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Amagmatic Subduction Produced by Mantle Serpentinization and Oceanic Crust Delamination 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Yang, Jianfeng;  Lu, Gang;  Liu, Tong;  Li, Yang;  Wang, Kun;  Wang, Xinxin;  Sun, Baolu;  Faccenda, Manuele;  Zhao, Liang
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
numerical modeling  arc gap  flux melting  subduction zone  mantle serpentinization  
Source directional apportionment of ambient PM2.5 in urban and industrial sites at a megacity in China 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Liu, Baoshuang;  Li, Yafei;  Wang, Lu;  Bi, Xiaohui;  Dong, Haiyan;  Sun, Xiaoyun;  Xiao, Zhimei;  Zhang, Yufen;  Feng, Yinchang
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Source directional apportionment (SDA)  PM2.5  Backward trajectory analysis  Positive matrix factorization (PMF)  
Oncometabolites suppress DNA repair by disrupting local chromatin signalling 期刊论文
NATURE, 2020
作者:  Zhang, Xu;  Lei, Bo;  Yuan, Yuan;  Zhang, Li;  Hu, Lu;  Jin, Sen;  Kang, Bilin;  Liao, Xuebin;  Sun, Wenzhi;  Xu, Fuqiang;  Zhong, Yi;  Hu, Ji;  Qi, Hai
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

Metabolites that are elevated in tumours inhibit the lysine demethylase KDM4B, resulting in aberrant hypermethylation of histone 3 lysine 9 and decreased homology-dependent DNA repair.


Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer(1). Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in human malignancies owing to somatic mutations in the isocitrate dehydrogenase-1 or -2 (IDH1 or IDH2) genes, or germline mutations in the fumarate hydratase (FH) and succinate dehydrogenase genes (SDHA, SDHB, SDHC and SDHD), respectively(2-4). Recent work has made an unexpected connection between these metabolites and DNA repair by showing that they suppress the pathway of homology-dependent repair (HDR)(5,6) and confer an exquisite sensitivity to inhibitors of poly (ADP-ribose) polymerase (PARP) that are being tested in clinical trials. However, the mechanism by which these oncometabolites inhibit HDR remains poorly understood. Here we determine the pathway by which these metabolites disrupt DNA repair. We show that oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that is essential for the proper execution of HDR. Consequently, recruitment of TIP60 and ATM, two key proximal HDR factors, is substantially impaired at DNA breaks, with reduced end resection and diminished recruitment of downstream repair factors. These findings provide a mechanistic basis for oncometabolite-induced HDR suppression and may guide effective strategies to exploit these defects for therapeutic gain.


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/03
Chemical Differences Between PM1 and PM2.5 in Highly Polluted Environment and Implications in Air Pollution Studies 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Sun, Yele;  He, Yao;  Kuang, Ye;  Xu, Wanyun;  Song, Shaojie;  Ma, Nan;  Tao, Jiangchuan;  Cheng, Peng;  Wu, Cheng;  Su, Hang;  Cheng, Yafang;  Xie, Conghui;  Chen, Chun;  Lei, Lu;  Qiu, Yanmei;  Fu, Pingqing;  Croteau, Philip;  Worsnop, Douglas R.
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/02
Fine particle characterization in a coastal city in China: composition, sources, and impacts of industrial emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2877-2890
作者:  Lei, Lu;  Xie, Conghui;  Wang, Dawei;  He, Yao;  Wang, Qingqing;  Zhou, Wei;  Hu, Wei;  Fu, Pingqing;  Chen, Yong;  Pan, Xiaole;  Wang, Zifa;  Worsnop, Douglas;  Sun, Yele
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
An unexpected catalyst dominates formation and radiative forcing of regional haze 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (8) : 3960-3966
作者:  Zhang, Fang;  Wang, Yuan;  Peng, Jianfei;  Chen, Lu;  Sun, Yele;  Duan, Lian;  Ge, Xinlei;  Li, Yixin;  Zhao, Jiayun;  Liu, Chao;  Zhang, Xiaochun;  Zhang, Gen;  Pan, Yuepeng;  Wang, Yuesi;  Zhang, Annie L.;  Ji, Yuemeng;  Wang, Gehui;  Hu, Min;  Molina, Mario J.;  Zhang, Renyi
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13
black carbon  air pollution  climate  multiphase chemistry  haze  
Improving Actual Evapotranspiration Estimation Integrating Energy Consumption for Ice Phase Change Across the Tibetan Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (3)
作者:  Wang, Genxu;  Lin, Shan;  Hu, Zhaoyong;  Lu, Yaqiong;  Sun, Xiangyang;  Huang, Kewei
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Contrasting size-resolved hygroscopicity of fine particles derived by HTDMA and HR-ToF-AMS measurements between summer and winter in Beijing: the impacts of aerosol aging and local emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 915-929
作者:  Fan, Xinxin;  Liu, Jieyao;  Zhang, Fang;  Chen, Lu;  Collins, Don;  Xu, Weiqi;  Jin, Xiaoai;  Ren, Jingye;  Wang, Yuying;  Wu, Hao;  Li, Shangze;  Sun, Yele;  Li, Zhanqing
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Mechanical regulation of glycolysis via cytoskeleton architecture 期刊论文
NATURE, 2020, 578 (7796) : 621-+
作者:  Faivre, Emily J.;  McDaniel, Keith F.;  Albert, Daniel H.;  Mantena, Srinivasa R.;  Plotnik, Joshua P.;  Wilcox, Denise;  Zhang, Lu;  Bui, Mai H.;  Sheppard, George S.;  Wang, Le;  Sehgal, Vasudha;  Lin, Xiaoyu;  Huang, Xiaoli;  Lu, Xin;  Uziel, Tamar;  Hessler, Paul;  Lam, Lloyd T.;  Bellin, Richard J.;  Mehta, Gaurav;  Fidanze, Steve;  Pratt, John K.;  Liu, Dachun;  Hasvold, Lisa A.;  Sun, Chaohong;  Panchal, Sanjay C.;  Nicolette, John J.;  Fossey, Stacey L.;  Park, Chang H.;  Longenecker, Kenton;  Bigelow, Lance;  Torrent, Maricel;  Rosenberg, Saul H.;  Kati, Warren M.;  Shen, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3). Although all of these processes consume energy(4,5), it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK). PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21). Transformed non-small-cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental mechanics, retain PFK expression by downregulating TRIM21, and by sequestering residual TRIM21 on a stress-fibre subset that is insensitive to substrate stiffness. Our data reveal a mechanism by which glycolysis responds to architectural features of the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surrounding tissue. These processes enable normal cells to tune energy production in variable microenvironments, whereas the resistance of the cytoskeleton in response to mechanical cues enables the persistence of high glycolytic rates in cancer cells despite constant alterations of the tumour tissue.


Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.