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DOI | 10.1126/science.aau2277 |
An ingestible self-orienting system for oral delivery of macromolecules | |
Abramson, Alex1,2; Caffarel-Salvador, Ester1,2,3; Khang, Minsoo1,2; Dellal, David3; Silverstein, David1,2; Gao, Yuan1,2; Frederiksen, Morten Revsgaard4; Vegge, Andreas4; Hubalek, Frantisek4; Water, Jorrit J.4; Friderichsen, Anders V.4; Fels, Johannes4; Kirk, Rikke Kaae4; Cleveland, Cody1,2,4; Collins, Joy1,2; Tamang, Siddartha1,2; Hayward, Alison1,2,5; Landh, Tomas4; Buckley, Stephen T.4; Roxhed, Niclas1,2,6; Rahbek, Ulrik4; Langer, Robert1,2,3,7; Traverso, Giovanni1,2,8,9 | |
2019-02-08 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6427页码:611-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Sweden |
英文摘要 | Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise's ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator's safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000458114200044 |
WOS关键词 | DRUG-DELIVERY ; INSULIN ; COMPLICATIONS ; MICRONEEDLES ; STOMACH ; TABLETS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200720 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, Dept Chem Engn, Cambridge, MA 02139 USA; 2.MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA; 3.MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 4.Novo Nordisk AS, Global Res Technol, Global Drug Discovery & Device R&D, Copenhagen, Denmark; 5.MIT, Div Comparat Med, Cambridge, MA 02139 USA; 6.KTH Royal Inst Technol, Dept Micro & Nanosyst, Stockholm, Sweden; 7.MIT, Media Lab, Cambridge, MA 02139 USA; 8.MIT, Dept Mech Engn, Cambridge, MA 02139 USA; 9.Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Abramson, Alex,Caffarel-Salvador, Ester,Khang, Minsoo,et al. An ingestible self-orienting system for oral delivery of macromolecules[J]. SCIENCE,2019,363(6427):611-+. |
APA | Abramson, Alex.,Caffarel-Salvador, Ester.,Khang, Minsoo.,Dellal, David.,Silverstein, David.,...&Traverso, Giovanni.(2019).An ingestible self-orienting system for oral delivery of macromolecules.SCIENCE,363(6427),611-+. |
MLA | Abramson, Alex,et al."An ingestible self-orienting system for oral delivery of macromolecules".SCIENCE 363.6427(2019):611-+. |
条目包含的文件 | 条目无相关文件。 |
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