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Controls on surface water carbonate chemistry along North American ocean margins 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Cai, Wei-Jun;  Xu, Yuan-Yuan;  Feely, Richard A.;  Wanninkhof, Rik;  Jonsson, Bror;  Alin, Simone R.;  Barbero, Leticia;  Cross, Jessica N.;  Azetsu-Scott, Kumiko;  Fassbender, Andrea J.;  Carter, Brendan R.;  Jiang, Li-Qing;  Pepin, Pierre;  Chen, Baoshan;  Hussain, Najid;  Reimer, Janet J.;  Xue, Liang;  Salisbury, Joseph E.;  Martin Hernandez-Ayon, Jose;  Langdon, Chris;  Li, Qian;  Sutton, Adrienne J.;  Chen, Chen-Tung A.;  Gledhill, Dwight K.
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/09
The first dinosaur egg was soft 期刊论文
NATURE, 2020
作者:  Rodstrom, Karin E. J.;  Kiper, Aytug K.;  Zhang, Wei;  Rinne, Susanne;  Pike, Ashley C. W.;  Goldstein, Matthias;  Conrad, Linus J.;  Delbeck, Martina;  Hahn, Michael G.;  Meier, Heinrich;  Platzk, Magdalena;  Quigley, Andrew;  Speedman, David;  Shrestha, Leela;  Mukhopadhyay, Shubhashish M. M.
收藏  |  浏览/下载:47/0  |  提交时间:2020/07/03

Molecular analyses of newly discovered, embryo-bearing ornithischian and sauropod dinosaur eggs suggest that the ancestral dinosaur egg was soft-shelled, and that hard-shelled eggs evolved independently at least three times in the major dinosaur lineages.


Calcified eggshells protect developing embryos against environmental stress and contribute to reproductive success(1). As modern crocodilians and birds lay hard-shelled eggs, this eggshell type has been inferred for non-avian dinosaurs. Known dinosaur eggshells are characterized by an innermost membrane, an overlying protein matrix containing calcite, and an outermost waxy cuticle(2-7). The calcitic eggshell consists of one or more ultrastructural layers that differ markedly among the three major dinosaur clades, as do the configurations of respiratory pores. So far, only hadrosaurid, a few sauropodomorph and tetanuran eggshells have been discovered  the paucity of the fossil record and the lack of intermediate eggshell types challenge efforts to homologize eggshell structures across all dinosaurs(8-18). Here we present mineralogical, organochemical and ultrastructural evidence for an originally non-biomineralized, soft-shelled nature of exceptionally preserved ornithischianProtoceratopsand basal sauropodomorphMussauruseggs. Statistical evaluation of in situ Raman spectra obtained for a representative set of hard- and soft-shelled, fossil and extant diapsid eggshells clusters the originally organic but secondarily phosphatizedProtoceratopsand the organicMussauruseggshells with soft, non-biomineralized eggshells. Histology corroborates the organic composition of these soft-shelled dinosaur eggs, revealing a stratified arrangement resembling turtle soft eggshell. Through an ancestral-state reconstruction of composition and ultrastructure, we compare eggshells fromProtoceratopsandMussauruswith those from other diapsids, revealing that the first dinosaur egg was soft-shelled. The calcified, hard-shelled dinosaur egg evolved independently at least three times throughout the Mesozoic era, explaining the bias towards eggshells of derived dinosaurs in the fossil record.


  
De novo design of tunable, pH-driven conformational changes 期刊论文
SCIENCE, 2019, 364 (6441) : 658-+
作者:  Boyken, Scott E.;  Benhaim, Mark A.;  Busch, Florian;  Jia, Mengxuan;  Bick, Matthew J.;  Choi, Heejun;  Klima, Jason C.;  Chen, Zibo;  Walkey, Carl;  Mileant, Alexander;  Sahasrabuddhe, Aniruddha;  Wei, Kathy Y.;  Hodge, Edgar A.;  Byron, Sarah;  Quijano-Rubio, Alfredo;  Sankaran, Banumathi;  King, Neil P.;  Lippincott-Schwartz, Jennifer;  Wysocki, Vicki H.;  Lee, Kelly K.;  Baker, David
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
Observation of two-neutrino double electron capture in Xe-124 with XENON1T 期刊论文
NATURE, 2019, 568 (7753) : 532-+
作者:  Aprile, E.;  Aalbers, J.;  Agostini, F.;  Alfonsi, M.;  Althueser, L.;  Amaro, F. D.;  Anthony, M.;  Antochi, V. C.;  Arneodo, F.;  Baudis, L.;  Bauermeister, B.;  Benabderrahmane, L.;  Berger, T.;  Breur, P. A.;  Brown, A.;  Brown, A.;  Brown, E.;  Bruenner, S.;  Bruno, G.;  Budnik, R.;  Capelli, C.;  Cardoso, J. M. R.;  Cichon, D.;  Coderre, D.;  Colijn, A. P.;  Conrad, J.;  Cussonneau, J. P.;  Decowski, M. P.;  de Perio, P.;  Di Gangi, P.;  Di Giovanni, A.;  Diglio, S.;  Elykov, A.;  Eurin, G.;  Fei, J.;  Ferella, A. D.;  Fieguth, A.;  Fulgione, W.;  Rosso, A. Gallo;  Galloway, M.;  Gao, F.;  Garbini, M.;  Grandi, L.;  Greene, Z.;  Hasterok, C.;  Hogenbirk, E.;  Howlett, J.;  Iacovacci, M.;  Itay, R.;  Joerg, F.;  Kaminsky, B.;  Kazama, S.;  Kish, A.;  Koltman, G.;  Kopec, A.;  Landsman, H.;  Lang, R. F.;  Levinson, L.;  Lin, Q.;  Lindemann, S.;  Lindner, M.;  Lombardi, F.;  Lopes, J. A. M.;  Fune, E. Lopez;  Macolino, C.;  Mahlstedt, J.;  Manfredini, A.;  Marignetti, F.;  Undagoitia, T. Marrodan;  Masbou, J.;  Masson, D.;  Mastroianni, S.;  Messina, M.;  Micheneau, K.;  Miller, K.;  Molinario, A.;  Mora, K.;  Murra, M.;  Naganoma, J.;  Ni, K.;  Oberlack, U.;  Odgers, K.;  Pelssers, B.;  Peres, R.;  Piastra, F.;  Pienaar, J.;  Pizzella, V.;  Plante, G.;  Podviianiuk, R.;  Priel, N.;  Qiu, H.;  Garcia, D. Ramirez;  Reichard, S.;  Riedel, B.;  Rizzo, A.;  Rocchetti, A.;  Rupp, N.;  dos Santos, J. M. F.;  Sartorelli, G.;  Sarcevic, N.;  Scheibelhut, M.;  Schindler, S.;  Schreiner, J.;  Schulte, D.;  Schumann, M.;  Lavina, L. Scotto;  Selvi, M.;  Shagin, P.;  Shockley, E.;  Silva, M.;  Simgen, H.;  Therreau, C.;  Thers, D.;  Toschi, F.;  Trinchero, G.;  Tunnell, C.;  Upole, N.;  Vargas, M.;  Wack, O.;  Wang, H.;  Wang, Z.;  Wei, Y.;  Weinheimer, C.;  Wenz, D.;  Wittweg, C.;  Wulf, J.;  Ye, J.;  Zhang, Y.;  Zhu, T.;  Zopounidis, J. P.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Multicomponent intermetallic nanoparticles and superb mechanical behaviors of complex alloys 期刊论文
SCIENCE, 2018, 362 (6417) : 933-+
作者:  Yang, T.;  Zhao, Y. L.;  Tong, Y.;  Jiao, Z. B.;  Wei, J.;  Cai, J. X.;  Han, X. D.;  Chen, D.;  Hu, A.;  Kai, J. J.;  Lu, K.;  Liu, Y.;  Liu, C. T.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (23) : 5884-5889
作者:  Lee, Alysha K.;  Banta, Amy B.;  Wei, Jeremy H.;  Kiemle, David J.;  Feng, Ju;  Giner, Jose-Luis;  Welander, Paula, V
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
sterols  biomarkers  cyclic triterpenoids  Methylococcus capsulatus  
Measurement of the neutron lifetime using a magneto-gravitational trap and in situ detection 期刊论文
SCIENCE, 2018, 360 (6389) : 627-631
作者:  Pattie, R. W., Jr.;  Callahan, N. B.;  Cude-Woods, C.;  Adamek, E. R.;  Broussard, L. J.;  Clayton, S. M.;  Currie, S. A.;  Dees, E. B.;  Ding, X.;  Engel, E. M.;  Fellers, D. E.;  Fox, W.;  Geltenbort, P.;  Hickerson, K. P.;  Hoffbauer, M. A.;  Holley, A. T.;  Komives, A.;  Liu, C. -Y.;  MacDonald, S. W. T.;  Makela, M.;  Morris, C. L.;  Ortiz, J. D.;  Ramsey, J.;  Salvat, D. J.;  Saunders, A.;  Seestrom, S. J.;  Sharapov, E. I.;  Sjue, S. K.;  Tang, Z.;  Vanderwerp, J.;  Vogelaar, B.;  Walstrom, P. L.;  Wang, Z.;  Wei, W.;  Weaver, H. L.;  Wexler, J. W.;  Womack, T. L.;  Young, A. R.;  Zeck, B. A.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma 期刊论文
SCIENCE, 2018, 359 (6377) : 801-805
作者:  Miao, Diana;  Margolis, Claire A.;  Gao, Wenhua;  Voss, Martin H.;  Li, Wei;  Martini, Dylan J.;  Norton, Craig;  Bosse, Dominick;  Wankowicz, Stephanie M.;  Cullen, Dana;  Horak, Christine;  Wind-Rotolo, Megan;  Tracy, Adam;  Giannakis, Marios;  Hodi, Frank Stephen;  Drake, Charles G.;  Ball, Mark W.;  Allaf, Mohamad E.;  Snyder, Alexandra;  Hellmann, Matthew D.;  Ho, Thai;  Motzer, Robert J.;  Signoretti, Sabina;  Kaelin, William G., Jr.;  Choueiri, Toni K.;  Van Allen, Eliezer M.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients 期刊论文
SCIENCE, 2018, 359 (6371) : 97-103
作者:  Gopalakrishnan, V.;  Spencer, C. N.;  Nezi, L.;  Reuben, A.;  Andrews, M. C.;  Karpinets, T. V.;  Prieto, P. A.;  Vicente, D.;  Hoffman, K.;  Wei, S. C.;  Cogdill, A. P.;  Zhao, L.;  Hudgens, C. W.;  Hutchinson, D. S.;  Manzo, T.;  de Macedo, M. Petaccia;  Cotechini, T.;  Kumar, T.;  Chen, W. S.;  Reddy, S. M.;  Sloane, R. Szczepaniak;  Galloway-Pena, J.;  Jiang, H.;  Chen, P. L.;  Shpall, E. J.;  Rezvani, K.;  Alousi, A. M.;  Chemaly, R. F.;  Shelburne, S.;  Vence, L. M.;  Okhuysen, P. C.;  Jensen, V. B.;  Swennes, A. G.;  McAllister, F.;  Sanchez, E. Marcelo Riquelme;  Zhang, Y.;  Le Chatelier, E.;  Zitvogel, L.;  Pons, N.;  Austin-Breneman, J. L.;  Haydu, L. E.;  Burton, E. M.;  Gardner, J. M.;  Sirmans, E.;  Hu, J.;  Lazar, A. J.;  Tsujikawa, T.;  Diab, A.;  Tawbi, H.;  Glitza, I. C.;  Hwu, W. J.;  Patel, S. P.;  Woodman, S. E.;  Amaria, R. N.;  Davies, M. A.;  Gershenwald, J. E.;  Hwu, P.;  Lee, J. E.;  Zhang, J.;  Coussens, L. M.;  Cooper, Z. A.;  Futreal, P. A.;  Daniel, C. R.;  Ajami, N. J.;  Petrosino, J. F.;  Tetzlaff, M. T.;  Sharma, P.;  Allison, J. P.;  Jenq, R. R.;  Wargo, J. A.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils 期刊论文
SCIENCE, 2017, 358 (6367)
作者:  Engblom, Camilla;  Pfirschke, Christina;  Zilionis, Rapolas;  Martins, Janaina Da Silva;  Bos, Stijn A.;  Courties, Gabriel;  Rickelt, Steffen;  Severe, Nicolas;  Baryawno, Ninib;  Faget, Julien;  Savova, Virginia;  Zemmour, David;  Kline, Jaclyn;  Siwicki, Marie;  Garris, Christopher;  Pucci, Ferdinando;  Liao, Hsin-Wei;  Lin, Yi-Jang;  Newton, Andita;  Yaghi, Omar K.;  Iwamoto, Yoshiko;  Tricot, Benoit;  Wojtkiewicz, Gregory R.;  Nahrendorf, Matthias;  Cortez-Retamozo, Virna;  Meylan, Etienne;  Hynes, Richard O.;  Demay, Marie;  Klein, Allon;  Bredella, Miriam A.;  Scadden, David T.;  Weissleder, Ralph;  Pittet, Mikael J.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27