;  Ryschkewitsch, M. G.;  Saina, M. M.;  Salinas, M. J.;  Schenk, P. M.;  Scherrer, J. R.;  Schlei, W. R.;  Schmitt, B.;  Schultz, D. J.;  Schurr, D. C.;  Scipioni, F.;  Sepan, R. L.;  Shelton, R. G.;  Showalter, M. R.;  Simon, M.;  Singer, K. N.;  Stahlheber, E. W.;  Stanbridge, D. R.;  Stansberry, J. A.;  Steffi, A. J.;  Strobel, D. F.;  Stothoff, M. M.;  Stryk, T.;  Stuart, J. M.;  Summers, M. E.;  Tapley, M. B.;  Taylor, A.;  Taylor, H. W.;  Tedford, R. M.;  Throop, H. B.;  Turner, L. S.;  Umurhan, O. M.;  Van Eck, J.;  Velez, D.;  Versteeg, M. H.;  Vincent, M. A.;  Webbert, R. W.;  Weidner, S. E.;  Ii, G. E. Weigle;  Wendel, J. R.;  White, O. L.;  Whittenburg, K. E.;  Williams, B. G.;  Williams, K. E.;  Williams, S. P.;  Wimters, H. L.;  Zangari, A. M.;  Zurbuchen, T. H.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Research Weaving: Visualizing the Future of Research Synthesis 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (3) : 224-238
作者:  Nakagawa, Shinichi;  39;Dea, Rose E.
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/09
Significant Floodplain Soil Organic Carbon Storage Along a Large High-Latitude River and its Tributaries 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (4) : 2121-2129
作者:  Lininger, K. B.;  Wohl, E.;  Rose, J. R.;  Leisz, S. J.
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
boreal floodplains  organic carbon  fluvial geomorphology  permafrost landscapes  
Radiative Heating Rates Computed With Clouds Derived From Satellite-Based Passive and Active Sensors and their Effects on Generation of Available Potential Energy 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (3) : 1720-1740
作者:  Kato, Seiji;  Rose, Fred G.;  Ham, Seung Hee;  Rutan, David A.;  Radkevich, Alexander;  Caldwell, Thomas E.;  Sun-Mack, Sunny;  Miller, Walter F.;  Chen, Yan
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
heating rate  radiation  clouds  available potential energy