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Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms 期刊论文
NATURE, 2020, 579 (7800) : 603-+
作者:  Xu, Wanghuai;  Zheng, Huanxi;  Liu, Yuan;  Zhou, Xiaofeng;  Zhang, Chao;  Song, Yuxin;  Deng, Xu;  Leung, Michael;  Yang, Zhengbao;  Xu, Ronald X.;  Wang, Zhong Lin;  Zeng, Xiao Cheng;  Wang, Zuankai
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption(1). Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers(1,2). Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi anaemia (FA), a disease resulting in failure to produce blood cells and a predisposition to cancer(3,4). The combined inactivation of acetaldehyde detoxification and the FA pathway induces mutation, accelerates malignancies and causes the rapid attrition of blood stem cells(5-7). However, the nature of the DNA damage induced by acetaldehyde and how this is repaired remains a key question. Here we generate acetaldehyde-induced DNA interstrand crosslinks and determine their repair mechanism in Xenopus egg extracts. We find that two replication-coupled pathways repair these lesions. The first is the FA pathway, which operates using excision-analogous to the mechanism used to repair the interstrand crosslinks caused by the chemotherapeutic agent cisplatin. However, the repair of acetaldehyde-induced crosslinks results in increased mutation frequency and an altered mutational spectrum compared with the repair of cisplatin-induced crosslinks. The second repair mechanism requires replication fork convergence, but does not involve DNA incisions-instead the acetaldehyde crosslink itself is broken. The Y-family DNA polymerase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum. These results define the repair pathways of DNA interstrand crosslinks caused by an endogenous and alcohol-derived metabolite, and identify an excision-independent mechanism.


DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.


  
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
The global warming hiatus has faded away: An analysis of 2014-2016 global surface air temperatures 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (12) : 4853-4868
作者:  Zhang, Chao;  Li, Shuanglin;  Luo, Feifei;  Huang, Zhen
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
global annual surface temperature  record warming in recent years  timescale separation  warming hiatus  
Influence of cumulus convection schemes on winter North Pacific storm tracks in the regional climate model RegCM4.5 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Yang, Minghao;  Tan, Yanke;  Li, Xin;  Chen, Xiong;  Zhang, Chao;  Yu, Peilong
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
baroclinic energy conversion  cumulus convection scheme  interannual variation  regional climate model  storm track  storm track index  
Impacts of Tropical Indian and Atlantic Ocean Warming on the Occurrence of the 2017/2018 La Nina 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (6) : 3435-3445
作者:  Zhang, Chao;  Luo, Jing-Jia;  Li, Shuanglin
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/26
the 2017  2018 La Nina  the long-lasting La Nina  the tropical Indian and Atlantic Ocean warming  
Quantifying hot carrier and thermal contributions in plasmonic photocatalysis 期刊论文
SCIENCE, 2018, 362 (6410) : 69-+
作者:  Zhou, Linan;  Swearer, Dayne F.;  Zhang, Chao;  Robatjazi, Hossein;  Zhao, Hangqi;  Henderson, Luke;  Dong, Liangliang;  Christopher, Phillip;  Carter, Emily A.;  Nordlander, Peter;  Halas, Naomi J.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Lowest matric potential in quartz: Metadynamics evidence 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (4)
作者:  Zhang, Chao;  Dong, Yi;  Liu, Zhen
收藏  |  浏览/下载:0/0  |  提交时间:2019/04/09