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Chesapeake Bay acidification buffered by spatially decoupled carbonate mineral cycling 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 441-+
作者:  Su, Jianzhong;  Cai, Wei-Jun;  Brodeur, Jean;  Chen, Baoshan;  Hussain, Najid;  Yao, Yichen;  Ni, Chaoying;  Testa, Jeremy M.;  Li, Ming;  Xie, Xiaohui;  Ni, Wenfei;  Scaboo, K. Michael;  Xu, Yuan-yuan;  Cornwell, Jeffrey;  Gurbisz, Cassie;  Owens, Michael S.;  Waldbusser, George G.;  Dai, Minhan;  Kemp, W. Michael
收藏  |  浏览/下载：13/0  |  提交时间：2020/06/09
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Rapid transfer of oxygen to the deep ocean mediated by bubbles 期刊论文
NATURE GEOSCIENCE, 2020, 13 (3) : 232-+
作者:  Atamanchuk, D.;  Koelling, J.;  Send, U.;  Wallace, D. W. R.
收藏  |  浏览/下载：2/0  |  提交时间：2020/05/13
Decadal variability in twentieth-century ocean acidification in the California Current Ecosystem 期刊论文
NATURE GEOSCIENCE, 2020, 13 (1) : 43-+
作者:  Osborne, Emily B.;  Thunell, Robert C.;  Gruber, Nicolas;  Feely, Richard A.;  Benitez-Nelson, Claudia R.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography 期刊论文
SCIENCE, 2019, 365 (6448) : 61-+
作者:  Weinert, Tobias;  Skopintsev, Petr;  James, Daniel;  Dworkowski, Florian;  Panepucci, Ezequiel;  Kekilli, Demet;  Furrer, Antonia;  Brunle, Steffen;  Mous, Sandra;  Ozerov, Dmitry;  Nogly, Przemyslaw;  Wang, Meitian;  Standfuss, Jorg
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
Drought impacts on terrestrial primary production underestimated by satellite monitoring 期刊论文
NATURE GEOSCIENCE, 2019, 12 (4) : 264-+
作者:  Stocker, Benjamin D.;  Zscheischler, Jakob;  Keenan, Trevor F.;  Prentice, I. Colin;  Seneviratne, Sonia I.;  Penuelas, Josep
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
An ingestible self-orienting system for oral delivery of macromolecules 期刊论文
SCIENCE, 2019, 363 (6427) : 611-+
作者:  Abramson, Alex;  Caffarel-Salvador, Ester;  Khang, Minsoo;  Dellal, David;  Silverstein, David;  Gao, Yuan;  Frederiksen, Morten Revsgaard;  Vegge, Andreas;  Hubalek, Frantisek;  Water, Jorrit J.;  Friderichsen, Anders V.;  Fels, Johannes;  Kirk, Rikke Kaae;  Cleveland, Cody;  Collins, Joy;  Tamang, Siddartha;  Hayward, Alison;  Landh, Tomas;  Buckley, Stephen T.;  Roxhed, Niclas;  Rahbek, Ulrik;  Langer, Robert;  Traverso, Giovanni
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Earth's radiative imbalance from the Last Glacial Maximum to the present 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (30) : 14881-14886
作者:  Baggenstos, Daniel;  Haberli, Marcel;  Schmitt, Jochen;  Shackleton, Sarah A.;  Birner, Benjamin;  Severinghaus, Jeffrey P.;  Kellerhals, Thomas;  Fischer, Hubertus
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
paleoclimate  deglaciation  noble gases  energy budget  ice cores  
Variable impacts of contemporary versus legacy agricultural phosphorus on US river water quality 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (41) : 20562-20567
作者:  Stackpoole, Sarah M.;  Stets, Edward G.;  Sprague, Lori A.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
legacy phosphorus  mass balance  eutrophication  phosphorus runoff  water-quality trend  
Current CaCO3 dissolution at the seafloor caused by anthropogenic CO2 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (46) : 11700-11705
作者:  Sulpis, Olivier;  Boudreau, Bernard P.;  Mucci, Alfonso;  Jenkins, Chris;  Trossman, David S.;  Arbic, Brian K.;  Key, Robert M.
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
ocean acidification  seafloor  CaCO3  dissolution  anthropogenic CO2