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Raindrop size distribution and microphysical characteristics of a great rainstorm in 2016 in Beijing, China 期刊论文
ATMOSPHERIC RESEARCH, 2020, 239
作者:  Luo, Li;  Xiao, Hui;  Yang, Huiling;  Chen, Haonan;  Guo, Jia;  Sun, Yue;  Feng, Liang
收藏  |  浏览/下载：12/0  |  提交时间：2020/08/18
Great rainstorm  Northern China  Raindrop size distribution  Precipitation microphysics  Z-R relation  
Multiple transpolar auroral arcs reveal insight about coupling processes in the Earth's magnetotail 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (28) : 16193-16198
作者:  Zhang, Qing-He;  Zhang, Yong-Liang;  Wang, Chi;  Lockwood, Michael;  Yang, Hui-Gen;  Tang, Bin-Bin;  Xing, Zan-Yang;  Oksavik, Kjellmar;  Lyons, Larry R.;  Ma, Yu-Zhang;  Zong, Qiu-Gang;  Moen, Joran Idar;  Xia, Li-Dong
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/06
aurora  solar-terrestrial interaction  magnetosphere  polar ionosphere  transpolar auroral arcs  
Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
Marine organic matter in the remote environment of the Cape Verde islands - an introduction and overview to the MarParCloud campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 6921-6951
作者:  van Pinxteren, Manuela;  Fomba, Khanneh Wadinga;  Triesch, Nadja;  Stolle, Christian;  Wurl, Oliver;  Bahlmann, Enno;  Gong, Xianda;  Voigtlaender, Jens;  Wex, Heike;  Robinson, Tiera-Brandy;  Barthel, Stefan;  Zeppenfeld, Sebastian;  Hoffmann, Erik Hans;  Roveretto, Marie;  Li, Chunlin;  Grosselin, Benoit;  Daele, Veronique;  Senf, Fabian;  van Pinxteren, Dominik;  Manzi, Malena;  Zabalegui, Nicolas;  Frka, Sanja;  Gasparovic, Blazenka;  Pereira, Ryan;  Li, Tao;  Wen, Liang;  Li, Jiarong;  Zhu, Chao;  Chen, Hui;  Chen, Jianmin;  Fiedler, Bjoern;  Von Tuempling, Wolf;  Read, Katie Alana;  Punjabi, Shalini;  Lewis, Alastair Charles;  Hopkins, James Roland;  Carpenter, Lucy Jane;  Peeken, Ilka;  Rixen, Tim;  Schulz-Bull, Detlef;  Monge, Maria Eugenia;  Mellouki, Abdelwahid;  George, Christian;  Stratmann, Frank;  Herrmann, Hartmut
收藏  |  浏览/下载：23/0  |  提交时间：2020/08/18
Association between ambient temperature and hypertensive disorders in pregnancy in China 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Xiong, Tao;  Chen, Peiran;  Mu, Yi;  Li, Xiaohong;  Di, Baofeng;  Li, Jierui;  Qu, Yi;  Tang, Jun;  Liang, Juan;  Mu, Dezhi
收藏  |  浏览/下载：8/0  |  提交时间：2020/06/16
Controls on surface water carbonate chemistry along North American ocean margins 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Cai, Wei-Jun;  Xu, Yuan-Yuan;  Feely, Richard A.;  Wanninkhof, Rik;  Jonsson, Bror;  Alin, Simone R.;  Barbero, Leticia;  Cross, Jessica N.;  Azetsu-Scott, Kumiko;  Fassbender, Andrea J.;  Carter, Brendan R.;  Jiang, Li-Qing;  Pepin, Pierre;  Chen, Baoshan;  Hussain, Najid;  Reimer, Janet J.;  Xue, Liang;  Salisbury, Joseph E.;  Martin Hernandez-Ayon, Jose;  Langdon, Chris;  Li, Qian;  Sutton, Adrienne J.;  Chen, Chen-Tung A.;  Gledhill, Dwight K.
收藏  |  浏览/下载：14/0  |  提交时间：2020/06/09
Exploring the inconsistent variations in atmospheric primary and secondary pollutants during the 2016 G20 summit in Hangzhou, China: implications from observations and models 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5391-5403
作者:  Zhang, Gen;  Xu, Honghui;  Wang, Hongli;  Xue, Likun;  He, Jianjun;  Xu, Wanyun;  Qi, Bing;  Du, Rongguang;  Liu, Chang;  Li, Zeyuan;  Gui, Ke;  Jiang, Wanting;  Liang, Linlin;  Yan, Yan;  Meng, Xiaoyan
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/13
Exploring wintertime regional haze in northeast China: role of coal and biomass burning 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5355-5372
作者:  Zhang, Jian;  Liu, Lei;  Xu, Liang;  Lin, Qiuhan;  Zhao, Hujia;  Wang, Zhibin;  Guo, Song;  Hu, Min;  Liu, Dantong;  Shi, Zongbo;  Huang, Dao;  Li, Weijun
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/13
Aircraft observed diurnal variations of the planetary boundary layer under heat waves 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Zhang, Yuanjie;  Wang, Liang;  Santanello, Joseph A.;  Pan, Zaitao;  Gao, Zhiqiu;  Li, Dan
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/02
Planetary boundary layer  Heat wave  AMDAR  WVSS  Atmospheric circulation  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.