Evolution and epidemic spread of SARS-CoV-2 in Brazil

doi:10.1126/science.abd2161

GSTDTAP > 气候变化

DOI	10.1126/science.abd2161
	Evolution and epidemic spread of SARS-CoV-2 in Brazil
	Darlan S. Candido; Ingra M. Claro; Jaqueline G. de Jesus; William M. Souza; Filipe R. R. Moreira; Simon Dellicour; Thomas A. Mellan; Louis du Plessis; Rafael H. M. Pereira; Flavia C. S. Sales; Erika R. Manuli; Julien Thézé; Luiz Almeida; Mariane T. Menezes; Carolina M. Voloch; Marcilio J. Fumagalli; Thaís M. Coletti; Camila A. M. da Silva; Mariana S. Ramundo; Mariene R. Amorim; Henrique H. Hoeltgebaum; Swapnil Mishra; Mandev S. Gill; Luiz M. Carvalho; Lewis F. Buss; Carlos A. Prete; Jordan Ashworth; Helder I. Nakaya; Pedro S. Peixoto; Oliver J. Brady; Samuel M. Nicholls; Amilcar Tanuri; Átila D. Rossi; Carlos K. V. Braga; Alexandra L. Gerber; Ana Paula de C. Guimarães; Nelson Gaburo; Cecila Salete Alencar; Alessandro C. S. Ferreira; Cristiano X. Lima; José Eduardo Levi; Celso Granato; Giulia M. Ferreira; Ronaldo S. Francisco; Fabiana Granja; Marcia T. Garcia; Maria Luiza Moretti; Mauricio W. Perroud; Terezinha M. P. P. Castiñeiras; Carolina S. Lazari; Sarah C. Hill; Andreza Aruska de Souza Santos; Camila L. Simeoni; Julia Forato; Andrei C. Sposito; Angelica Z. Schreiber; Magnun N. N. Santos; Camila Zolini de Sá; Renan P. Souza; Luciana C. Resende-Moreira; Mauro M. Teixeira; Josy Hubner; Patricia A. F. Leme; Rennan G. Moreira; Maurício L. Nogueira; Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology Genomic Network; Neil M. Ferguson; Silvia F. Costa; José Luiz Proenca-Modena; Ana Tereza R. Vasconcelos; Samir Bhatt; Philippe Lemey; Chieh-Hsi Wu; Andrew Rambaut; Nick J. Loman; Renato S. Aguiar; Oliver G. Pybus; Ester C. Sabino; Nuno Rodrigues Faria
	2020-09-04
发表期刊	Science
出版年	2020
英文摘要	Brazil has been hard-hit by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Candido et al. combined genomic and epidemiological analyses to investigate the impact of nonpharmaceutical interventions (NPIs) in the country. By setting up a network of genomic laboratories using harmonized protocols, the researchers found a 29% positive rate for SARS-CoV-2 among collected samples. More than 100 international introductions of SARS-CoV-2 into Brazil were identified, including three clades introduced from Europe that were already well established before the implementation of NPIs and travel bans. The virus spread from urban centers to the rest of the country, along with a 25% increase in the average distance traveled by air passengers before travel bans, despite an overall drop in short-haul travel. Unfortunately, the evidence confirms that current interventions remain insufficient to keep virus transmission under control in Brazil. Science , this issue p. [1255][1] Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country. [1]: /lookup/doi/10.1126/science.abd2161
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：278[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/293277
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Darlan S. Candido,Ingra M. Claro,Jaqueline G. de Jesus,et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil[J]. Science,2020.
APA	Darlan S. Candido.,Ingra M. Claro.,Jaqueline G. de Jesus.,William M. Souza.,Filipe R. R. Moreira.,...&Nuno Rodrigues Faria.(2020).Evolution and epidemic spread of SARS-CoV-2 in Brazil.Science.
MLA	Darlan S. Candido,et al."Evolution and epidemic spread of SARS-CoV-2 in Brazil".Science (2020).