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Decadal changes in anthropogenic source contribution of PM2.5 pollution and related health impacts in China, 1990-2015 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7783-7799
作者:  Liu, Jun;  Zheng, Yixuan;  Geng, Guannan;  Hong, Chaopeng;  Li, Meng;  Li, Xin;  Liu, Fei;  Tong, Dan;  Wu, Ruili;  Zheng, Bo;  He, Kebin;  Zhang, Qiang
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06
Sm-Nd isochron dating and geochemical (rare earth elements, Sr-87/Sr-86, delta O-18, delta C-13) characterization of calcite veins in the Jiaoshiba shale gas field, China: Implications for the mechanisms of vein formation in shale gas systems 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1722-1740
作者:  Gao, Jian;  He, Sheng;  Zhao, Jian-xin;  He, Zhiliang;  Wu, Changwu;  Fen, Yuexing;  Ai Duc Nguyen;  Zhou, Jiaxi;  Yi, Zhixing
收藏  |  浏览/下载:12/0  |  提交时间:2020/08/18
The Stove, Dome, and Umbrella Effects of Atmospheric Aerosol on the Development of the Planetary Boundary Layer in Hazy Regions 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Ma, Yongjing;  Ye, Jianhuai;  Xin, Jinyuan;  Zhang, Wenyu;  de Arellano, Jordi Vila-Guerau;  Wang, Shigong;  Zhao, Dandan;  Dai, Lindong;  Ma, Yongxiang;  Wu, Xiaoyan;  Xia, Xiangao;  Tang, Guiqian;  Wang, Yuesi;  Shen, Pengke;  Lei, Yali;  Martin, Scot T.
收藏  |  浏览/下载:15/0  |  提交时间:2020/06/22
Particle-in-Cell Simulation of Electron Cyclotron Harmonic Waves Driven by a Loss Cone Distribution 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Wu, Yifan;  Tao, Xin;  Liu, Xu;  Chen, Lunjin;  Xie, Huasheng;  Liu, Kaijun;  Horne, Richard B.
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
ECH waves  PIC simulation  magnetosphere  electrostatic wave  loss cone distribution  
Effects of Nonlinear Resonance Broadening on Interactions Between Electrons and Whistler Mode Waves 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Cai, Bin;  Wu, Yifan;  Tao, Xin
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/13
nonlinear diffusion  whistler waves  radiation belts  test particle simulation  
LA-MC-ICP-MS U-Pb dating of low-U garnets reveals multiple episodes of skarn formation in the volcanic-hosted iron mineralization system, Awulale belt, Central Asia 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1031-1045
作者:  Yan, Shuang;  Zhou, Renjie;  Niu, He-Cai;  Feng, Yue-xing;  Ai Duc Nguyen;  Zhao, Zhen-hua;  Yang, Wu-Bin;  Dong, Qian;  Zhao, Jian-xin
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/02
LA-MC-ICP-MS U-Pb dating of low-U garnets reveals multiple episodes of skarn formation in the volcanic-hosted iron mineralization system, Awulale belt, Central Asia (vol 132, pg 1031, 2020) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1046-1046
作者:  Yan, Shuang;  Zhou, Renjie;  Niu, He-Cai;  Feng, Yue-xing;  Ai Duc Nguyen;  Zhao, Zhen-hua;  Yang, Wu-Bin;  Dong, Qian;  Zhao, Jian-xin
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/02
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
A neurotransmitter produced by gut bacteria modulates host sensory behaviour 期刊论文
NATURE, 2020
作者:  Zhao, Xiaoxu;  Song, Peng;  Wang, Chengcai;  Riis-Jensen, Anders C.;  Fu, Wei;  Deng, Ya;  Wan, Dongyang;  Kang, Lixing;  Ning, Shoucong;  Dan, Jiadong;  Venkatesan, T.;  Liu, Zheng;  Zhou, Wu;  Thygesen, Kristian S.;  Luo, Xin;  Pennycook, Stephen J.;  Loh, Kian Ping
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

A neuromodulator produced by commensalProvidenciabacteria that colonize the gut ofCaenorhabditis elegansmimics the functions of the cognate host molecule to manipulate a sensory decision of the host.


Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities of diverse organisms, including microorganisms(1). Some bacteria produce bioactive neurotransmitters that have previously been proposed to modulate nervous system activity and behaviours of their hosts(2,3). However, the mechanistic basis of this microbiota-brain signalling and its physiological relevance are largely unknown. Here we show that inCaenorhabditis elegans, the neuromodulator tyramine produced by commensalProvidenciabacteria, which colonize the gut, bypasses the requirement for host tyramine biosynthesis and manipulates a host sensory decision. Bacterially produced tyramine is probably converted to octopamine by the host tyramine beta-hydroxylase enzyme. Octopamine, in turn, targets the OCTR-1 octopamine receptor on ASH nociceptive neurons to modulate an aversive olfactory response. We identify the genes that are required for tyramine biosynthesis inProvidencia, and show that these genes are necessary for the modulation of host behaviour. We further find thatC. eleganscolonized byProvidenciapreferentially select these bacteria in food choice assays, and that this selection bias requires bacterially produced tyramine and host octopamine signalling. Our results demonstrate that a neurotransmitter produced by gut bacteria mimics the functions of the cognate host molecule to override host control of a sensory decision, and thereby promotes fitness of both the host and the microorganism.


  
Haze pollution under a high atmospheric oxidization capacity in summer in Beijing: insights into formation mechanism of atmospheric physicochemical processes 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 4575-4592
作者:  Zhao, Dandan;  Liu, Guangjing;  Xin, Jinyuan;  Quan, Jiannong;  Wang, Yuesi;  Wang, Xin;  Dai, Lindong;  Gao, Wenkang;  Tang, Guiqian;  Hu, Bo;  Ma, Yongxiang;  Wu, Xiaoyan;  Wang, Lili;  Liu, Zirui;  Wu, Fangkun
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/13