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Geochemical transition zone powering microbial growth in subsurface sediments 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Rui Zhao;  José M. Mogollón;  Sophie S. Abby;  Christa Schleper;  Jennifer F. Biddle;  Desiree L. Roerdink;  Ingunn H. Thorseth;  Steffen L. Jørgensen
收藏  |  浏览/下载:9/0  |  提交时间:2020/12/22
Evaluation of the Bulk Mass Flux Formulation Using Large-Eddy Simulations 期刊论文
Journal of the Atmospheric Sciences, 2020
作者:  Jian-Feng Gu;  Robert Stephen Plant;  Christopher E. Holloway;  Todd R. Jones;  Alison Stirling;  Peter A. Clark;  Steven J. Woolnough;  Thomas L. Webb
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/01
The proteome landscape of the kingdoms of life 期刊论文
NATURE, 2020
作者:  Arzi, Anat;  Rozenkrantz, Liron;  Gorodisky, Lior;  Rozenkrantz, Danit;  Holtzman, Yael;  Ravia, Aharon;  Bekinschtein, Tristan A.;  Galperin, Tatyana;  Krimchansky, Ben-Zion;  Cohen, Gal;  Oksamitni, Anna;  Aidinoff, Elena;  Sacher, Yaron;  Sobel, Noam
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind the study of genomes. Since the first essentially complete eukaryotic proteome was reported(1), advances in mass-spectrometry-based proteomics(2)have enabled increasingly comprehensive identification and quantification of the human proteome(3-6). However, there have been few comparisons across species(7,8), in stark contrast with genomics initiatives(9). Here we use an advanced proteomics workflow-in which the peptide separation step is performed by a microstructured and extremely reproducible chromatographic system-for the in-depth study of 100 taxonomically diverse organisms. With two million peptide and 340,000 stringent protein identifications obtained in a standardized manner, we double the number of proteins with solid experimental evidence known to the scientific community. The data also provide a large-scale case study for sequence-based machine learning, as we demonstrate by experimentally confirming the predicted properties of peptides fromBacteroides uniformis. Our results offer a comparative view of the functional organization of organisms across the entire evolutionary range. A remarkably high fraction of the total proteome mass in all kingdoms is dedicated to protein homeostasis and folding, highlighting the biological challenge of maintaining protein structure in all branches of life. Likewise, a universally high fraction is involved in supplying energy resources, although these pathways range from photosynthesis through iron sulfur metabolism to carbohydrate metabolism. Generally, however, proteins and proteomes are remarkably diverse between organisms, and they can readily be explored and functionally compared at www.proteomesoflife.org.


  
Mass-spectrometry-based draft of the Arabidopsis proteome 期刊论文
NATURE, 2020
作者:  Vasanthakumar, Ajithkumar;  Chisanga, David;  Blume, Jonas;  Gloury, Renee;  Britt, Kara;  Henstridge, Darren C.;  Zhan, Yifan;  Torres, Santiago Valle;  Liene, Sebastian;  Collins, Nicholas;  Cao, Enyuan;  Sidwell, Tom;  Li, Chaoran;  Spallanzani, Raul German;  Liao, Yang;  Beavis, Paul A.;  Gebhardt, Thomas;  Trevaskis, Natalie;  Nutt, Stephen L.;  Zajac, Jeffrey D.;  Davey, Rachel A.;  Febbraio, Mark A.;  Mathis, Diane;  Shi, Wei;  Kallies, Axel
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Plants are essential for life and are extremely diverse organisms with unique molecular capabilities(1). Here we present a quantitative atlas of the transcriptomes, proteomes and phosphoproteomes of 30 tissues of the model plant Arabidopsis thaliana. Our analysis provides initial answers to how many genes exist as proteins (more than 18,000), where they are expressed, in which approximate quantities (a dynamic range of more than six orders of magnitude) and to what extent they are phosphorylated (over 43,000 sites). We present examples of how the data may be used, such as to discover proteins that are translated from short open-reading frames, to uncover sequence motifs that are involved in the regulation of protein production, and to identify tissue-specific protein complexes or phosphorylation-mediated signalling events. Interactive access to this resource for the plant community is provided by the ProteomicsDB and ATHENA databases, which include powerful bioinformatics tools to explore and characterize Arabidopsis proteins, their modifications and interactions.


A quantitative atlas of the transcriptomes, proteomes and phosphoproteomes of 30 tissues of the model plant Arabidopsis thaliana provides a valuable resource for plant research.


  
PATENT LAW Draft bill reignites US debate over patenting human genes 期刊论文
SCIENCE, 2019, 364 (6445) : 1017-1017
作者:  Servick, Kelly
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
The opium poppy genome and morphinan production 期刊论文
SCIENCE, 2018, 362 (6412) : 343-+
作者:  Guo, Li;  Winzer, Thilo;  Yang, Xiaofei;  Li, Yi;  Ning, Zemin;  He, Zhesi;  Teodor, Roxana;  Lu, Ying;  Bowser, Tim A.;  Graham, Ian A.;  Ye, Kai
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Shifting the limits in wheat research and breeding using a fully annotated reference genome 期刊论文
SCIENCE, 2018, 361 (6403) : 661-+
作者:  Appels, Rudi;  39;Daiye, Amidou
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Primary Modes of Global Drop Size Distributions 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2018, 75 (5) : 1453-1476
作者:  Dolan, B.;  Fuchs, B.;  Rutledge, S. A.;  Barnes, E. A.;  Thompson, E. J.
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
Nepal Ambient Monitoring and Source Testing Experiment (NAMaSTE): emissions of particulate matter from wood- and dung-fueled cooking fires, garbage and crop residue burning, brick kilns, and other sources 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (3) : 2259-2286
作者:  Jayarathne, Thilina;  Stockwell, Chelsea E.;  Bhave, Prakash V.;  Praveen, Puppala S.;  Rathnayake, Chathurika M.;  Islam, Md. Robiul;  Panday, Arnico K.;  Adhikari, Sagar;  Maharjan, Rashmi;  Goetz, J. Douglas;  DeCarlo, Peter F.;  Saikawa, Eri;  Yokelson, Robert J.;  Stone, Elizabeth A.
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
Livestock drove ancient Old World inequality New World societies without draft animals had smaller gaps between haves and have-nots 期刊论文
SCIENCE, 2017, 358 (6365) : 850-850
作者:  Wade, Lizzie
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27