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Strong sensitivity of the isotopic composition of methane to the plausible range of tropospheric chlorine 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (14) : 8405-8419
作者:  Strode, Sarah A.;  Wang, James S.;  Manyin, Michael;  Duncan, Bryan;  Hossaini, Ryan;  Keller, Christoph A.;  Michel, Sylvia E.;  White, James W. C.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/21
Breaking Earth's shell into a global plate network 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tang, C. A.;  Webb, A. A. G.;  Moore, W. B.;  Wang, Y. Y.;  Ma, T. H.;  Chen, T. T.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/21
Microphysical Properties of Generating Cells Over the Southern Ocean: Results From SOCRATES 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Wang, Yang;  McFarquhar, Greg M.;  Rauber, Robert M.;  Zhao, Chuanfeng;  Wu, Wei;  Finlon, Joseph A.;  Stechman, Daniel M.;  Stith, Jeffery;  Jensen, Jorgen B.;  Schnaiter, Martin;  Jarvinen, Emma;  Waitz, Fritz;  Vivekanandan, Jothiram;  Dixon, Michael;  Rainwater, Bryan;  Toohey, Darin W.
收藏  |  浏览/下载:28/0  |  提交时间:2020/08/18
generating cells  microphysical properties  Southern Ocean  
Erythemal Radiation, Column Ozone, and the North American Monsoon 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Schoeberl, M. R.;  Pfister, L.;  Wang, T.;  Kummer, J.;  Dessler, A. E.;  Yu, W.
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/18
erythemal  convection  monsoon  
Constraining remote oxidation capacity with ATom observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7753-7781
作者:  Travis, Katherine R.;  Heald, Colette L.;  Allen, Hannah M.;  Apel, Eric C.;  Arnold, Stephen R.;  Blake, Donald R.;  Brune, William H.;  Chen, Xin;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  Elkins, James W.;  Evans, Mathew J.;  Hall, Samuel R.;  Hintsa, Eric J.;  Hornbrook, Rebecca S.;  Kasibhatla, Prasad S.;  Kim, Michelle J.;  Luo, Gan;  McKain, Kathryn;  Millet, Dylan B.;  Moore, Fred L.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  Sherwen, Tomas;  Thames, Alexander B.;  Ullmann, Kirk;  Wang, Xuan;  Wennberg, Paul O.;  Wolfe, Glenn M.;  Yu, Fangqun
收藏  |  浏览/下载:48/0  |  提交时间:2020/08/18
Biofuel burning and human respiration bias on satellite estimates of fossil fuel CO(2)emissions 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Ciais, P.;  Wang, Y.;  Andrew, R.;  Breon, F. M.;  Chevallier, F.;  Broquet, G.;  Nabuurs, G. J.;  Peters, G.;  McGrath, M.;  Meng, W.;  Zheng, B.;  Tao, S.
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
fossil fuel emissions  satellites  biofuels  
Revealing enigmatic mucus structures in the deep sea using DeepPIV 期刊论文
NATURE, 2020, 583 (7814) : 78-+
作者:  Nguyen, Ngoc Uyen Nhi;  Canseco, Diana C.;  Xiao, Feng;  Nakada, Yuji;  Li, Shujuan;  Lam, Nicholas T.;  Muralidhar, Shalini A.;  Savla, Jainy J.;  Hill, Joseph A.;  Le, Victor;  Zidan, Kareem A.;  El-Feky, Hamed W.;  Wang, Zhaoning;  Ahmed, Mahmoud Salama;  Hubbi, Maimon E.;  Menendez-Montes, Ivan
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09

Advanced deep-sea imaging tools yield insights into the structure and function of mucus filtration houses built by midwater giant larvaceans.


Many animals build complex structures to aid in their survival, but very few are built exclusively from materials that animals create (1,2). In the midwaters of the ocean, mucoid structures are readily secreted by numerous animals, and serve many vital functions(3,4). However, little is known about these mucoid structures owing to the challenges of observing them in the deep sea. Among these mucoid forms, the '  houses'  of larvaceans are marvels of nature(5), and in the ocean twilight zone giant larvaceans secrete and build mucus filtering structures that can reach diameters of more than 1 m(6). Here we describe in situ laser-imaging technology(7) that reconstructs three-dimensional models of mucus forms. The models provide high-resolution views of giant larvacean houses and elucidate the role that house structure has in food capture and predator avoidance. Now that tools exist to study mucus structures found throughout the ocean, we can shed light on some of nature'  s most complex forms.


  
Extending the Global Mass Change Data Record: GRACE Follow-On Instrument and Science Data Performance 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Landerer, Felix W.;  Flechtner, Frank M.;  Save, Himanshu;  Webb, Frank H.;  Bandikova, Tamara;  Bertiger, William, I;  Bettadpur, Srinivas, V;  Byun, Sung Hun;  Dahle, Christoph;  Dobslaw, Henryk;  Fahnestock, Eugene;  Harvey, Nate;  Kang, Zhigui;  Kruizinga, Gerhard L. H.;  Loomis, Bryant D.;  McCullough, Christopher;  Murboeck, Michael;  Nagel, Peter;  Paik, Meegyeong;  Pie, Nadege;  Poole, Steve;  Strekalov, Dmitry;  Tamisiea, Mark E.;  Wang, Furun;  Watkins, Michael M.;  Wen, Hui-Ying;  Wiese, David N.;  Yuan, Dah-Ning
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/25
GRACE-FO  satellite gravimetry  mass change  hydrogeodesy  ice melt  mass transport  
Improvement in municipal wastewater treatment alters lake nitrogen to phosphorus ratios in populated regions 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (21) : 11566-11572
作者:  Tong, Yindong;  Wang, Mengzhu;  Penuelas, Josep;  Liu, Xueyan;  Paerl, Hans W.;  Elser, James J.;  Sardans, Jordi;  Couture, Raoul-Marie;  Larssen, Thorjorn;  Hu, Hongying;  Dong, Xin;  He, Wei;  Zhang, Wei;  Wang, Xuejun;  Zhang, Yang;  Liu, Yi;  Zeng, Siyu;  Kong, Xiangzhen;  Janssen, Annette B. G.;  Lin, Yan
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
nutrient balance  water quality change  anthropogenic source  wastewater treatment  aquatic ecosystem  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.