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A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/22
Large Chinese land carbon sink estimated from atmospheric carbon dioxide data 期刊论文
Nature, 2020
作者:  Jing Wang;  Liang Feng;  Paul I. Palmer;  Yi Liu;  Shuangxi Fang;  Hartmut Bö;  sch;  Christopher W. O’;  Dell;  Xiaoping Tang;  Dongxu Yang;  Lixin Liu;  ChaoZong Xia
收藏  |  浏览/下载：13/0  |  提交时间：2020/11/09
An orally available non-nucleotide STING agonist with antitumor activity 期刊论文
Science, 2020
作者:  Bo-Sheng Pan;  Samanthi A. Perera;  Jennifer A. Piesvaux;  Jeremy P. Presland;  Gottfried K. Schroeder;  Jared N. Cumming;  B. Wesley Trotter;  Michael D. Altman;  Alexei V. Buevich;  Brandon Cash;  Saso Cemerski;  Wonsuk Chang;  Yiping Chen;  Peter J. Dandliker;  Guo Feng;  Andrew Haidle;  Timothy Henderson;  James Jewell;  Ilona Kariv;  Ian Knemeyer;  Johnny Kopinja;  Brian M. Lacey;  Jason Laskey;  Charles A. Lesburg;  Rui Liang;  Brian J. Long;  Min Lu;  Yanhong Ma;  Ellen C. Minnihan;  Greg O’Donnell;  Ryan Otte;  Laura Price;  Larissa Rakhilina;  Berengere Sauvagnat;  Sharad Sharma;  Sriram Tyagarajan;  Hyun Woo;  Daniel F. Wyss;  Serena Xu;  David Jonathan Bennett;  George H. Addona
收藏  |  浏览/下载：14/0  |  提交时间：2020/08/25
Photoperiod and temperature as dominant environmental drivers triggering secondary growth resumption in Northern Hemisphere conifers 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Jian-Guo Huang;  Qianqian Ma;  Sergio Rossi;  Franco Biondi;  Annie Deslauriers;  Patrick Fonti;  Eryuan Liang;  Harri Mäkinen;  Walter Oberhuber;  Cyrille B. K. Rathgeber;  Roberto Tognetti;  Václav Treml;  Bao Yang;  Jiao-Lin Zhang;  Serena Antonucci;  Yves Bergeron;  J. Julio Camarero;  Filipe Campelo;  Katarina Čufar;  Henri E. Cuny;  Martin De Luis;  Alessio Giovannelli;  Jožica Gričar;  Andreas Gruber;  Vladimír Gryc;  Aylin Güney;  Xiali Guo;  Wei Huang;  Tuula Jyske;  Jakub Kašpar;  Gregory King;  Cornelia Krause;  Audrey Lemay;  Feng Liu;  Fabio Lombardi;  Edurne Martinez del Castillo;  Hubert Morin;  Cristina Nabais;  Pekka Nöjd;  Richard L. Peters;  Peter Prislan;  Antonio Saracino;  Irene Swidrak;  Hanuš Vavrčík;  Joana Vieira;  Biyun Yu;  Shaokang Zhang;  Qiao Zeng;  Yaling Zhang;  Emanuele Ziaco
收藏  |  浏览/下载：15/0  |  提交时间：2020/08/18
Measuring aquifer specific yields with absolute gravimetry: result in the Choushui River Alluvial Fan and Mingchu Basin, central Taiwan 期刊论文
Water Resources Research, 2020
作者:  Kuan‐;  Hung Chen;  Cheinway Hwang;  Liang‐;  Cheng Chang;  Jui‐;  Pin Tsai;  Tian‐;  Chyi Jim Yeh;  Ching‐;  Chung Cheng;  Chien‐;  Chung Ke;  Wei Feng
收藏  |  浏览/下载：7/0  |  提交时间：2020/06/16
Tunable topological charge vortex microlaser 期刊论文
Science, 2020
作者:  Zhifeng Zhang;  Xingdu Qiao;  Bikashkali Midya;  Kevin Liu;  Jingbo Sun;  Tianwei Wu;  Wenjing Liu;  Ritesh Agarwal;  Josep Miquel Jornet;  Stefano Longhi;  Natalia M. Litchinitser;  Liang Feng
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/20
Photocurrent detection of the orbital angular momentum of light 期刊论文
Science, 2020
作者:  Zhurun Ji;  Wenjing Liu;  Sergiy Krylyuk;  Xiaopeng Fan;  Zhifeng Zhang;  Anlian Pan;  Liang Feng;  Albert Davydov;  Ritesh Agarwal
收藏  |  浏览/下载：14/0  |  提交时间：2020/05/20
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/03
Saving less in China facilitates global CO2 mitigation 期刊论文
Nature, 2020
作者:  Chen Lin;  Jianchuan Qi;  Sai Liang;  Cuiyang Feng;  Thomas O. Wiedmann;  Yihan Liao;  Xuechun Yang;  Yumeng Li;  Zhifu Mi;  Zhifeng Yang
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13