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Spatio-temporal variation of reference evapotranspiration in northwest China based on CORDEX-EA 期刊论文
ATMOSPHERIC RESEARCH, 2020, 238
作者:  Yang, Linshan;  Feng, Qi;  Adamowski, Jan F.;  Yin, Zhenliang;  Wen, Xiaohu;  Wu, Min;  Jia, Bing;  Hao, Qiang
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/18
CORDEX-EA  Reference evapotranspiration  Machine learning algorithm  Northwest China  
Contrasting frontal and warm-sector heavy rainfalls over South China during the early-summer rainy season 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Wu, Naigeng;  Ding, Xi;  Wen, Zhiping;  Chen, Guixing;  Meng, Zhiyong;  Lin, Liangxun;  Min, Jinzhong
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Warm-sector heavy rainfall  Frontal heavy rainfall  Monsoon  Land-sea breeze  Diurnal variation  Early-summer rainy season  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Hard or soft flood adaptation? Advantages of a hybrid strategy for Shanghai 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 61
作者:  Du, Shiqiang;  Scussolini, Paolo;  Ward, Philip J.;  Zhang, Min;  Wen, Jiahong;  Wang, Luyang;  Koks, Elco;  Diaz-Loaiza, Andres;  Gao, Jun;  Ke, Qian;  Aerts, Jeroen C. J. H.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
Climate change  Nonstationarity  Coastal flood  Risk management  Cost-benefit analysis  
Quasi-Biweekly Oscillation of the South Asian High and Its Role in Connecting the Indian and East Asian Summer Rainfalls 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Wei, Wei;  Zhang, Renhe;  Yang, Song;  Li, Wenhong;  Wen, Min
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
South Asian high  Indian summer monsoon  East Asian summer monsoon  intraseasonal variation  quasi-biweekly oscillation  monsoon rainfall  
Dynamic effect of the South Asian high on the interannual zonal extension of the western North Pacific subtropical high 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (14) : 5367-5379
作者:  Wei, Wei;  Zhang, Renhe;  Wen, Min;  Yang, Song;  Li, Wenhong
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
East Asian summer monsoon  relative vorticity  South Asian high  western North Pacific subtropical high  
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion 期刊论文
SCIENCE, 2019, 366 (6468) : 1013-+
作者:  Leone, Robert D.;  Zhao, Liang;  Englert, Judson M.;  Sun, Im-Meng;  Oh, Min-Hee;  Sun, Im-Hong;  Arwood, Matthew L.;  Bettencourt, Ian A.;  Patel, Chirag H.;  Wen, Jiayu;  Tam, Ada;  Blosser, Richard L.;  Prchalova, Eva;  Alt, Jesse;  Rais, Rana;  Slusher, Barbara S.;  Powell, Jonathan D.
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
Diagnostics of westward propagating East Asian monsoon low-pressure systems that reach the Indian monsoon region 期刊论文
CLIMATE DYNAMICS, 2019
作者:  Shi, Xiaohui;  Kiladis, George;  Wen, Min
收藏  |  浏览/下载:8/0  |  提交时间:2020/02/17
East Asian monsoon low pressure system  India monsoon region  Potential vorticity (PV)  PV budget  
The influence of wave trains in mid-high latitudes on persistent heavy rain during the first rainy season over South China 期刊论文
CLIMATE DYNAMICS, 2019, 53: 2949-2968
作者:  Miao, Rui;  Wen, Min;  Zhang, Renhe;  Li, Lun
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
First rainy season over South China  Persistent heavy rain  Wave train  Quasi-biweekly oscillation