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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Torsional refrigeration by twisted, coiled, and supercoiled fibers 期刊论文
SCIENCE, 2019, 366 (6462) : 216-+
作者:  Wang, Run;  Fang, Shaoli;  Xiao, Yicheng;  Gao, Enlai;  Jiang, Nan;  Li, Yaowang;  Mou, Linlin;  Shen, Yanan;  Zhao, Wubin;  Li, Sitong;  Fonseca, Alexandre F.;  Galvao, Douglas S.;  Chen, Mengmeng;  He, Wenqian;  Yu, Kaiqing;  Lu, Hongbing;  Wang, Xuemin;  Qian, Dong;  Aliev, Ali E.;  Li, Na;  Haines, Carter S.;  Liu, Zhongsheng;  Mu, Jiuke;  Wang, Zhong;  Yin, Shougen;  Lima, Marcio D.;  An, Baigang;  Zhou, Xiang;  Liu, Zunfeng;  Baughman, Ray H.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Wang, Yidong;  Wu, Bingruo;  Lu, Pengfei;  Zhang, Donghong;  Wu, Brian;  Varshney, Shweta;  del Monte-Nieto, Gonzalo;  Zhuang, Zhenwu;  Charafeddine, Rabab;  Kramer, Adam H.;  Sibinga, Nicolas E.;  Frangogiannis, Nikolaos G.;  Kitsis, Richard N.;  Adams, Ralf H.;  Alitalo, Kari;  Sharp, David J.;  Harvey, Richard P.;  Stanley, Pamela;  Zhou, Bin
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Kamiya, Y.;  Ge, L.;  Hong, Tao;  Qiu, Y.;  Quintero-Castro, D. L.;  Lu, Z.;  Cao, H. B.;  Matsuda, M.;  Choi, E. S.;  Batista, C. D.;  Mourigal, M.;  Zhou, N. D.;  Ma, J.
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
The human imperative of stabilizing global climate change at 1.5 degrees C 期刊论文
SCIENCE, 2019, 365 (6459) : 1263-+
作者:  Hoegh-Guldberg, O.;  Jacob, D.;  Taylor, M.;  Bolanos, T. Guillen;  Bindi, M.;  Brown, S.;  Camilloni, I. A.;  Diedhiou, A.;  Djalante, R.;  Ebi, K.;  Engelbrecht, F.;  Guiot, J.;  Hijioka, Y.;  Mehrotra, S.;  Hope, C. W.;  Payne, A. J.;  Poertner, H. -O.;  Seneviratne, S. I.;  Thomas, A.;  Warren, R.;  Zhou, G.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Shortened temperature-relevant period of spring leaf-out in temperate-zone trees 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Fu, Yongshuo H.;  Geng, Xiaojun;  Hao, Fanghua;  Vitasse, Yann;  Zohner, Constantin M.;  Zhang, Xuan;  Zhou, Xuancheng;  Yin, Guodong;  Penuelas, Josep;  Piao, Shilong;  Janssens, Ivan A.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
climatic warming  deciduous trees  leaf-out date  phenology  temperature-relevant period  
Giant thermal Hall conductivity in the pseudogap phase of cuprate superconductors 期刊论文
NATURE, 2019, 571 (7765) : 376-+
作者:  Grissonnanche, G.;  Legros, A.;  Badoux, S.;  Lefrancois, E.;  Zatko, V.;  Lizaire, M.;  Laliberte, F.;  Gourgout, A.;  Zhou, J. -S.;  Pyon, S.;  Takayama, T.;  Takagi, H.;  Ono, S.;  Doiron-Leyraud, N.;  Taillefer, L.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Gyrl-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Yuan, Hua;  Zhang, Jinru;  Cai, Yujuan;  Wu, Sheng;  Yang, Kui;  Chan, H. C. Stephen;  Huang, Wei;  Jin, Wen-Bing;  Li, Yan;  Yin, Yue;  Igarashi, Yasuhiro;  Yuan, Shuguang;  Zhou, Jiahai;  Tang, Gong-Li
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
LNK suppresses interferon signaling in melanoma 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ding, Ling-Wen;  Sun, Qiao-Yang;  Edwards, Jarem J.;  Fernandez, Lucia Torres;  Ran, Xue-Bin;  Zhou, Si-Qin;  Scolyer, Richard A.;  Wilmott, James S.;  Thompson, John F.;  Ngan Doan;  Said, Jonathan W.;  Venkatachalam, Nachiyappan;  Xiao, Jin-Fen;  Loh, Xin-Yi;  Pein, Maren;  Xu, Liang;  Mullins, David W.;  Yang, Henry;  Lin, De-Chen;  Koeffler, H. Phillip
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Short photoperiod reduces the temperature sensitivity of leaf-out in saplings of Fagus sylvatica but not in horse chestnut 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (5) : 1696-1703
作者:  Fu, Yongshuo H.;  Piao, Shilong;  Zhou, Xuancheng;  Geng, Xiaojun;  Hao, Fanghua;  Vitasse, Yann;  Janssens, Ivan A.
收藏  |  浏览/下载：23/0  |  提交时间：2019/11/26
climate warming  photoperiod  spring phenology  temperature sensitivity  temperature threshold