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Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy 期刊论文
Science, 2020
作者:  Hongjing Gu;  Qi Chen;  Guan Yang;  Lei He;  Hang Fan;  Yong-Qiang Deng;  Yanxiao Wang;  Yue Teng;  Zhongpeng Zhao;  Yujun Cui;  Yuchang Li;  Xiao-Feng Li;  Jiangfan Li;  Na-Na Zhang;  Xiaolan Yang;  Shaolong Chen;  Yan Guo;  Guangyu Zhao;  Xiliang Wang;  De-Yan Luo;  Hui Wang;  Xiao Yang;  Yan Li;  Gencheng Han;  Yuxian He;  Xiaojun Zhou;  Shusheng Geng;  Xiaoli Sheng;  Shibo Jiang;  Shihui Sun;  Cheng-Feng Qin;  Yusen Zhou
收藏  |  浏览/下载：17/0  |  提交时间：2020/09/30
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2 期刊论文
Science, 2020
作者:  Jianzhong Shi;  Zhiyuan Wen;  Gongxun Zhong;  Huanliang Yang;  Chong Wang;  Baoying Huang;  Renqiang Liu;  Xijun He;  Lei Shuai;  Ziruo Sun;  Yubo Zhao;  Peipei Liu;  Libin Liang;  Pengfei Cui;  Jinliang Wang;  Xianfeng Zhang;  Yuntao Guan;  Wenjie Tan;  Guizhen Wu;  Hualan Chen;  Zhigao Bu
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/01
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Plastic pollution in croplands threatens long‐term food security 期刊论文
Global Change Biology, 2020
作者:  Dan Zhang;  Ee Ling Ng;  Wanli Hu;  Hongyuan Wang;  Pablo Galaviz;  Hude Yang;  Wentao Sun;  Chongxiao Li;  Xingwang Ma;  Bin Fu;  Peiyi Zhao;  Fulin Zhang;  Shuqin Jin;  Mingdong Zhou;  Lianfeng Du;  Chang Peng;  Xuejun Zhang;  Zhiyu Xu;  Bin Xi;  Xiaoxia Liu;  Shiyou Sun;  Zhenhua Cheng;  Lihua Jiang;  Yufeng Wang;  Liang Gong;  Changlin Kou;  Yan Li;  Youhua Ma;  Dongfeng Huang;  Jian Zhu;  Jianwu Yao;  Chaowen Lin;  Song Qin;  Liuqiang Zhou;  Binghui He;  Deli Chen;  Huanchun Li;  Limei Zhai;  Qiuliang Lei;  Shuxia Wu;  Yitao Zhang;  Junting Pan;  Baojing Gu;  Hongbin Liu
收藏  |  浏览/下载：13/0  |  提交时间：2020/05/13
Chemical Differences Between PM1 and PM2.5 in Highly Polluted Environment and Implications in Air Pollution Studies 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Sun, Yele;  He, Yao;  Kuang, Ye;  Xu, Wanyun;  Song, Shaojie;  Ma, Nan;  Tao, Jiangchuan;  Cheng, Peng;  Wu, Cheng;  Su, Hang;  Cheng, Yafang;  Xie, Conghui;  Chen, Chun;  Lei, Lu;  Qiu, Yanmei;  Fu, Pingqing;  Croteau, Philip;  Worsnop, Douglas R.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/02
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).