GSTDTAP

浏览/检索结果: 共26条,第1-10条 帮助

限定条件        
已选(0)清除 条数/页:   排序方式:
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells 期刊论文
SCIENCE, 2019, 366 (6467) : 850-+
作者:  Tian, Xinlong;  Zhao, Xiao;  Su, Ya-Qiong;  Wang, Lijuan;  Wang, Hongming;  Dang, Dai;  Chi, Bin;  Liu, Hongfang;  Hensen, Emiel J. M.;  Lou, Xiong Wen (David);  Xia, Bao Yu
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Qiu, Fang;  Tang, Ruqi;  Zuo, Xianbo;  Shi, Xingjuan;  Wei, Yiran;  Zheng, Xiaodong;  Dai, Yaping;  Gong, Yuhua;  Wang, Lan;  Xu, Ping;  Zhu, Xiang;  Wu, Jian;  Han, Chongxu;  Gao, Yueqiu;  Zhang, Kui;  Jiang, Yuzhang;  Zhou, Jianbo;  Shao, Youlin;  Hu, Zhigang;  Tian, Ye;  Zhang, Haiyan;  Dai, Na;  Liu, Lei;  Wu, Xudong;  Zhao, Weifeng;  Zhang, Xiaomin;  Zang, Zhidong;  Nie, Jinshan;  Sun, Weihao;  Zhao, Yi;  Mao, Yuan;  Jiang, Po;  Ji, Hualiang;  Dong, Qing;  Li, Junming;  Li, Zhenzhong;  Bai, Xinli;  Li, Li;  Lin, Maosong;  Dong, Ming;  Li, Jinxin;  Zhu, Ping;  Wang, Chan;  Zhang, Yanqiu;  Jiang, Peng;  Wang, Yujue;  Jawed, Rohil;  Xu, Jing;  Zhang, Yu;  Wang, Qixia;  Yang, Yue;  Yang, Fan;  Lian, Min;  Jiang, Xiang;  Xiao, Xiao;  Li, Yanmei;  Fang, Jingyuan;  Qiu, Dekai;  Zhu, Zhen;  Qiu, Hong;  Zhang, Jianqiong;  Tian, Wenyan;  Chen, Sufang;  Jiang, Ling;  Ji, Bing;  Li, Ping;  Chen, Guochang;  Wu, Tianxue;  Sun, Yan;  Yu, Jianjiang;  Tang, Huijun;  He, Michun;  Xia, Min;  Pei, Hao;  Huang, Lihua;  Qing, Zhuye;  Wu, Jianfang;  Huang, Qinghai;  Han, Junhai;  Xie, Wei;  Sun, Zhongsheng;  Guo, Jian;  He, Gengsheng;  Gershwin, M. Eric;  Lian, Zhexiong;  Liu, Xiang;  Seldin, Michael F.;  Liu, Xiangdong;  Chen, Weichang;  Ma, Xiong
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Aerosol pH Dynamics During Haze Periods in an Urban Environment in China: Use of Detailed, Hourly, Speciated Observations to Study the Role of Ammonia Availability and Secondary Aerosol Formation and Urban Environment 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (16) : 9730-9742
作者:  Shi, Guoliang;  Xu, Jiao;  Shi, Xurong;  Liu, Baoshuang;  Bi, Xiaohui;  Xiao, Zhimei;  Chen, Kui;  Wen, Jie;  Dong, Shihao;  Tian, Yingze;  Feng, Yinchang;  Yu, Haofei;  Song, Shaojie;  Zhao, Qianyu;  Gao, Jie;  Russell, Armistead G.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
aerosol  pH  ammonia  source  secondary aerosol  
Regulatory mechanism design of GHG emissions in the electric power industry in China 期刊论文
ENERGY POLICY, 2019, 131: 187-201
作者:  Feng, Tian-tian;  Gong, Xiao-lei;  Guo, Yu-hua;  Yang, Yi-sheng;  Dong, Jun
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Electric power industry  Greenhouse gas emission  Regulatory mechanism  
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Li, Shang-Ze;  Shu, Qi-Peng;  Song, Yang;  Zhang, Hui-Hui;  Liu, Yi;  Jin, Bing-Xue;  Liuyu, Tian-Zi;  Li, Chao;  Huang, Xi-Chen;  Du, Run-Lei;  Song, Wei;  Zhong, Bo;  Zhang, Xiao-Dong
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Quantifying the developed and developing worlds' carbon reduction contributions to Northern Hemisphere cryosphere change 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (7) : 3231-3240
作者:  Yang, Shili;  Dong, Wenjie;  Chou, Jieming;  Dai, Tanlong;  Hong, Tao;  Xiao, Cunde;  Wei, Ting;  Tian, Di;  Ji, Dong
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
climate change  climate policy  earth system model  the cryosphere  
Carbon budgets of wetland ecosystems in China 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (6) : 2061-2076
作者:  Xiao, Derong;  Deng, Lei;  Kim, Dong-Gill;  Huang, Chunbo;  Tian, Kun
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
carbon emission  carbon sequestration  carbon stock  carbon uptake  climate  wetland  
Evaluation of MODIS and two reanalysis aerosol optical depth products over AERONET sites 期刊论文
ATMOSPHERIC RESEARCH, 2019, 220: 75-80
作者:  Shi, Hanyu;  Xiao, Zhiciiang;  Zhan, Xuchen;  Ma, Han;  Tian, Xiaodan
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
AERONET  AOD  Evaluation  MERRA  MODIS  
MiR-497 similar to 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1 alpha activity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yang, Mi;  Li, Chang-Jun;  Sun, Xi;  Guo, Qi;  Xiao, Ye;  Su, Tian;  Tu, Man-Li;  Peng, Hui;  Lu, Qiong;  Liu, Qing;  He, Hong-Bo;  Jiang, Tie-Jian;  Lei, Min-Xiang;  Wan, Mei;  Cao, Xu;  Luo, Xiang-Hang
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27