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Global roll-out of comprehensive policy measures may aid in bridging emissions gap 期刊论文
Nature Communications, 2021
作者:  van Soest, Heleen L.;  Aleluia Reis, Lara;  Baptista, Luiz Bernardo;  Bertram, Christoph;  Despré;  s, Jacques;  Drouet, Laurent;  den Elzen, Michel;  Fragkos, Panagiotis;  Fricko, Oliver;  Fujimori, Shinichiro;  Grant, Neil;  Harmsen, Mathijs;  Iyer, Gokul;  Keramidas, Kimon;  ;  berle, Alexandre C.;  Kriegler, Elmar;  Malik, Aman;  Mittal, Shivika;  Oshiro, Ken;  Riahi, Keywan;  Roelfsema, Mark;  van Ruijven, Bas;  Schaeffer, Roberto;  Silva Herran, Diego;  Tavoni, Massimo;  Unlu, Gamze;  Vandyck, Toon;  van Vuuren, Detlef P.
收藏  |  浏览/下载:14/0  |  提交时间:2021/11/15
Reply to "High energy and materials requirement for direct air capture calls for further analysis and R&D" 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Realmonte, Giulia;  Drouet, Laurent;  Gambhir, Ajay;  Glynn, James;  Hawkes, Adam;  Koberle, Alexandre C.;  Tavoni, Massimo
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/06
Stress- and ubiquitylation-dependent phase separation of the proteasome 期刊论文
NATURE, 2020, 578 (7794) : 296-+
作者:  Jewell, Jessica;  Emmerling, Johannes;  Vinichenko, Vadim;  Bertram, Christoph;  Berger, Loic;  Daly, Hannah E.;  Keppo, Ilkka;  Krey, Volker;  Gernaat, David E. H. J.;  Fragkiadakis, Kostas;  McCollum, David;  Paroussas, Leonidas;  Riahi, Keywan;  Tavoni, Massimo;  van Vuuren, Detlef
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins(1,2). A number of ubiquitin-related molecules have recently been found to be involved in the regulation of biomolecular condensates or membraneless organelles, which arise by liquid-liquid phase separation of specific biomolecules, including stress granules, nuclear speckles and autophagosomes(3-8), but it remains unclear whether the proteasome also participates in such regulation. Here we reveal that proteasome-containing nuclear foci form under acute hyperosmotic stress. These foci are transient structures that contain ubiquitylated proteins, p97 (also known as valosin-containing protein (VCP)) and multiple proteasome-interacting proteins, which collectively constitute a proteolytic centre. The major substrates for degradation by these foci were ribosomal proteins that failed to properly assemble. Notably, the proteasome foci exhibited properties of liquid droplets. RAD23B, a substrate-shuttling factor for the proteasome, and ubiquitylated proteins were necessary for formation of proteasome foci. In mechanistic terms, a liquid-liquid phase separation was triggered by multivalent interactions of two ubiquitin-associated domains of RAD23B and ubiquitin chains consisting of four or more ubiquitin molecules. Collectively, our results suggest that ubiquitin-chain-dependent phase separation induces the formation of a nuclear proteolytic compartment that promotes proteasomal degradation.


Hyperosmotic stress leads to a phase separation of the proteasome, triggered by interactions between RAD23B and ubiquitylated proteins, which bring together p97 and proteasome-associated proteins into nuclear proteolytic foci.


  
The public costs of climate-induced financial instability 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (11) : 829-+
作者:  Lamperti, Francesco;  Bosetti, Valentina;  Roventini, Andrea;  Tavoni, Massimo
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Connecting climate action with other Sustainable Development Goals 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (8) : 674-680
作者:  Nerini, Francesco Fuso;  Sovacool, Benjamin;  Hughes, Nick;  Cozzi, Laura;  Cosgrave, Ellie;  Howells, Mark;  Tavoni, Massimo;  Tomei, Julia;  Zerriffi, Hisham;  Milligan, Ben
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/19
Country-level social cost of carbon (vol 8, pg 895, 2018) 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (7) : 567-567
作者:  Ricke, Katharine;  Drouet, Laurent;  Caldeira, Ken;  Tavoni, Massimo
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Exploration of the interactions between mitigation and solar radiation management in cooperative and non-cooperative international governance settings 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2018, 53: 244-251
作者:  Emmerling, Johannes;  Tavoni, Massimo
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Mitigation scenarios must cater to new users 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (10) : 845-848
作者:  Weber, Christopher;  McCollum, David L.;  Edmonds, Jae;  Faria, Pedro;  Pyanet, Alban;  Rogelj, Joeri;  Tavoni, Massimo;  Thoma, Jakob;  Kriegler, Elmar
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Country-level social cost of carbon 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (10) : 895-+
作者:  Ricke, Katharine;  Drouet, Laurent;  Caldeira, Ken;  Tavoni, Massimo
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Residual fossil CO2 emissions in 1.5-2 degrees C pathways 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (7) : 626-+
作者:  Luderer, Gunnar;  Vrontisi, Zoi;  Bertram, Christoph;  Edelenbosch, Oreane Y.;  Pietzcker, Robert C.;  Rogelj, Joeri;  De Boer, Harmen Sytze;  Drouet, Laurent;  Emmerling, Johannes;  Fricko, Oliver;  Fujimori, Shinichiro;  Havlik, Petr;  Iyer, Gokul;  Keramidas, Kimon;  Kitous, Alban;  Pehl, Michaja;  Krey, Volker;  Riahi, Keywan;  Saveyn, Bert;  Tavoni, Massimo;  Van Vuuren, Detlef P.;  Kriegler, Elmar
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09