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Global conservation of species' niches 期刊论文
NATURE, 2020, 580 (7802) : 232-+
作者:  Guo, Xiaoyan;  Aviles, Giovanni;  Liu, Yi;  Tian, Ruilin;  Unger, Bret A.;  Lin, Yu-Hsiu T.;  Wiita, Arun P.;  Xu, Ke;  Correia, M. Almira;  Kampmann, Martin
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/03

Environmental change is rapidly accelerating, and many species will need to adapt to survive(1). Ensuring that protected areas cover populations across a broad range of environmental conditions could safeguard the processes that lead to such adaptations(1-3). However, international conservation policies have largely neglected these considerations when setting targets for the expansion of protected areas(4). Here we show that-of 19,937 vertebrate species globally(5-8)-the representation of environmental conditions across their habitats in protected areas (hereafter, niche representation) is inadequate for 4,836 (93.1%) amphibian, 8,653 (89.5%) bird and 4,608 (90.9%) terrestrial mammal species. Expanding existing protected areas to cover these gaps would encompass 33.8% of the total land surface-exceeding the current target of 17% that has been adopted by governments. Priority locations for expanding the system of protected areas to improve niche representation occur in global biodiversity hotspots(9), including Colombia, Papua New Guinea, South Africa and southwest China, as well as across most of the major land masses of the Earth. Conversely, we also show that planning for the expansion of protected areas without explicitly considering environmental conditions would marginally reduce the land area required to 30.7%, but that this would lead to inadequate niche representation for 7,798 (39.1%) species. As the governments of the world prepare to renegotiate global conservation targets, policymakers have the opportunity to help to maintain the adaptive potential of species by considering niche representation within protected areas(1,2).


Protected areas would need to expand to 33.8% of the total land surface to adequately represent environmental conditions across the habitats of amphibians, birds and terrestrial mammals, far exceeding the current 17% target.


  
Centrosome anchoring regulates progenitor properties and cortical formation 期刊论文
NATURE, 2020
作者:  Guo, Xiaoyan;  Aviles, Giovanni;  Liu, Yi;  Tian, Ruilin;  Unger, Bret A.;  Lin, Yu-Hsiu T.;  Wiita, Arun P.;  Xu, Ke;  Correia, M. Almira;  Kampmann, Martin
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

CEP83-mediated anchoring of the centrosome to the apical membrane in radial glial progenitor cells regulates their mechanical properties and thereby influences the size and configuration of the mammalian cortex.


Radial glial progenitor cells (RGPs) are the major neural progenitor cells that generate neurons and glia in the developing mammalian cerebral cortex(1-4). In RGPs, the centrosome is positioned away from the nucleus at the apical surface of the ventricular zone of the cerebral cortex(5-8). However, the molecular basis and precise function of this distinctive subcellular organization of the centrosome are largely unknown. Here we show in mice that anchoring of the centrosome to the apical membrane controls the mechanical properties of cortical RGPs, and consequently their mitotic behaviour and the size and formation of the cortex. The mother centriole in RGPs develops distal appendages that anchor it to the apical membrane. Selective removal of centrosomal protein 83 (CEP83) eliminates these distal appendages and disrupts the anchorage of the centrosome to the apical membrane, resulting in the disorganization of microtubules and stretching and stiffening of the apical membrane. The elimination of CEP83 also activates the mechanically sensitive yes-associated protein (YAP) and promotes the excessive proliferation of RGPs, together with a subsequent overproduction of intermediate progenitor cells, which leads to the formation of an enlarged cortex with abnormal folding. Simultaneous elimination of YAP suppresses the cortical enlargement and folding that is induced by the removal of CEP83. Together, these results indicate a previously unknown role of the centrosome in regulating the mechanical features of neural progenitor cells and the size and configuration of the mammalian cerebral cortex.


  
Ice front blocking of ocean heat transport to an Antarctic ice shelf 期刊论文
NATURE, 2020, 578 (7796) : 568-+
作者:  Alexandrov, Ludmil B.;  Kim, Jaegil;  Haradhvala, Nicholas J.;  Huang, Mi Ni;  Ng, Alvin Wei Tian;  Wu, Yang;  Boot, Arnoud;  Covington, Kyle R.;  Gordenin, Dmitry A.;  Bergstrom, Erik N.;  Islam, S. M. Ashiqul;  Lopez-Bigas, Nuria;  Klimczak, Leszek J.;  McPherson, John R.;  Morganella, Sandro;  Sabarinathan, Radhakrishnan;  Wheeler, David A.;  Mustonen, Ville;  Getz, Gad;  Rozen, Steven G.;  Stratton, Michael R.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13

The front of the Getz Ice Shelf in West Antarctica creates an abrupt topographic step that deflects ocean currents, suppressing 70% of the heat delivery to the ice sheet.


Mass loss from the Antarctic Ice Sheet to the ocean has increased in recent decades, largely because the thinning of its floating ice shelves has allowed the outflow of grounded ice to accelerate(1,2). Enhanced basal melting of the ice shelves is thought to be the ultimate driver of change(2,3), motivating a recent focus on the processes that control ocean heat transport onto and across the seabed of the Antarctic continental shelf towards the ice(4-6). However, the shoreward heat flux typically far exceeds that required to match observed melt rates(2,7,8), suggesting that other critical controls exist. Here we show that the depth-independent (barotropic) component of the heat flow towards an ice shelf is blocked by the marked step shape of the ice front, and that only the depth-varying (baroclinic) component, which is typically much smaller, can enter the sub-ice cavity. Our results arise from direct observations of the Getz Ice Shelf system and laboratory experiments on a rotating platform. A similar blocking of the barotropic component may occur in other areas with comparable ice-bathymetry configurations, which may explain why changes in the density structure of the water column have been found to be a better indicator of basal melt rate variability than the heat transported onto the continental shelf(9). Representing the step topography of the ice front accurately in models is thus important for simulating ocean heat fluxes and induced melt rates.


  
Acceleration of global N2O emissions seen from two decades of atmospheric inversion 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (12) : 993-+
作者:  Thompson, R. L.;  Lassaletta, L.;  Patra, P. K.;  Wilson, C.;  Wells, K. C.;  Gressent, A.;  Koffi, E. N.;  Chipperfield, M. P.;  Winiwarter, W.;  Davidson, E. A.;  Tian, H.;  Canadell, J. G.
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/16
Oligomeric state of the ZIKV E protein defines protective immune responses 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Metz, Stefan W.;  Thomas, Ashlie;  Brackbill, Alex;  Forsberg, John;  Miley, Michael J.;  Lopez, Cesar A.;  Lazear, Helen M.;  Tian, Shaomin;  de Silva, Aravinda M.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Global vegetation biomass production efficiency constrained by models and observations 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  He, Yue;  Peng, Shushi;  Liu, Yongwen;  Li, Xiangyi;  Wang, Kai;  Ciais, Philippe;  Arain, M. Altaf;  Fang, Yuanyuan;  Fisher, Joshua B.;  Goll, Daniel;  Hayes, Daniel;  Huntzinger, Deborah N.;  Ito, Akihiko;  Jain, Atul K.;  Janssens, Ivan A.;  Mao, Jiafu;  Matteo, Campioli;  Michalak, Anna M.;  Peng, Changhui;  Penuelas, Josep;  Poulter, Benjamin;  Qin, Dahe;  Ricciuto, Daniel M.;  Schaefer, Kevin;  Schwalm, Christopher R.;  Shi, Xiaoying;  Tian, Hanqin;  Vicca, Sara;  Wei, Yaxing;  Zeng, Ning;  Zhu, Qiuan
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
biomass production  BPE  carbon sink  emergent constraint  terrestrial biosphere model  
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan (vol 8, 2270, 2017) 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Wang, Chensu;  Niederstrasser, Hanspeter;  Douglas, Peter M.;  Lin, Rueyling;  Jaramillo, Juan;  Li, Yang;  Oswald, Nathaniel W.;  Zhou, Anwu;  McMillan, Elizabeth A.;  Mendiratta, Saurabh;  Wang, Zhaohui;  Zhao, Tian;  Lin, Zhiqaing;  Luo, Min;  Huang, Gang;  Brekken, Rolf A.;  Posner, Bruce A.;  MacMillan, John B.;  Gao, Jinming;  White, Michael A.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior 期刊论文
SCIENCE, 2019, 365 (6456) : 882-+
作者:  Ganna, Andrea;  Verweij, Karin J. H.;  Nivard, Michel G.;  Maier, Robert;  Wedow, Robbee;  Busch, Alexander S.;  Abdellaoui, Abdel;  Guo, Shengru;  Sathirapongsasuti, J. Fah;  Lichtenstein, Paul;  Lundstrom, Sebastian;  Langstrom, Niklas;  Auton, Adam;  Harris, Kathleen Mullan;  Beecham, Gary W.;  Martin, Eden R.;  Sanders, Alan R.;  Perry, John R. B.;  Neale, Benjamin M.;  Zietsch, Brendan P.;  Agee, M.;  Alipanahi, B.;  Auton, A.;  Bell, R. K.;  Bryc, K.;  Elson, S. L.;  Fontanillas, P.;  Furlotte, N. A.;  Hicks, B.;  Huber, K. E.;  Jewett, E. M.;  Jiang, Y.;  Kleinman, A.;  Lin, K. -H.;  Litterman, N. K.;  McCreight, J. C.;  McIntyre, M. H.;  McManus, K. F.;  Mountain, J. L.;  Noblin, E. S.;  Northover, C. A. M.;  Pitts, S. J.;  Poznik, G. D.;  Shastri, A. J.;  Shelton, J. F.;  Shringarpure, S.;  Tian, C.;  Tung, J. Y.;  Vacic, V.;  Wang, X.;  Wilson, C. H.
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/27
Terahertz field-induced ferroelectricity in quantum paraelectric SrTiO3 期刊论文
SCIENCE, 2019, 364 (6445) : 1079-+
作者:  Li, Xian;  Qiu, Tian;  Zhang, Jiahao;  Baldini, Edoardo;  Lu, Jian;  Rappe, Andrew M.;  Nelson, Keith A.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Tian, Bining;  Fernandez-Bravo, Angel;  Najafiaghdam, Hossein;  Torquato, Nicole A.;  Altoe, M. Virginia P.;  Teitelboim, Ayelet;  Tajon, Cheryl A.;  Tian, Yue;  Borys, Nicholas J.;  Barnard, Edward S.;  Anwar, Mekhail;  Chan, Emory M.;  Schuck, P. James;  Cohen, Bruce E.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27