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Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
GEOS-S2S Version 2: The GMAO High-Resolution Coupled Model and Assimilation System for Seasonal Prediction 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (5)
作者:  Molod, Andrea;  Hackert, Eric;  Vikhliaev, Yury;  Zhao, Bin;  Barahona, Donifan;  Vernieres, Guillaume;  Borovikov, Anna;  Kovach, Robin M.;  Marshak, Jelena;  Schubert, Siegfried;  Li, Zhao;  Lim, Young-Kwon;  Andrews, Lauren C.;  Cullather, Richard;  Koster, Randal;  Achuthavarier, Deepthi;  Carton, James;  Coy, Lawrence;  Friere, Julliana L. M.;  Longo, Karla M.;  Nakada, Kazumi;  Pawson, Steven
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Atmosphere-Ocean Modeling  Atmosphere-Ocean Data Assimilation  Seasonal and Subseasonal Prediction  
Ice nucleation by aerosols from anthropogenic pollution 期刊论文
NATURE GEOSCIENCE, 2019, 12 (8) : 602-+
作者:  Zhao, Bin;  Wang, Yuan;  Gu, Yu;  Liou, Kuo-Nan;  Jiang, Jonathan H.;  Fan, Jiwen;  Liu, Xiaohong;  Huang, Lei;  Yung, Yuk L.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Trends and controls of terrestrial gross primary productivity of China during 2000-2016 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (8)
作者:  Ma, Jun;  Xiao, Xiangming;  Miao, Renhui;  Li, Yao;  Chen, Bangqian;  Zhang, Yao;  Zhao, Bin
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
vegetation productivity  breakpoints  trends shift  ecological restoration projects  climate change and land cover change  
Interannual variations of the rainy season withdrawal of the monsoon transitional zone in China 期刊论文
CLIMATE DYNAMICS, 2019, 53: 2031-2046
作者:  Zhao, Wei;  Chen, Shangfeng;  Chen, Wen;  Yao, Shuailei;  Nath, Debashis;  Yu, Bin
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Monsoon transitional zone  Withdrawal of rainy season  Northern tropical Atlantic SST  WNP anticyclone  Eurasian atmospheric teleconnection  
Modeling Study of the Air Quality Impact of Record-Breaking Southern California Wildfires in December 2017 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (12) : 6554-6570
作者:  Shi, Hongrong;  Jiang, Zhe;  Zhao, Bin;  Li, Zhijin;  Chen, Yang;  Gu, Yu;  Jiang, Jonathan H.;  Lee, Meemong;  Liou, Kuo-Nan;  Neu, Jessica L.;  Payne, Vivienne H.;  Su, Hui;  Wang, Yuan;  Witek, Marcin;  Worden, John
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Can kurtosis be an early warning signal for abrupt climate change? 期刊论文
CLIMATE DYNAMICS, 2019, 52 (11) : 6863-6876
作者:  Xie, Xiao-qiang;  He, Wen-ping;  Gu, Bin;  Mei, Ying;  Zhao, Shan-shan
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Early warning signal  Abrupt climate change  Kurtosis coefficient  Critical point  
Assessing aerosol indirect effect on clouds and regional climate of East/South Asia and West Africa using NCEP GFS 期刊论文
CLIMATE DYNAMICS, 2019, 52: 5759-5774
作者:  Huang, Huilin;  Gu, Yu;  Xue, Yongkang;  Jiang, Jonathan;  Zhao, Bin
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
Aerosol first indirect effect  AGCM  East Asia  West Africa  GOCART data