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Multiple transpolar auroral arcs reveal insight about coupling processes in the Earth's magnetotail 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (28) : 16193-16198
作者:  Zhang, Qing-He;  Zhang, Yong-Liang;  Wang, Chi;  Lockwood, Michael;  Yang, Hui-Gen;  Tang, Bin-Bin;  Xing, Zan-Yang;  Oksavik, Kjellmar;  Lyons, Larry R.;  Ma, Yu-Zhang;  Zong, Qiu-Gang;  Moen, Joran Idar;  Xia, Li-Dong
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/06
aurora  solar-terrestrial interaction  magnetosphere  polar ionosphere  transpolar auroral arcs  
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Qiu, Fang;  Tang, Ruqi;  Zuo, Xianbo;  Shi, Xingjuan;  Wei, Yiran;  Zheng, Xiaodong;  Dai, Yaping;  Gong, Yuhua;  Wang, Lan;  Xu, Ping;  Zhu, Xiang;  Wu, Jian;  Han, Chongxu;  Gao, Yueqiu;  Zhang, Kui;  Jiang, Yuzhang;  Zhou, Jianbo;  Shao, Youlin;  Hu, Zhigang;  Tian, Ye;  Zhang, Haiyan;  Dai, Na;  Liu, Lei;  Wu, Xudong;  Zhao, Weifeng;  Zhang, Xiaomin;  Zang, Zhidong;  Nie, Jinshan;  Sun, Weihao;  Zhao, Yi;  Mao, Yuan;  Jiang, Po;  Ji, Hualiang;  Dong, Qing;  Li, Junming;  Li, Zhenzhong;  Bai, Xinli;  Li, Li;  Lin, Maosong;  Dong, Ming;  Li, Jinxin;  Zhu, Ping;  Wang, Chan;  Zhang, Yanqiu;  Jiang, Peng;  Wang, Yujue;  Jawed, Rohil;  Xu, Jing;  Zhang, Yu;  Wang, Qixia;  Yang, Yue;  Yang, Fan;  Lian, Min;  Jiang, Xiang;  Xiao, Xiao;  Li, Yanmei;  Fang, Jingyuan;  Qiu, Dekai;  Zhu, Zhen;  Qiu, Hong;  Zhang, Jianqiong;  Tian, Wenyan;  Chen, Sufang;  Jiang, Ling;  Ji, Bing;  Li, Ping;  Chen, Guochang;  Wu, Tianxue;  Sun, Yan;  Yu, Jianjiang;  Tang, Huijun;  He, Michun;  Xia, Min;  Pei, Hao;  Huang, Lihua;  Qing, Zhuye;  Wu, Jianfang;  Huang, Qinghai;  Han, Junhai;  Xie, Wei;  Sun, Zhongsheng;  Guo, Jian;  He, Gengsheng;  Gershwin, M. Eric;  Lian, Zhexiong;  Liu, Xiang;  Seldin, Michael F.;  Liu, Xiangdong;  Chen, Weichang;  Ma, Xiong
收藏  |  浏览/下载：18/0  |  提交时间：2019/11/27
The gut microbiome in atherosclerotic cardiovascular disease 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jie, Zhuye;  Xia, Huihua;  Zhong, Shi-Long;  Feng, Qiang;  Li, Shenghui;  Liang, Suisha;  Zhong, Huanzi;  Liu, Zhipeng;  Gao, Yuan;  Zhao, Hui;  Zhang, Dongya;  Su, Zheng;  Fang, Zhiwei;  Lan, Zhou;  Li, Junhua;  Xiao, Liang;  Li, Jun;  Li, Ruijun;  Li, Xiaoping;  Li, Fei;  Ren, Huahui;  Huang, Yan;  Peng, Yangqing;  Li, Guanglei;  Wen, Bo;  Dong, Bo;  Chen, Ji-Yan;  Geng, Qing-Shan;  Zhang, Zhi-Wei;  Yang, Huanming;  Wang, Jian;  Wang, Jun;  Zhang, Xuan;  Madsen, Lise;  Brix, Susanne;  Ning, Guang;  Xu, Xun;  Liu, Xin;  Hou, Yong;  Jia, Huijue;  He, Kunlun;  Kristiansen, Karsten
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Xia, Qing;  Chen, Zixuan;  Xiao, Pengwei;  Wang, Minxuan;  Chen, Xueqin;  Zhang, Jian-Rong;  Chen, Hong-Yuan;  Zhu, Jun-Jie
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Lian, Huan;  Wei, Jin;  Zang, Ru;  Ye, Wen;  Yang, Qing;  Zhang, Xia-Nan;  Chen, Yun-Da;  Fu, Yu-Zhi;  Hu, Ming-Ming;  Lei, Cao-Qi;  Luo, Wei-Wei;  Li, Shu;  Shu, Hong-Bing
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
Drought tolerance traits predict survival ratio of native tree species planted in a subtropical degraded hilly area in South China 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 418: 41-46
作者:  Zhu, Shi-Dan;  He, Peng-Cheng;  Li, Rong-Hua;  Fu, Sheng-Lei;  Lin, Yong-Biao;  Zhou, Li-Xia;  Cao, Kun-Fang;  Ye, Qing
收藏  |  浏览/下载：9/0  |  提交时间：2019/04/09
Cavitation  Forest restoration  Hydraulic conductivity  Hydraulic safety margin  Survival  Turgor loss point  
Chiral Majorana fermion modes in a quantum anomalous Hall insulator-superconductor structure 期刊论文
SCIENCE, 2017, 357 (6348) : 294-299
作者:  He, Qing Lin;  Pan, Lei;  Stern, Alexander L.;  Burks, Edward C.;  Che, Xiaoyu;  Yin, Gen;  Wang, Jing;  Lian, Biao;  Zhou, Quan;  Choi, Eun Sang;  Murata, Koichi;  Kou, Xufeng;  Chen, Zhijie;  Nie, Tianxiao;  Shao, Qiming;  Fan, Yabin;  Zhang, Shou-Cheng;  Liu, Kai;  Xia, Jing;  Wang, Kang L.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Bug mapping and fitness testing of chemically synthesized chromosome X 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Wu, Yi;  Li, Bing-Zhi;  Zhao, Meng;  Mitchell, Leslie A.;  Xie, Ze-Xiong;  Lin, Qiu-Hui;  Wang, Xia;  Xiao, Wen-Hai;  Wang, Ying;  Zhou, Xiao;  Liu, Hong;  Li, Xia;  Ding, Ming-Zhu;  Liu, Duo;  Zhang, Lu;  Liu, Bao-Li;  Wu, Xiao-Le;  Li, Fei-Fei;  Dong, Xiu-Tao;  Jia, Bin;  Zhang, Wen-Zheng;  Jiang, Guo-Zhen;  Liu, Yue;  Bai, Xue;  Song, Tian-Qing;  Chen, Yan;  Zhou, Si-Jie;  Zhu, Rui-Ying;  Gao, Feng;  Kuang, Zheng;  Wang, Xuya;  Shen, Michael;  Yang, Kun;  Stracquadanio, Giovanni;  Richardson, Sarah M.;  Lin, Yicong;  Wang, Lihui;  Walker, Roy;  Luo, Yisha;  Ma, Ping-Sheng;  Yang, Huanming;  Cai, Yizhi;  Dai, Junbiao;  Bader, Joel S.;  Boeke, Jef D.;  Yuan, Ying-Jin
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27