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DOI | 10.1038/s41467-019-09761-2 |
Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals | |
Tian, Bining1; Fernandez-Bravo, Angel1; Najafiaghdam, Hossein2; Torquato, Nicole A.1,3; Altoe, M. Virginia P.1; Teitelboim, Ayelet1; Tajon, Cheryl A.1; Tian, Yue1; Borys, Nicholas J.1; Barnard, Edward S.1; Anwar, Mekhail3; Chan, Emory M.1; Schuck, P. James1,4; Cohen, Bruce E.1 | |
2019-04-30 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Multiphoton imaging techniques that convert low-energy excitation to higher energy emission are widely used to improve signal over background, reduce scatter, and limit photodamage. Lanthanide-doped upconverting nanoparticles (UCNPs) are among the most efficient multiphoton probes, but even UCNPs with optimized lanthanide dopant levels require laser intensities that may be problematic. Here, we develop protein-sized, alloyed UCNPs (aUCNPs) that can be imaged individually at laser intensities >300-fold lower than needed for comparably sized doped UCNPs. Using single UCNP characterization and kinetic modeling, we find that addition of inert shells changes optimal lanthanide content from Yb3+, Er3+-doped NaYF4 nanocrystals to fully alloyed compositions. At high levels, emitter Er3+ ions can adopt a second role to enhance aUCNP absorption cross-section by desaturating sensitizer Yb3+ or by absorbing photons directly. Core/shell aUCNPs 12 nm in total diameter can be imaged through deep tissue in live mice using a laser intensity of 0.1 Wcm(-2). |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000440777000012 |
WOS关键词 | UP-CONVERSION LUMINESCENCE ; DOPED NANOCRYSTALS ; UPCONVERTING NANOCRYSTALS ; SUB-10 NM ; FLUORESCENCE ; MICROSCOPY ; NANOPARTICLES ; CELLS ; CORE ; NANOSTRUCTURE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204347 |
专题 | 资源环境科学 |
作者单位 | 1.Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA; 2.Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA; 3.Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94158 USA; 4.Columbia Univ, Dept Mech Engn, New York, NY 10027 USA |
推荐引用方式 GB/T 7714 | Tian, Bining,Fernandez-Bravo, Angel,Najafiaghdam, Hossein,et al. Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Tian, Bining.,Fernandez-Bravo, Angel.,Najafiaghdam, Hossein.,Torquato, Nicole A..,Altoe, M. Virginia P..,...&Cohen, Bruce E..(2019).Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals.NATURE COMMUNICATIONS,9. |
MLA | Tian, Bining,et al."Low irradiance multiphoton imaging with alloyed lanthanide nanocrystals".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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