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Methylmercury produced in upper oceans accumulates in deep Mariana Trench fauna 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Sun, Ruoyu;  Yuan, Jingjing;  Sonke, Jeroen E.;  Zhang, Yanxu;  Zhang, Tong;  Zheng, Wang;  Chen, Shun;  Meng, Mei;  Chen, Jiubin;  Liu, Yi;  Peng, Xiaotong;  Liu, Congqiang
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/09
Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
Ligand-induced monoubiquitination of BIK1 regulates plant immunity 期刊论文
NATURE, 2020, 581 (7807) : 199-+
作者:  Shao, Wei;  Yang, Jiajun;  He, Ming;  Yu, Xiang-Yu;  Lee, Choong Heon;  Yang, Zhaohui;  Joyner, Alexandra L.;  Anderson, Kathryn V.;  Zhang, Jiangyang;  Tsou, Meng-Fu Bryan;  Shi, Hang;  Shi, Song-Hai
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens(1-3). Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants(4). The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.


  
Dualities and non-Abelian mechanics 期刊论文
NATURE, 2020, 577 (7792) : 636-+
作者:  Song, Xinyang;  Sun, Ximei;  Oh, Sungwhan F.;  Wu, Meng;  Zhang, Yanbo;  Zheng, Wen;  Geva-Zatorsky, Naama;  Jupp, Ray;  Mathis, Diane;  Benoist, Christophe;  Kasper, Dennis L.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Dualities-mathematical mappings between different systems-can act as hidden symmetries that enable materials design beyond that suggested by crystallographic space groups.


Dualities are mathematical mappings that reveal links between apparently unrelated systems in virtually every branch of physics(1-8). Systems mapped onto themselves by a duality transformation are called self-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet at the critical point. Here we show how dualities can enhance the symmetries of a dynamical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that escape a standard group theory analysis. As an illustration, we consider twisted kagome lattices(9-15), reconfigurable mechanical structures that change shape by means of a collapse mechanism(9). We observe that pairs of distinct configurations along the mechanism exhibit the same vibrational spectrum and related elastic moduli. We show that these puzzling properties arise from a duality between pairs of configurations on either side of a mechanical critical point. The critical point corresponds to a self-dual structure with isotropic elasticity even in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zone. The spectral degeneracy originates from a version of Kramers'  theorem(16,17) in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-dual point. The normal modes of the self-dual systems exhibit non-Abelian geometric phases(18,19) that affect the semiclassical propagation of wavepackets(20), leading to non-commuting mechanical responses. Our results hold promise for holonomic computation(21) and mechanical spintronics by allowing on-the-fly manipulation of synthetic spins carried by phonons.


  
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
CXCR1-or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Jin, Linchun;  Tao, Haipeng;  Karachi, Aida;  Long, Yu;  Hou, Alicia Y.;  Na, Meng;  Dyson, Kyle A.;  Grippin, Adam J.;  Deleyrolle, Loic P.;  Zhang, Wang;  Rajon, Didier A.;  Wang, Qiong J.;  Yang, James C.;  Kresak, Jesse L.;  Sayour, Elias J.;  Rahman, Maryam;  Bova, Frank J.;  Lin, Zhiguo;  Mitchell, Duane A.;  Huang, Jianping
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Ultrahigh-energy density lead-free dielectric films via polymorphic nanodomain design 期刊论文
SCIENCE, 2019, 365 (6453) : 578-582
作者:  Pan, Hao;  Li, Fei;  Liu, Yao;  Zhang, Qinghua;  Wang, Meng;  Lan, Shun;  Zheng, Yunpeng;  Ma, Jing;  Gu, Lin;  Shen, Yang;  Yu, Pu;  Zhang, Shujun;  Chen, Long-Qing;  Lin, Yuan-Hua;  Nan, Ce-Wen
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Intragranular cracking as a critical barrier for high-voltage usage of layer-structured cathode for lithium-ion batteries 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yan, Pengfei;  Zheng, Jianming;  Gu, Meng;  Xiao, Jie;  Zhang, Ji-Guang;  Wang, Chong-Min
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Selective light absorber-assisted single nickel atom catalysts for ambient sunlight-driven CO2 methanation 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Li, Yaguang;  Hao, Jianchao;  Song, Hui;  Zhang, Fengyu;  Bai, Xianhua;  Meng, Xianguang;  Zhang, Hongyuan;  Wang, Shufang;  Hu, Yong;  Ye, Jinhua
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Long-term functional maintenance of primary human hepatocytes in vitro 期刊论文
SCIENCE, 2019, 364 (6438) : 399-+
作者:  Xiang, Chengang;  Du, Yuanyuan;  Meng, Gaofan;  Yi, Liew Soon;  Sun, Shicheng;  Song, Nan;  Zhang, Xiaonan;  Xiao, Yiwei;  Wang, Jie;  Yi, Zhigang;  Liu, Yifang;  Xie, Bingqing;  Wu, Min;  Shu, Jun;  Sun, Da;  Jia, Jun;  Liang, Zhen;  Sun, Dong;  Huang, Yanxiang;  Shi, Yan;  Xu, Jun;  Lu, Fengmin;  Li, Cheng;  Xiang, Kuanhui;  Yuan, Zhenghong;  Lu, Shichun;  Deng, Hongkui
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27