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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Plasticity in elk migration timing is a response to changing environmental conditions 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (7) : 2368-2381
作者:  Rickbeil, Gregory J. M.;  Merkle, Jerod A.;  Anderson, Greg;  Atwood, M. Paul;  Beckmann, Jon P.;  Cole, Eric K.;  Courtemanch, Alyson B.;  Dewey, Sarah;  Gustine, David D.;  Kauffman, Matthew J.;  McWhirter, Douglas E.;  Mong, Tony;  Proffitt, Kelly;  White, Patrick J.;  Middleton, Arthur D.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
climate change  forage  GPS  phenology  range  snow  telemetry  ungulate  Yellowstone  
The 2018 rift eruption and summit collapse of Kilauea Volcano 期刊论文
SCIENCE, 2019, 363 (6425) : 367-+
作者:  Neal, C. A.;  Brantley, S. R.;  Antolik, L.;  Babb, J. L.;  Burgess, M.;  Calles, K.;  Cappos, M.;  Chang, J. C.;  Conway, S.;  Desmither, L.;  Dotray, P.;  Elias, T.;  Fukunaga, P.;  Fuke, S.;  Johanson, I. A.;  Kamibayashi, K.;  kauahikaua, J.;  Lee, R. L.;  Pekalib, S.;  Miklius, A.;  Million, W.;  Moniz, C. J.;  Nadeau, P. A.;  Okubo, P.;  Parcheta, C.;  Patrick, M. R.;  Shiro, B.;  Swanson, D. A.;  Tollett, W.;  Trusdell, F.;  Younger, E. F.;  Zoeller, M. H.;  Montgomery-Brown, E. K.;  Anderson, K. R.;  Poland, M. P.;  Ball, J. L.;  Bard, J.;  Coombs, M.;  Dietterich, H. R.;  Kern, C.;  Thelen, W. A.;  Cervelli, P. F.;  Orr, T.;  Houghton, B. F.;  Ganseddi, C.;  Hazlett, R.;  Lundgren, P.;  Diefenbach, A. K.;  Lerner, A. H.;  Waite, G.;  Kelly, P.;  Clors, L.;  Werner, C.;  Mulliken, K.;  Fisher, G.;  Damby, D.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Soil erosion in East Africa: an interdisciplinary approach to realising pastoral land management change 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (12)
作者:  Blake, William H.;  Rabinovich, Anna;  Wynants, Maarten;  Kelly, Claire;  Nasseri, Mona;  Ngondya, Issakwisa;  Patrick, Aloyce;  Mtei, Kelvin;  Munishi, Linus;  Boeckx, Pascal;  Navas, Ana;  Smith, Hugh G.;  Gilvear, David;  Wilson, Geoff;  Roberts, Neil;  Ndakidemi, Patrick
收藏  |  浏览/下载：13/0  |  提交时间：2019/04/09
global challenges  land degradation  co-design  sustainable land management  water-food-energy nexus  resilience  Jali Ardhi  
Shape of Atlantic Tropical Cyclone Tracks and the Indian Monsoon 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (19) : 10746-10755
作者:  Kelly, Patrick;  Leung, L. Ruby;  Balaguru, Karthik;  Xu, Wenwei;  Mapes, Brian;  Soden, Brian
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
Land ownership and 20th century changes to forest structure in California 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 422: 137-146
作者:  Easterday, Kelly;  Mclntyre, Patrick;  Kelly, Maggi
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
Forest structure  Forest change  Land management  Land ownership  California  Vegetation Type Mapping (VTM)  
Remote Drying in the North Atlantic as a Common Response to Precessional Changes and CO2 Increase Over Land 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (8) : 3615-3624
作者:  Kelly, Patrick;  Kravitz, Ben;  Lu, Jian;  Leung, L. Ruby
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/09
Glyoxal yield from isoprene oxidation and relation to formaldehyde: chemical mechanism, constraints from SENEX aircraft observations, and interpretation of OMI satellite data 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (14)
作者:  Miller, Christopher Chan;  Jacob, Daniel J.;  Marais, Eloise A.;  Yu, Karen;  Travis, Katherine R.;  Kim, Patrick S.;  Fisher, Jenny A.;  Zhu, Lei;  Wolfe, Glenn M.;  Hanisco, Thomas F.;  Keutsch, Frank N.;  Kaiser, Jennifer;  Min, Kyung-Eun;  Brown, Steven S.;  Washenfelder, Rebecca A.;  Abad, Gonzalo Gonzalez;  Chance, Kelly
收藏  |  浏览/下载：12/0  |  提交时间：2019/04/09