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Evolution and epidemic spread of SARS-CoV-2 in Brazil 期刊论文
Science, 2020
作者:  Darlan S. Candido;  Ingra M. Claro;  Jaqueline G. de Jesus;  William M. Souza;  Filipe R. R. Moreira;  Simon Dellicour;  Thomas A. Mellan;  Louis du Plessis;  Rafael H. M. Pereira;  Flavia C. S. Sales;  Erika R. Manuli;  Julien Thézé;  Luiz Almeida;  Mariane T. Menezes;  Carolina M. Voloch;  Marcilio J. Fumagalli;  Thaís M. Coletti;  Camila A. M. da Silva;  Mariana S. Ramundo;  Mariene R. Amorim;  Henrique H. Hoeltgebaum;  Swapnil Mishra;  Mandev S. Gill;  Luiz M. Carvalho;  Lewis F. Buss;  Carlos A. Prete;  Jordan Ashworth;  Helder I. Nakaya;  Pedro S. Peixoto;  Oliver J. Brady;  Samuel M. Nicholls;  Amilcar Tanuri;  Átila D. Rossi;  Carlos K. V. Braga;  Alexandra L. Gerber;  Ana Paula de C. Guimarães;  Nelson Gaburo;  Cecila Salete Alencar;  Alessandro C. S. Ferreira;  Cristiano X. Lima;  José Eduardo Levi;  Celso Granato;  Giulia M. Ferreira;  Ronaldo S. Francisco;  Fabiana Granja;  Marcia T. Garcia;  Maria Luiza Moretti;  Mauricio W. Perroud;  Terezinha M. P. P. Castiñeiras;  Carolina S. Lazari;  Sarah C. Hill;  Andreza Aruska de Souza Santos;  Camila L. Simeoni;  Julia Forato;  Andrei C. Sposito;  Angelica Z. Schreiber;  Magnun N. N. Santos;  Camila Zolini de Sá;  Renan P. Souza;  Luciana C. Resende-Moreira;  Mauro M. Teixeira;  Josy Hubner;  Patricia A. F. Leme;  Rennan G. Moreira;  Maurício L. Nogueira;  Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology Genomic Network;  Neil M. Ferguson;  Silvia F. Costa;  José Luiz Proenca-Modena;  Ana Tereza R. Vasconcelos;  Samir Bhatt;  Philippe Lemey;  Chieh-Hsi Wu;  Andrew Rambaut;  Nick J. Loman;  Renato S. Aguiar;  Oliver G. Pybus;  Ester C. Sabino;  Nuno Rodrigues Faria
收藏  |  浏览/下载:13/0  |  提交时间:2020/09/08
A reaction chamber for chromatin modification 期刊论文
NATURE, 2020, 579 (7800) : 503-504
作者:  Inomata, Takeshi;  Triadan, Daniela;  Vazquez Lopez, Veronica A.;  Fernandez-Diaz, Juan Carlos;  Omori, Takayuki;  Mendez Bauer, Maria Belen;  Garcia Hernandez, Melina;  Beach, Timothy;  Cagnato, Clarissa;  Aoyama, Kazuo;  Nasu, Hiroo
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

Chromatin, the complex of DNA and protein in cell nuclei, can be modified by ubiquitin molecules. It emerges that this modification occurs in a molecular reaction chamber formed from an enzyme and a scaffold protein.


A phase-separated reaction chamber for chromatin ubiquitination.


  
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I 期刊论文
NATURE, 2020, 581 (7806) : 100-+
作者:  Waszak, Sebastian M.;  Robinson, Giles W.;  Gudenas, Brian L.;  Smith, Kyle S.;  Forget, Antoine;  Kojic, Marija;  Garcia-Lopez, Jesus;  Hadley, Jennifer;  Hamilton, Kayla V.;  Indersie, Emilie;  Buchhalter, Ivo;  Kerssemakers, Jules;  Jager, Natalie;  Sharma, Tanvi;  Rausch, Tobias;  Kool, Marcel;  Sturm, Dominik;  Jones, David T. W.;  Vasilyeva, Aksana;  Tatevossian, Ruth G.;  Neale, Geoffrey;  Lombard, Berangere;  Loew, Damarys;  Nakitandwe, Joy;  Rusch, Michael;  Bowers, Daniel C.;  Bendel, Anne;  Partap, Sonia;  Chintagumpala, Murali;  Crawford, John;  Gottardo, Nicholas G.;  Smith, Amy;  Dufour, Christelle;  Rutkowski, Stefan;  Eggen, Tone;  Wesenberg, Finn;  Kjaerheim, Kristina;  Feychting, Maria;  Lannering, Birgitta;  Schuz, Joachim;  Johansen, Christoffer;  Andersen, Tina V.;  Roosli, Martin;  Kuehni, Claudia E.;  Grotzer, Michael;  Remke, Marc;  Puget, Stephanie;  Pajtler, Kristian W.;  Milde, Till;  Witt, Olaf;  Ryzhova, Marina;  Korshunov, Andrey;  Orr, Brent A.;  Ellison, David W.;  Brugieres, Laurence;  Lichter, Peter;  Nichols, Kim E.;  Gajjar, Amar;  Wainwright, Brandon J.;  Ayrault, Olivier;  Korbel, Jan O.;  Northcott, Paul A.;  Pfister, Stefan M.
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/03

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint blockade (ICB) therapy(1-3). However, in pancreatic ductal adenocarcinoma (PDAC), which is resistant to most therapies including ICB4, mutations that cause loss of MHC-I are rarely found(5) despite the frequent downregulation of MHC-I expression(6-8). Here we show that, in PDAC, MHC-I molecules are selectively targeted for lysosomal degradation by an autophagy-dependent mechanism that involves the autophagy cargo receptor NBR1. PDAC cells display reduced expression of MHC-I at the cell surface and instead demonstrate predominant localization within autophagosomes and lysosomes. Notably, inhibition of autophagy restores surface levels of MHC-I and leads to improved antigen presentation, enhanced anti-tumour T cell responses and reduced tumour growth in syngeneic host mice. Accordingly, the anti-tumour effects of autophagy inhibition are reversed by depleting CD8(+) T cells or reducing surface expression of MHC-I. Inhibition of autophagy, either genetically or pharmacologically with chloroquine, synergizes with dual ICB therapy (anti-PD1 and anti-CTLA4 antibodies), and leads to an enhanced anti-tumour immune response. Our findings demonstrate a role for enhanced autophagy or lysosome function in immune evasion by selective targeting of MHC-I molecules for degradation, and provide a rationale for the combination of autophagy inhibition and dual ICB therapy as a therapeutic strategy against PDAC.


Inhibition of the autophagy-lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8(+) T cells.


  
Global gene flow releases invasive plants from environmental constraints on genetic diversity 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (8) : 4218-4227
作者:  Smith, Annabel L.;  Hodkinson, Trevor R.;  Villellas, Jesus;  Catford, Jane A.;  Csergo, Anna Maria;  Blomberg, Simone P.;  Crone, Elizabeth E.;  Ehrlen, Johan;  Garcia, Maria B.;  Laine, Anna-Liisa;  Roach, Deborah A.;  Salguero-Gomez, Roberto;  Wardle, Glenda M.;  Childs, Dylan Z.;  Elderd, Bret D.;  Finn, Alain;  Munne-Bosch, Sergi;  Baudraz, Maude E. A.;  Bodis, Judit;  Brearley, Francis Q.;  Bucharova, Anna;  Caruso, Christina M.;  Duncan, Richard P.;  Dwyerh, Johnm.;  Gooden, Ben;  Groenteman, Ronny;  Hamre, Liv Norunn;  Helm, Aveliina;  Kelly, Ruth;  Laanisto, Lauri;  Lonati, Michele;  Moore, Joslin L.;  Morales, Melanie;  Olsen, Siri Lie;  Partel, Meelis;  Petry, William K.;  Ramula, Satu;  Rasmussen, Pil U.;  Enri, Simone Ravetto;  Roeder, Anna;  Roscher, Christiane;  Saastamoinen, Marjo;  Tack, Ayco J. M.;  Topper, Joachim Paul;  Vose, Gregory E.;  Wandrag, Elizabeth M.;  Wingler, Astrid;  Buckley, Yvonne M.
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
plant invasion  adaptation  global change  population genetics  demography