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First published peer reviews of the WHO solidarity trials 新闻
来源平台：EurekAlert. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：0/0  |  提交时间：2020/11/20
Keep the data coming 新闻
来源平台：EurekAlert. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：2/0  |  提交时间：2020/11/20
New high-speed test shows how antibiotics combine to kill bacteria 新闻
来源平台：EurekAlert. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：4/0  |  提交时间：2020/09/22
Antagonistic cooperativity between crystal growth modifiers 期刊论文
NATURE, 2020, 577 (7791) : 497-+
作者:  Ma, Wenchuan;  Lutsko, James F.;  Rimer, Jeffrey D.;  Vekilov, Peter G.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/03

Inhibitor pairs that suppress the crystallization of haematin, which is a part of malaria parasites'  physiology, show unexpected antagonism due to attenuation of step pinning by kink blockers.


Ubiquitous processes in nature and the industry exploit crystallization from multicomponent environments(1-5)  however, laboratory efforts have focused on the crystallization of pure solutes(6,7) and the effects of single growth modifiers(8,9). Here we examine the molecular mechanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11). We use a combination of scanning probe microscopy and molecular modelling to demonstrate that inhibitor pairs, whose constituents adopt distinct mechanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor combination and applied concentrations. Synergism between two crystal growth modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not reflected in current crystal growth models. We demonstrate that kink blockers reduce the line tension of step edges, which facilitates both the nucleation of crystal layers and step propagation through the gates created by step pinners. The molecular viewpoint on cooperativity between crystallization modifiers provides guidance on the pairing of modifiers in the synthesis of crystalline materials. The proposed mechanisms indicate strategies to understand and control crystallization in both natural and engineered systems, which occurs in complex multicomponent media(1-3,8,9). In a broader context, our results highlight the complexity of crystal-modifier interactions mediated by the structure and dynamics of the crystal interface.


  
Repeated megaturbidite deposition in Lake Crescent, Washington, USA, triggered by Holocene ruptures of the Lake Creek-Boundary Creek fault system 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2019, 131: 2039-2055
作者:  Leithold, Elana L.;  Wegmann, Karl W.;  Bohnenstiehl, D. R.;  Joyner, Catelyn N.;  Pollen, Audrianna F.
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
Scientists warn about the dangerous interaction of plant protection products 新闻
来源平台：Science X network. 发布日期：2019
作者:  admin
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/16
Tropicalization process of the 7 November 2014 Mediterranean cyclone: Numerical sensitivity study 期刊论文
ATMOSPHERIC RESEARCH, 2017, 197
作者:  Carrio, D. S.;  Homar, V.;  Jansa, A.;  Romero, R.;  Picornell, M. A.
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Medicane  Extra-tropical cyclone  Cyclogenesis  Factor separation  Potential-vorticity inversion  Hart'  s diagram  
Genetic Factors Affecting Susceptibility to Low Dose & Low Dose-Rate Radiation 科技报告
来源：US Department of Energy (DOE). 出版年： 2014
作者:  Bedford, Joel
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/05
Genetic Factors Affecting Susceptibility to Low Dose & Low Dose-Rate Radiation